Non-Squamous Non-Small Cell Lung CancerPhase 3NCT01351415
A Study of Bevacizumab in Combination With Standard of Care Treatment in Participants With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC)
A Phase 3 study testing Bevacizumab, Docetaxel and Erlotinib in people with Non-Squamous Non-Small Cell Lung Cancer, run by Hoffmann-La Roche at 179 sites in 18 countries.
Trial summary
This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Non-Squamous Non-Small Cell Lung Cancer
- What is being tested?
- Bevacizumab, Docetaxel and Erlotinib
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 485 participants
- Where
- 179 sitesin 18 countries
- Study dates
- 25 Jun 2011to 25 Jun 2016
- Phase
- Phase 3
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Histologically or cytologically confirmed non-squamous NSCLC
- Documented progression of disease (locally recurrent or metastatic) per investigator assessment following first-line treatment with 4-6 cycles of Bevacizumab plus a platinum doublet-containing chemotherapy regimen and a minimum of 2 cycles of Bevacizumab (monotherapy) maintenance treatment prior to first progression of disease
- No treatment interruption of Bevacizumab treatment greater than 2 consecutive cycles (42 days) between the start of first-line treatment to start of Cycle 1 of second line treatment
- Randomization within 4 weeks of progression of disease
- At least one unidimensionally measurable lesion meeting RECIST v1.1 criteria
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- Participants with adequate hematological, liver, and renal function
- Female participants must not be pregnant or breast-feeding. Female participants of childbearing potential and fertile male participants must agree to use a highly effective contraceptive during the trial and for a period of at least 6 months following the last administration of trial drug(s)
Who cannot join
- Mixed, non-small cell and small cell tumors or mixed adenosquamous carcinomas with a predominant squamous component
- Epidermal growth factor receptor (EGFR)-mutation-positive disease according to local laboratory testing
- History of hemoptysis greater than or equal to (>/=) grade 2 within 3 months of randomization
- History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding and active gastrointestinal bleeding
- Major cardiac disease
- Treatment with any other investigational agent within 28 days prior to randomization
- Known hypersensitivity to bevacizumab or any of its excipients, or any SOC drugs foreseen
- Malignancy other than NSCLC within 5 years prior to randomization and evidence of any other disease that contraindicates the use of an investigational or SOC drug
Trial locations and contacts
179 sites in 18 countries.
179 sites in 18 countries
United States68 sites
McFarland Clinic
Ames, Iowa, 50010
Ann Arbor Hematology Oncology
Ann Arbor, Michigan, 48106
Anne Arundel Health System Research Instit-Annapolis Oncology Ctr
Annapolis, Maryland, 21401
Fox Valley Hema and Onc SC
Appleton, Wisconsin, 54915
Emory Univ Winship Cancer Inst
Atlanta, Georgia, 30322
Hematology/Oncology Clinic, LLP
Baton Rouge, Louisiana, 70809
St. Lukes Hospital and Health Network
Bethlehem, Pennsylvania, 18015
Lynn Cancer Institute - West
Boca Raton, Florida, 33428
Tufts Medical Center; Neely Cancer Center
Boston, Massachusetts, 02111
East Valley Hematology ; Oncology Medical Group
Burbank, California, 91505
Aultman Hospital
Canton, Ohio, 44710
Mid Ohio Onc Hematology Inc
Columbus, Ohio, 43219
Bay Area Hospital
Coos Bay, Oregon, 97420
Unv of TX SW Med Cntr; Hematology/Onc
Dallas, Texas, 75390-9015
Dayton Clinical Oncology Prog
Dayton, Ohio, 45420
Henry Ford Hospital; Hematology Oncology
Detroit, Michigan, 48202
Hematology & Oncology Assoc; North Eastern Pennsylvania
Dunmore, Pennsylvania, 18512
Alexian Brothers Neurosci Inst
Elk Grove Village, Illinois, 60007
California Cancer Associates for Research & Excellence, Inc.
Encinitas, California, 92008
Oncology-Evanston Nthwest Healthcare Kellogg Cancer Care Ctr
Evanston, Illinois, 60201
West Clinic
Germantown, Tennessee, 38138
Palo Verde Hema/Onc
Glendale, Arizona, 85304
Arizona Center for Cancer Care
Glendale, Arizona, 85306
Cancer & Hematology Center of West Michigan
Grand Rapids, Michigan, 49546
Carolina Oncology Specialists, PA - Hickory
Hickory, North Carolina, 28602
St. Francis Medical Group
Indianapolis, Indiana, 46237
Baptist - MD Anderson Cancer Center
Jacksonville, Florida, 32207
Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)
Jacksonville, Florida, 32256
Joliet Oncology Hematology Associates, Ltd.
Joliet, Illinois, 60435
Clopton Clinic
Jonesboro, Arkansas, 72401
University of Tennessee Medical Center Cancer Institute
Knoxville, Tennessee, 37920
Gundersen Lutheran
La Crosse, Wisconsin, 54601
Scripps Clinic; Hematology & Oncology
La Jolla, California, 92037-1027
Louisiana Oncology Associates
Lafayette, Louisiana, 70508
St. Mary Medical Center
Langhorne, Pennsylvania, 19047
University of Kentucky Medical Center
Lexington, Kentucky, 40536
Jewish Cancer Care
Louisville, Kentucky, 40245
UNI OF WISCONSIN SCHOOL OF MEDICINE; GI Oncology Research Group, Paul P Carbone Cancer Center
Madison, Wisconsin, 53792
Mount Sinai Medical Center
Miami Beach, Florida, 33140
Signal Point Clinical; Research Center, LLC
Middletown, Ohio, 45042
USA Mitchell Cancer Institute
Mobile, Alabama, 36688
The Hospital of Central CT
New Britain, Connecticut, 06050
Oncology Hematology Associates of Southwest Indiana
Newburgh, Indiana, 47630
Cancer Care & Hematology; Specialists of Chicagoland
Niles, Illinois, 60714
Eastern Ct Hema/Onco Assoc; Dept of Oncology
Norwich, Connecticut, 06360
Memorial Hospital of Rhode Island
Pawtucket, Rhode Island, 02860
University of Pennsylvania; Radiation Oncology
Philadelphia, Pennsylvania, 19104
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
Temple University Hospital
Philadelphia, Pennsylvania, 19140
Delta Hematology/ Oncology Associates
Portsmouth, Virginia, 23704
Kootenai Cancer Center
Post Falls, Idaho, 83854
W. Suburban Ctr for Cncer Care
River Forest, Illinois, 60305
Blue Ridge Cancer Care - Roanoke
Roanoke, Virginia, 24014
Cancer Care Centers of Brevard
Rockledge, Florida, 32955
Sutter Cancer Center
Sacramento, California, 95816
St Joseph Oncology
Saint Joseph, Missouri, 64507
Metro-Minnesota CCOP
Saint Louis Park, Minnesota, 55416
Coastal Integrative Cancer Care
San Luis Obispo, California, 93401
Summit Cancer Care PC
Savannah, Georgia, 31405
New England Cancer Specialists
Scarborough, Maine, 04074
Medical Oncology Associates
Spokane, Washington, 99208
Heartland CCOP/Missouri Baptist Medical Center
St Louis, Missouri, 63131
Stony Brook Univ Cancer Ctr; Medical Oncology Clinic
Stony Brook, New York, 11794-9447
Toledo Hospital; CCOP Toledo
Toledo, Ohio, 43617
Innovative Clinical Research Institute
Whittier, California, 90603
Cancer Center of Kansas
Wichita, Kansas, 67214-3728
Lankenau Hospital
Wynnewood, Pennsylvania, 19096
York Hospital
York Village, Maine, 03909
France19 sites
Poly Parc Rambot La Provencale; Chimiotherapie Ambulatoire
Aix-en-Provence, 13617
Centre Francois Baclesse; Oncologie
Caen, 14076
Centre Hospitalier Intercommunal; Service de Pneumologie
Créteil, 94010
Hopital Nord Ouest;Unite 2c
Gleizé, 69400
Centre Oscar Lambret
Lille, 59020
Hopital Calmette; Pneumologie
Lille, 59037
Hopital Louis Pradel; Cardiologie B
Lyon, 69394
Hôpital Saint Joseph; Oncologie Medicale
Marseille, 13285
Hopital Nord; Service d'Oncologie Multidisciplinaire et Innovation Thérapeutique
Marseille, 13915
Centre Antoine Lacassagne
Nice, 06189
Ch Lyon Sud; Chir Onc Gyne Sct Jules Courmont
Pierre-Bénite, 69310
CH Rene Dubos; Oncologie
Pontoise, 95300
Ico Rene Gauducheau; Oncologie
Saint-Herblain, 44805
Institut de Cancérologie de Loire
Saint-Priest-en-Jarez, 42271
Centre Paul Strauss; Oncologie Medicale
Strasbourg, 67065
Hia Sainte Anne; Pneumologie
Toulon, 83041
Hopital Sainte Musse; Pneumologie
Toulon, 83056
Clinique Pasteur; Pneumologie
Toulouse, 31076
Chi De La Haute Saone De Vesoul; Pneumologie
Vesoul, 70014
Germany15 sites
Zentralklinik Bad Berka GmbH; Pneumologie
Bad Berka, 99437
Praxis Dr. med. David Borquez
Bergisch Gladbach, 51465
Klinikum Esslingen; Klinik für Kardiologie, Angiologie und Pneumologie
Esslingen am Neckar, 73730
Krankenhaus Nordwest; Klinik f. Onkologie und Hämatologie
Frankfurt, 60488
SRH Wald-Klinikum Gera; Klinik für Hautkrankheiten und Allergologie
Gera, 07548
LungenClinic Großhansdorf
Großhansdorf, 22927
Krankenhaus Martha-Maria Halle-Doelau gGmbH; Klinik fuer Innere Medizin I
Halle, 06120
Universitaetsklinikum des Saarlandes; Innere Medizin V
Homburg/Saar, 66421
Fachklinik für Lungenerkrankungen
Immenhausen, 34376
St. Vincentius Kliniken Karlsruhe; Abteilung Hämatologie / Onkologie
Karlsruhe, 76137
Robert-Koch-Klinik; Pneumologie
Leipzig, 04207
Praxis Christian Geßner
Leipzig, 04357
Johannes-Wesling-Klinikum Minden; Onkologische Ambulanz / Tagesklinik
Minden, 32429
Ludwig-Maximilians Uni Klinik Innenstadt; Medizinische Klinik
München, 80336
Pius-Hospital; Klinik fuer Haematologie und Onkologie
Oldenburg, 26121
Japan14 sites
Aichi Cancer Center Hospital; Respiratory Medicine
Aichi, 464-8681
National Cancer Center Hospital East; Thoracic Oncology
Chiba, 277-8577
National Hospital Organization Shikoku Cancer Center; Thoracic Oncology
Ehime, 791-0280
National Hospital Organization Kyushu Cancer Center, Thoracic Oncology
Fukuoka, 811-1395
Hyogo Cancer Center; Thoracic Oncology
Hyōgo, 673-8553
Kanagawa Cardiovascular and Respiratory Center; Respiratory Medicine
Kanagawa, 236-0051
Yokohama Municipal Citizen'S Hospital; Respiratory
Kanagawa, 240-8555
Miyagi Cancer Center; Respiratory Medicine
Miyagi, 981-1293
Okayama University Hospital; Respiratory and Allergy Medicine
Okayama, 700-8558
OSAKA CITY GENERAL HOSPITAL;Medical Oncology
Osaka, 534-0021
Osaka International Cancer Institute; Thoracic Oncology
Osaka, 541-8567
Shizuoka Cancer Center; Thoracic Oncology
Shizuoka, 411-8777
National Cancer Center Hospital; Thoracic Medical Oncology
Tokyo, 104-0045
The Cancer Institute Hospital of JFCR, Respiratory Medicine
Tokyo, 135-8550
Brazil10 sites
Sociedade beneficente de senhoras Hospital Sirio Libanes
Brasília, Federal District, 70200-730
Centro de Estudos e Pesquisas Oncologicas - CESPO
Brasília, Federal District, 70390-150
Centro de Pesquisa Clínica- Instituto do Câncer do Ceará- ICC
Fortaleza, Ceará, 60125-120
Hospital de Caridade de Ijui; Oncologia
Ijuí, Rio Grande do Sul, 98700-000
Clinica de Neoplasias Litoral
Itajaí, Santa Catarina, 88301-220
Clinicas Oncologicas Integradas - COI
Rio de Janeiro, Rio de Janeiro, 22793-080
Nucleo de Oncologia da Bahia - NOB
Salvador, Bahia, Estado de Bahia, 40170-380
Hospital A. C. Camargo; Oncologia
São Paulo, São Paulo, 01509-010
Hospital Sao Jose
São Paulo, São Paulo, CEP 01321-001
Instituto de Câncer de Brasília
Taguatinga, Federal District, 72110-980
Austria8 sites
LKH Hohenems; Abteilung für Pulmologie
Hohenems, 6845
Tiroler Landeskrankenanstalten Ges.M.B.H.; Innere Medizin Abt. Für Hämatologie & Onkologie
Innsbruck, 6020
Lkh Natters; Abt. Für Atemwegs- & Lungenkrankheiten
Natters, 6161
A.Ö. LKH; Abt. für Lungenkrankheiten
Steyr, 4400
Medizinische Universität Wien; Univ.Klinik für Innere Medizin I - Abt. für Onkologie
Vienna, 1090
Krankenhaus Der Stadt Wien Lainz; V. Medizinische Abt.
Vienna, 1130
SMZ - Baumgartner Hohe, Pavilion Leopold; 1.Interne Lungenabteilung, Onkologische Tagesklinik
Vienna, 1140
Klinikum Wels-Grieskirchen; Lungenabt.
Wels, 4600
Spain8 sites
Hospital General Univ. de Alicante; Servicio de Oncologia
Alicante, 3010
Hospital de Cruces; Servicio de Oncologia
Barakaldo, Vizcaya, 48903
Centro Oncologico MD Anderson International Espana
Madrid, 28033
Hospital Universitario Clínico San Carlos; Servicio de Oncologia
Madrid, 28040
Hospital Universitario La Paz; Servicio de Oncologia
Madrid, 28046
Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia
Valencia, 46010
Hospital Universitario Dr. Peset; Servicio de Oncologia
Valencia, 46017
Hospital Universitario Miguel Servet; Servicio Oncologia
Zaragoza, 50009
Italy7 sites
Citta Ospedaliera; Divisione Oncologia Medica
Avellino, Campania, 83100
IRCCS Istituto Nazionale Per La Ricerca Sul Cancro (IST); Oncologia Medica A
Genoa, Liguria, 16132
IRCCS Istituto Nazionale Tumori Fondazione Pascale; Oncologia Medica A
Naples, Campania, 80131
A.O. Universitaria Pisana-Ospedale Cisanello; Dipartimento Cardio Toracico-Pneumologia Ii
Pisa, Tuscany, 56124
Policlinico Universitario Campus Biomedico; Uoc Oncologia Medica
Rome, Lazio, 00128
Azienda Ospedaliera San Camillo Forlanini; U.O.C. Pneumologia Ad Indirizzo Oncologico 1
Rome, Lazio, 00152
Az. Osp. Di Busto P.O. Di Saronno; U.O. Di Oncologia Medica
Saronno, Lombardy, 21047
Argentina6 sites
Inst. Alexander Fleming; Oncology Dept
Buenos Aires, C1426ANZ
Centro Oncologico Infinito; Oncologia
La Pampa, 6300
Hospital Privado de Comunidad; Oncology
Mar del Plata, 7600
Sanatorio Parque de Rosario
Rosario, S2000DSV
ISIS Clinica Especializada
Santa Fe, 03000
Clínica Viedma
Viedma, Rio Negro, 8500
Netherlands6 sites
Amphia Ziekenhuis; Afdeling Longziekten
Breda, 4818 CK
Catharina Ziekenhuis; Dept of Lung Diseases
Eindhoven, 5623 EJ
Ziekenhuis St Jansdal; Dept of Lung Diseases
Harderwijk, 3844 DG
Academisch Ziekenhuis Maastricht
Maastricht, 6202 AZ
Antonius Ziekenhuis; Dept of Lung Diseases
Nieuwegein, 3435 CM
Leyenburg Hospital; Pulmonology
The Hague, 2504 LN
Greece4 sites
Sotiria Hospital
Athens, 11527
Metropolitan Hospital; 2Nd Oncology Clinic
Piraeus, 185 47
General Hospital of Thessaloniki Papanikolaou; Uni Pneumonology Dept.
Thessaloniki, 570 10
Diavalkaniko Hospital
Thessaloniki, 57001
Slovakia4 sites
Fnsp Fdr Banska Bystrica; Dep of Pneumology&Ftizeology
Banská Bystrica, 975 17
FNsP Bratislava, Nemocnica Ruzinov
Bratislava, 826 06
Vychodoslovensky onkologicky ustav
Košice, 04001
Inst. of Tb & Respiratory Diseases; Dep. of Oncology
Nitra, 949 88
Lebanon3 sites
American University of Beirut - Medical Center
Beirut, 11-236
Hotel Dieu de France; Oncology
Beirut, 16830
Middle East Inst. of Health; Oncology
Beirut
Mexico3 sites
Centenario Hospital Miguel Hidalgo
Aguascalientes, 20230
Hospital Central Sur de Alta Especialidad Petróleos Mexicanos
Mexico City, 14140
Centro Médico Abc the American British Cowdray Medical Center, I.A.P. - Centro de Cáncer
Mexico City
Denmark1 site
Nordsjællands Hospital, Hillerød, Onkologisk Afdeling
Hillerød, 3400
Oman1 site
College of Medicine & Sciences, Sultan Qaboos University Hospital
Muscat, P.O Box 35
United Arab Emirates1 site
Tawam Hospital; Medical Oncology Department
Al Ain City, 15258
About this study
Official title: An Open-label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease (PD) in Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC) After First Line Treatment With Bevacizumab Plus a Platinum Doublet-containing Chemotherapy
This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Participants will be enrolled at documentation of progression of disease (PD) after 4-6 cycles of first-line treatment with bevacizumab plus a platinum doublet-containing therapy and a minimum of two cycles of bevacizumab maintenance treatment prior to PD. Participants will be randomly assigned to one of two treatment arms to receive either bevacizumab plus SOC treatment or SOC treatment alone.
- Conditions
- Non-Squamous Non-Small Cell Lung Cancer
- Being tested
- Bevacizumab, Docetaxel, Erlotinib, Pemetrexed
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
BevacizumabDrug
Also called Avastin
Participants will receive bevacizumab 7.5 or 15 milligrams per kilogram (mg/kg) intravenously.
DocetaxelDrug
Docetaxel 60 or 75 milligram per meter square (mg/m^2) on Day 1 every 21 days.
ErlotinibDrug
Erlotinib 150 mg daily taken on an empty stomach at least one hour before or two hours after the ingestion of food.
PemetrexedDrug
Pemetrexed 500 mg/m^2 IV over 10 minutes on Day 1 every 21 days.
| Study group | Role | What they receive |
|---|---|---|
| Bevacizumab + Standard of Care | Experimental | Participants will receive bevacizumab on Day 1 of every 21-days cycle along with standard of care (Erlotinib or Docetaxel or Pemetrexed) as second line treatment, until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first). Receives: Drug: Bevacizumab; Drug: Docetaxel; Drug: Erlotinib; Drug: Pemetrexed |
| Standard of Care | Active comparator | Participants will receive investigator's choice of standard of care (Erlotinib or Docetaxel or Pemetrexed) according to local practice until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first). Receives: Drug: Docetaxel; Drug: Erlotinib; Drug: Pemetrexed |
What is being measured
The primary outcome is the main question the study is designed to answer.
Overall Survival (OS)
Overall survival (OS) was defined as the time from the date of randomization at first progression of disease to the date of death, regardless of the cause of death.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Secondary outcomes (7)
Progression-free Survival (PFS) According to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)
PFS was defined as the time from start of treatment to the first event of death or PD. Tumor response was assessed by the IRF according to RECIST v1.1. Disease progression or PD was defined as ≥20% increase in sum LD in reference to the smallest on-study sum LD, or the appearance of new lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. PFS2 is defined as the time between randomization at PD1 and the date of PD2 or death, whichever occurs first. PFS3 is defined as the time between PD2 and the date of PD3 or death, whichever occurs first.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Objective Response According to RECIST v1.1
The objective response is defined as complete response (CR) or partial response (PR) assessed according to the RECIST v.1.1 criteria with baseline tumour assessment as the reference. CR was defined as disappearance of all target and non-target lesions and (if applicable) normalization of tumor marker levels. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to <10 mm. PR was defined as greater than or equal to (≥) 30 percent (%) decrease in sum of longest diameter (LD) of target lesions in reference to Baseline sum LD. Response was to be confirmed ≥4 weeks after the initial assessment of CR or PR.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Disease Control According to RECIST v1.1
The disease control rate is defined as CR or PR or stable disease (SD) assessed according to the RECIST v.1.1 criteria with baseline tumour assessment as the reference. SD was defined as neither sufficient shrinkage to qualify for a PR nor sufficient increase to qualify for PD, taking as reference the smallest sum of the longest diameter since treatment started for target lesions and the persistence of 1 or more non-target lesions.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Duration of Response (DoR) According to RECIST v1.1
Duration of response is defined as the time that measurement criteria are met for objective response (CR/PR) (whichever status is recorded first) until the first date of progression or death is documented. CR was defined as disappearance of all target and non-target lesions and (if applicable) normalization of tumor marker levels. Any pathological lymph nodes (whether target or non-target) must have reduction in short axis to less than < 10 mm. PR was defined as greater than or equal to ≥30 % decrease in sum of longest diameter of target lesions in reference to baseline sum longest diameter.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)
An AE was considered any unfavorable and unintended sign, symptom, or disease associated with the use of the study drug, whether or not considered related to the study drug. Preexisting conditions that worsened during the study and laboratory or clinical tests that resulted in a change in treatment or discontinuation from study drug were reported as adverse events. A SAE was any experience that: resulted in death, was life-threatening, required in-patient hospitalization or prolongation of existing hospitalization, resulted in persistent or significant disability/incapacity, was a congenital anomaly/birth defect or was medically significant.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Time to Progression (TTP) According to RECIST v1.1
The time to progression was defined as the time from baseline until disease progression as determined by the RECIST v1.1. TTP2 is defined as the interval between the day of randomization at PD1 and PD2. TTP3 is defined as the interval between the day of PD2 and PD3. PD was defined as ≥20% increase in sum LD in reference to the smallest on-study sum LD, or the appearance of new lesions. In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm.
Measured: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants Who Are Alive at Month 6, 12, and 18
Percentage of participants who were alive at Month 6, 12 and 18 were reported.
Measured: Month 6, 12, 18
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 May 2011 (estimated)
- Study start25 Jun 2011
- Primary completion25 Jun 2016
- Study completion25 Jun 2016
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (3)Papers the sponsor has linked to this study.
- Other trials for Non-Squamous Non-Small Cell Lung CancerStudies of the same condition, open and under way.
- More trials run by Hoffmann-La RocheThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 3
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 485 participants (actual)
Sponsor and investigators
- Lead sponsor
- Hoffmann-La Roche
- Sponsor type
- Industry (pharma, biotech, devices)
- Responsible party
- Sponsor
- Investigators
- Clinical Trials, Study director, Hoffmann-La Roche
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01351415
- Sponsor's protocol ID
- MO22097
- Other IDs
- 2010-022645-14
- Status last verified
- Aug 2017
- First submitted
- 9 May 2011
- Last updated
- 18 Sep 2017
- Results posted
- Yes, on ClinicalTrials.gov
Publications
Gridelli C, de Castro Carpeno J, Dingemans AC, Griesinger F, Grossi F, Langer C, Ohe Y, Syrigos K, Thatcher N, Das-Gupta A, Truman M, Donica M, Smoljanovic V, Bennouna J. Safety and Efficacy of Bevacizumab Plus Standard-of-Care Treatment Beyond Disease Progression in Patients With Advanced Non-Small Cell Lung Cancer: The AvaALL Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):e183486. doi: 10.1001/jamaoncol.2018.3486. Epub 2018 Dec 13.
PubMed 30177994Takeda M, Yamanaka T, Seto T, Hayashi H, Azuma K, Okada M, Sugawara S, Daga H, Hirashima T, Yonesaka K, Urata Y, Murakami H, Saito H, Kubo A, Sawa T, Miyahara E, Nogami N, Nakagawa K, Nakanishi Y, Okamoto I. Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial. Cancer. 2016 Apr 1;122(7):1050-9. doi: 10.1002/cncr.29893. Epub 2016 Feb 1.
PubMed 26828788Gridelli C, Bennouna J, de Castro J, Dingemans AM, Griesinger F, Grossi F, Rossi A, Thatcher N, Wong EK, Langer C. Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rationale and protocol dynamics of the AvaALL (MO22097) trial. Clin Lung Cancer. 2011 Nov;12(6):407-11. doi: 10.1016/j.cllc.2011.05.002. Epub 2011 Jun 25.
PubMed 21705281
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- An Open-label, Randomized, Phase IIIb Trial Evaluating the Efficacy and Safety of Standard of Care +/- Continuous Bevacizumab Treatment Beyond Progression of Disease (PD) in Patients With Advanced Non-squamous Non-small Cell Lung Cancer (NSCLC) After First Line Treatment With Bevacizumab Plus a Platinum Doublet-containing Chemotherapy
- ClinicalTrials.gov ID
- NCT01351415
- Acronym / sponsor ID
- MO22097
- Conditions
- Non-Squamous Non-Small Cell Lung Cancer
- Phase
- Phase 3
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 485 participants (actual)
- Lead sponsor
- Hoffmann-La RocheIndustry (pharma, biotech, devices)
- Study start
- 25 Jun 2011 (actual)
- Primary completion
- 25 Jun 2016 (actual)
- Study completion
- 25 Jun 2016 (actual)
- First posted
- 10 May 2011 (estimated)
- Results
- Posted 18 Sep 2017
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This open-label, randomized, multicenter study will evaluate the efficacy and safety of bevacizumab (Avastin) in combination with standard of care (SOC) treatment in participants with advanced non-squamous NSCLC. Participants will be enrolled at documentation of progression of disease (PD) after 4-6 cycles of first-line treatment with bevacizumab plus a platinum doublet-containing therapy and a minimum of two cycles of bevacizumab maintenance treatment prior to PD. Participants will be randomly assigned to one of two treatment arms to receive either bevacizumab plus SOC treatment or SOC treatment alone.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Bevacizumab + Standard of Care | Experimental | Drug: Bevacizumab, Drug: Docetaxel, Drug: Erlotinib, Drug: PemetrexedParticipants will receive bevacizumab on Day 1 of every 21-days cycle along with standard of care (Erlotinib or Docetaxel or Pemetrexed) as second line treatment, until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first). |
| Standard of Care | Active comparator | Drug: Docetaxel, Drug: Erlotinib, Drug: PemetrexedParticipants will receive investigator's choice of standard of care (Erlotinib or Docetaxel or Pemetrexed) according to local practice until the occurrence of an unacceptable toxicity or withdrawal of consent (whichever occurs first). |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Histologically or cytologically confirmed non-squamous NSCLC
- Documented progression of disease (locally recurrent or metastatic) per investigator assessment following first-line treatment with 4-6 cycles of Bevacizumab plus a platinum doublet-containing chemotherapy regimen and a minimum of 2 cycles of Bevacizumab (monotherapy) maintenance treatment prior to first progression of disease
- No treatment interruption of Bevacizumab treatment greater than 2 consecutive cycles (42 days) between the start of first-line treatment to start of Cycle 1 of second line treatment
- Randomization within 4 weeks of progression of disease
- At least one unidimensionally measurable lesion meeting RECIST v1.1 criteria
Key exclusion criteria (8 listed)
- Mixed, non-small cell and small cell tumors or mixed adenosquamous carcinomas with a predominant squamous component
- Epidermal growth factor receptor (EGFR)-mutation-positive disease according to local laboratory testing
- History of hemoptysis greater than or equal to (>/=) grade 2 within 3 months of randomization
- History or evidence of inherited bleeding diathesis or coagulopathy with a risk of bleeding and active gastrointestinal bleeding
- Major cardiac disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| BevacizumabAlso: AvastinParticipants will receive bevacizumab 7.5 or 15 milligrams per kilogram (mg/kg) intravenously. | Drug | Bevacizumab + Standard of Care |
| DocetaxelDocetaxel 60 or 75 milligram per meter square (mg/m^2) on Day 1 every 21 days. | Drug | Bevacizumab + Standard of Care, Standard of Care |
| ErlotinibErlotinib 150 mg daily taken on an empty stomach at least one hour before or two hours after the ingestion of food. | Drug | Bevacizumab + Standard of Care, Standard of Care |
| PemetrexedPemetrexed 500 mg/m^2 IV over 10 minutes on Day 1 every 21 days. | Drug | Bevacizumab + Standard of Care, Standard of Care |
Primary outcome
Overall Survival (OS)
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Overall survival (OS) was defined as the time from the date of randomization at first progression of disease to the date of death, regardless of the cause of death.
7 secondary outcomes
Progression-free Survival (PFS) According to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Objective Response According to RECIST v1.1
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Disease Control According to RECIST v1.1
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Duration of Response (DoR) According to RECIST v1.1
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs)
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Time to Progression (TTP) According to RECIST v1.1
Time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)
Percentage of Participants Who Are Alive at Month 6, 12, and 18
Time frame: Month 6, 12, 18
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2017.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Derived from this study: PubMed 30177994Gridelli C, de Castro Carpeno J, Dingemans AC, Griesinger F, Grossi F, Langer C, Ohe Y, Syrigos K, Thatcher N, Das-Gupta A, Truman M, Donica M, Smoljanovic V, Bennouna J. Safety and Efficacy of Bevacizumab Plus Standard-of-Care Treatment Beyond Disease Progression in Patients With Advanced Non-Small Cell Lung Cancer: The AvaALL Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):e183486. doi: 10.1001/jamaoncol.2018.3486. Epub 2018 Dec 13.
- Derived from this study: PubMed 26828788Takeda M, Yamanaka T, Seto T, Hayashi H, Azuma K, Okada M, Sugawara S, Daga H, Hirashima T, Yonesaka K, Urata Y, Murakami H, Saito H, Kubo A, Sawa T, Miyahara E, Nogami N, Nakagawa K, Nakanishi Y, Okamoto I. Bevacizumab beyond disease progression after first-line treatment with bevacizumab plus chemotherapy in advanced nonsquamous non-small cell lung cancer (West Japan Oncology Group 5910L): An open-label, randomized, phase 2 trial. Cancer. 2016 Apr 1;122(7):1050-9. doi: 10.1002/cncr.29893. Epub 2016 Feb 1.
- Derived from this study: PubMed 21705281Gridelli C, Bennouna J, de Castro J, Dingemans AM, Griesinger F, Grossi F, Rossi A, Thatcher N, Wong EK, Langer C. Randomized phase IIIb trial evaluating the continuation of bevacizumab beyond disease progression in patients with advanced non-squamous non-small-cell lung cancer after first-line treatment with bevacizumab plus platinum-based chemotherapy: treatment rationale and protocol dynamics of the AvaALL (MO22097) trial. Clin Lung Cancer. 2011 Nov;12(6):407-11. doi: 10.1016/j.cllc.2011.05.002. Epub 2011 Jun 25.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Clinical Trials study director
Hoffmann-La Roche
179 sites in 18 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 3 study testing Bevacizumab, Docetaxel and Erlotinib in people with Non-Squamous Non-Small Cell Lung Cancer, run by Hoffmann-La Roche at 179 sites in 18 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Sep 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 179 sites in United States, France, Germany, Japan, Brazil and 13 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Yes. Results are posted in the registry (first posted 18 Sep 2017). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Overall Survival (OS) (time frame: Up to data cut-off date 24 June 2016 (approximately 5 years)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01351415, which also lists 3 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2017.