AzTrials
AzTrials

Hypertensionin-MAU-tionNCT01078584

Canadian Study of Trandolapril on Blood Pressure in Hypertensive Patients

An observational study of Hypertension, run by Abbott at 568 sites in Canada.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The in-MAU-tion study is conducted to determine the percentage of hypertensive participants with or without diabetes reaching CHEP (Canadian Hypertension Education Program) defined blood pressure targets. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Hypertension
How many people
7,993 participants
Where
568 sitesCanada
Study dates
Dec 2008to Sep 2011
Phase
Observational
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: Primary care clinics

Who may be able to join

  • Adults capable of providing consent and who have uncontrolled hypertension
  • Participants were either treatment-naïve or had uncontrolled hypertension on their existing antihypertensive medication.

Who cannot join

  • Participants were excluded from participation in the study if they had been taking trandolapril (Mavik®), alone or in combination, for more than 1 month prior to enrollment.

Trial locations and contacts

568 sites in 1 country.

300 sites in 1 country

Canada300 sites

  • Site Reference ID/Investigator# 37846

    100 Mile House, British Columbia, V0K 2E0

  • Site Reference ID/Investigator# 30893

    Abbotsford British Columbia, British Columbia, V2S 6R6

  • Site Reference ID/Investigator# 37728

    Abbotsford British Columbia, British Columbia, V2T 3S4

  • Site Reference ID/Investigator# 42367

    Ajax, Ontario, L1S 7K8

  • Site Reference ID/Investigator# 31375

    Aldergrove, British Columbia, V4W 3L6

  • Site Reference ID/Investigator# 31267

    Alma, Quebec, G8E 2K2

  • Site Reference ID/Investigator# 37942

    Alma, Quebec, G8E 2K2

  • Site Reference ID/Investigator# 42464

    Ameherstburg, Ontario, N9V 0B4

  • Site Reference ID/Investigator# 37885

    Amherstview, Ontario, K7N 1S3

  • Site Reference ID/Investigator# 30885

    Anjou, Quebec, H1M 3M4

  • Site Reference ID/Investigator# 42409

    Aurora, Ontario, L4G 7Y3

  • Site Reference ID/Investigator# 42449

    Aurora, Ontario, L4G 7Y3

  • Site Reference ID/Investigator# 30943

    Aurora, Ontario, L4G 7Z9

  • Site Reference ID/Investigator# 31331

    Aylmer, Quebec, N5H 1K9

  • Site Reference ID/Investigator# 30963

    Barrie, Ontario, L4N 6M2

  • Site Reference ID/Investigator# 31304

    Beauceville, Quebec, G5X 1J9

  • Site Reference ID/Investigator# 30954

    Belleville, Ontario, K8N 5G8

  • Site Reference ID/Investigator# 30879

    Belleville, Ontario, K8P 5E2

  • Site Reference ID/Investigator# 42378

    Bolton, Ontario, L7E 4C8

  • Site Reference ID/Investigator# 30888

    Bowmanville, Ontario, L1C 1P3

  • Site Reference ID/Investigator# 30947

    Bowmanville, Ontario, L1C 1P6

  • Site Reference ID/Investigator# 31286

    Bradford, Ontario, L3Z 2B6

  • Site Reference ID/Investigator# 32192

    Bradford, Ontario, L3Z 2B8

  • Site Reference ID/Investigator# 37911

    Brampton, Ontario, L6R 3J5

  • Site Reference ID/Investigator# 37932

    Brampton, Ontario, L6T 3R5

  • Site Reference ID/Investigator# 30882

    Brampton, Ontario, L6X 5E9

  • Site Reference ID/Investigator# 37929

    Brampton, Ontario, L7A 3E5

  • Site Reference ID/Investigator# 32227

    Brandon, Manitoba, R7A 0B9

  • Site Reference ID/Investigator# 37768

    Brantford, Ontario, N3T 5Z8

  • Site Reference ID/Investigator# 31314

    Bridgewater, Nova Scotia, B4V 2V6

  • Site Reference ID/Investigator# 31276

    Bridgewater, Nova Scotia, B4V 3N2

  • Site Reference ID/Investigator# 31369

    Bromont, Quebec, J2L 2C3

  • Site Reference ID/Investigator# 30903

    Brossard, Quebec, J4Z 3G9

  • Site Reference ID/Investigator# 37934

    Burlington, Ontario, L7L 0B7

  • Site Reference ID/Investigator# 32173

    Burlington, Ontario, L7M 4Y1

  • Site Reference ID/Investigator# 32210

    Burlington, Ontario, L7R 1E2

  • Site Reference ID/Investigator# 37919

    Burlington, Ontario, L7R 2H3

  • Site Reference ID/Investigator# 31359

    Burlington, Ontario, L7R 2H7

  • Site Reference ID/Investigator# 37923

    Burlington, Ontario, L7R 2H7

  • Site Reference ID/Investigator# 37845

    Burlington, Ontario, L7R 4H9

  • Site Reference ID/Investigator# 30870

    Burnaby, British Columbia, V5C 5R4

  • Site Reference ID/Investigator# 30964

    Burnaby, British Columbia, V5E 1E7

  • Site Reference ID/Investigator# 31261

    Burnaby, British Columbia, V5H 2A9

  • Site Reference ID/Investigator# 30946

    Burnaby, British Columbia, V5H 4J2

  • Site Reference ID/Investigator# 30927

    Burnaby, British Columbia, V5H 4M4

  • Site Reference ID/Investigator# 32207

    Calgary, Alberta, T1Y 6H6

  • Site Reference ID/Investigator# 10283

    Calgary, Alberta, T2E 2S9

  • Site Reference ID/Investigator# 32168

    Calgary, Alberta, T2J 3N8

  • Site Reference ID/Investigator# 32147

    Calgary, Alberta, T2M 0H5

  • Site Reference ID/Investigator# 42438

    Calgary, Alberta, T2V 0M3

  • Site Reference ID/Investigator# 32157

    Calgary, Alberta, T2V 1K2

  • Site Reference ID/Investigator# 37940

    Calgary, Alberta, T2X 1P1

  • Site Reference ID/Investigator# 32199

    Calgary, Alberta, T2X 3X7

  • Site Reference ID/Investigator# 32144

    Calgary, Alberta, T3C 3P1

  • Site Reference ID/Investigator# 32169

    Calgary, Alberta, T3E 5R7

  • Site Reference ID/Investigator# 32145

    Charlottetown, Prince Edward Island, C1A 1L2

  • Site Reference ID/Investigator# 32195

    Charlottetown, Prince Edward Island, C1A 2M5

  • Site Reference ID/Investigator# 32221

    Charlottetown, Prince Edward Island, C1A 6Y1

  • Site Reference ID/Investigator# 42335

    Chicoutimi, Quebec, G7H 1G8

  • Site Reference ID/Investigator# 31260

    Chicoutimi, Quebec, G7J 2V1

  • Site Reference ID/Investigator# 31398

    Clemont, Quebec, G4A 1G3

  • Site Reference ID/Investigator# 30911

    Clermont, Quebec, G4A 1G3

  • Site Reference ID/Investigator# 31323

    Clermont, Quebec, G4A 1G3

  • Site Reference ID/Investigator# 47571

    Collingwood, Ontario, L9Y 1W6

  • Site Reference ID/Investigator# 30878

    Conception Bay South, Newfoundland and Labrador, A1W 3A6

  • Site Reference ID/Investigator# 42433

    Coquitlam, British Columbia, V3B 6J6

  • Site Reference ID/Investigator# 32213

    Coquitlam, British Columbia, V3B 6S2

  • Site Reference ID/Investigator# 30956

    Cornwall, Ontario, K6H 4A2

  • Site Reference ID/Investigator# 37897

    Cornwall, Prince Edward Island, C0A 1H0

  • Site Reference ID/Investigator# 30969

    Corunna, Ontario, N0N 1G0

  • Site Reference ID/Investigator# 30928

    Cote-St-Luc, Quebec, H3W 1Z7

  • Site Reference ID/Investigator# 37782

    Craik, Saskatchewan, S0G 0V0

  • Site Reference ID/Investigator# 31264

    Dartmouth, Nova Scotia, B2W 3E5

  • Site Reference ID/Investigator# 31321

    Dartmouth, Nova Scotia, B2W 3E5

  • Site Reference ID/Investigator# 30961

    Dashwood, Ontario, N0M 1N0

  • Site Reference ID/Investigator# 32166

    Delta, British Columbia, V4C 6R2

  • Site Reference ID/Investigator# 31288

    Delta, British Columbia, V4C 6R4

  • Site Reference ID/Investigator# 42404

    Delta, British Columbia, V4C 6R4

  • Site Reference ID/Investigator# 37922

    Delta, British Columbia, V4E 2A6

  • Site Reference ID/Investigator# 30926

    Delta, British Columbia, V4K 2K5

  • Site Reference ID/Investigator# 32209

    Dieppe, New Brunswick, E1A 1N5

  • Site Reference ID/Investigator# 37850

    Dolbeau-Mistassini, Ontario, G8L 5J8

  • Site Reference ID/Investigator# 42386

    Dolbeau-Mistassini, Quebec, G8L 1H1

  • Site Reference ID/Investigator# 31281

    Dolbeau-Mistassini, Quebec, G8L 5J8

  • Site Reference ID/Investigator# 42389

    Durham, Ontario, N0G 1R0

  • Site Reference ID/Investigator# 42385

    East York, Ontario, M4B 2S7

  • Site Reference ID/Investigator# 42397

    East York, Ontario, M4C 5M1

  • Site Reference ID/Investigator# 42400

    East York, Ontario, M4C 5M1

  • Site Reference ID/Investigator# 42423

    East York, Ontario, M4C 5M1

  • Site Reference ID/Investigator# 30930

    East York, Ontario, M4C 5T2

  • Site Reference ID/Investigator# 31363

    East York, Ontario, M4K 3V9

  • Site Reference ID/Investigator# 42391

    Edmonton, Alberta, T5C 3H7

  • Site Reference ID/Investigator# 32146

    Edmonton, Alberta, T5K 0N8

  • Site Reference ID/Investigator# 32165

    Edmonton, Alberta, T5T 2K6

  • Site Reference ID/Investigator# 32197

    Edmonton, Alberta, T5T 2K6

  • Site Reference ID/Investigator# 32126

    Edmonton, Alberta, T5T 4J5

  • Site Reference ID/Investigator# 37892

    Edmonton, Alberta, T5T 5L4

  • Site Reference ID/Investigator# 32178

    Edmonton, Alberta, T5T 5Y1

  • Site Reference ID/Investigator# 42406

    Edmonton, Alberta, T5W 4W1

  • Site Reference ID/Investigator# 32160

    Edmonton, Alberta, T5X 3N5

  • Site Reference ID/Investigator# 32200

    Edmonton, Alberta, T5X 3N5

  • Site Reference ID/Investigator# 32149

    Edmonton, Alberta, T6A 0A5

  • Site Reference ID/Investigator# 32156

    Edmonton, Alberta, T6B 0P2

  • Site Reference ID/Investigator# 32216

    Edmonton, Alberta, T6H 5B4

  • Site Reference ID/Investigator# 32206

    Edmonton, Alberta, T6L 6N3

  • Site Reference ID/Investigator# 42342

    Elmvale, Ontario, L0L 1P0

  • Site Reference ID/Investigator# 32873

    Etobicoke, Ontario, M8V 3X8

  • Site Reference ID/Investigator# 31353

    Etobicoke, Ontario, M8W 3W2

  • Site Reference ID/Investigator# 37774

    Etobicoke, Ontario, M8X 1E2

  • Site Reference ID/Investigator# 32871

    Etobicoke, Ontario, M9B 3Z9

  • Site Reference ID/Investigator# 32870

    Etobicoke, Ontario, M9V 5G4

  • Site Reference ID/Investigator# 32872

    Etobicoke, Ontario, M9V 5G4

  • Site Reference ID/Investigator# 32880

    Fonthill, Ontario, L0S 1E0

  • Site Reference ID/Investigator# 30873

    Fort Erie, Ontario, L2A 1Z3

  • Site Reference ID/Investigator# 31310

    Fort Erie, Ontario, L2A 1Z3

  • Site Reference ID/Investigator# 31356

    Fort Erie, Ontario, L2A 6E2

  • Site Reference ID/Investigator# 32182

    Gatineau, Quebec, J8X 4B6

  • Site Reference ID/Investigator# 37937

    Gatineau, Quebec, J8X 4B7

  • Site Reference ID/Investigator# 37843

    Gatineau, Quebec, J8Y 1W7

  • Site Reference ID/Investigator# 32910

    Gatineau, Quebec, J8Y 3B5

  • Site Reference ID/Investigator# 32911

    Gatineau, Quebec, J8Y 6S9

  • Site Reference ID/Investigator# 37941

    Gatineau, Quebec, J9J 2M9

  • Site Reference ID/Investigator# 31367

    Georgetown, Ontario, L7G 5E9

  • Site Reference ID/Investigator# 31381

    Georgetown, Ontario, L7G 5G1

  • Site Reference ID/Investigator# 30933

    Gimli, Manitoba, R0C 1B0

  • Site Reference ID/Investigator# 31393

    Grand-Mère, Quebec, G9T 2J1

  • Site Reference ID/Investigator# 31379

    Grand-Mère, Quebec, G9T 3S7

  • Site Reference ID/Investigator# 37852

    Grand-Mère, Quebec, G9T 3S7

  • Site Reference ID/Investigator# 32141

    Grand-Mère, Quebec, G9T 4T8

  • Site Reference ID/Investigator# 47572

    Grande-Allee, Quebec, J7G 1W6

  • Site Reference ID/Investigator# 37672

    Greater Sudbury, Ontario, L5B 6C3

  • Site Reference ID/Investigator# 37674

    Greater Sudbury, Ontario, P3A 1Y8

  • Site Reference ID/Investigator# 31271

    Greater Sudbury, Ontario, P3E 1A9

  • Site Reference ID/Investigator# 37784

    Greater Sudbury, Ontario, P3E 1B8

  • Site Reference ID/Investigator# 32529

    Greater Sudbury, Ontario, P3E 3C6

  • Site Reference ID/Investigator# 30904

    Greenfield Park, Quebec, J4V 2G8

  • Site Reference ID/Investigator# 30965

    Grimsby, Ontario, L3M 1P1

  • Site Reference ID/Investigator# 31285

    Grimsby, Ontario, L3M 1P3

  • Site Reference ID/Investigator# 42347

    Guelph, Ontario, N1E 6L9

  • Site Reference ID/Investigator# 42462

    Guelph, Ontario, N1H 5J1

  • Site Reference ID/Investigator# 31327

    Halifax, Nova Scotia, B3H 2Y1

  • Site Reference ID/Investigator# 31282

    Hamilton, Ontario, L8H 4R6

  • Site Reference ID/Investigator# 32223

    Hamilton, Ontario, L8J 0B6

  • Site Reference ID/Investigator# 42440

    Hamilton, Ontario, L8J 2N5

  • Site Reference ID/Investigator# 32214

    Hamilton, Ontario, L8K 3P3

  • Site Reference ID/Investigator# 30924

    Hamilton, Ontario, L8L 5G8

  • Site Reference ID/Investigator# 31348

    Hamilton, Ontario, L8L 5G8

  • Site Reference ID/Investigator# 30940

    Hamilton, Ontario, L8S 1C5

  • Site Reference ID/Investigator# 37907

    Hamilton, Ontario, L8S 1E7

  • Site Reference ID/Investigator# 31389

    Hamilton, Ontario, L9A 2G7

  • Site Reference ID/Investigator# 31275

    Hamilton, Ontario, L9A 5H4

  • Site Reference ID/Investigator# 32965

    Hawkesbury, Ontario, K6A 2R2

  • Site Reference ID/Investigator# 31373

    Hawkesbury, Ontario, K6A 3B2

  • Site Reference ID/Investigator# 32966

    Hébertville, Quebec, G8B 1N3

  • Site Reference ID/Investigator# 32167

    Hull, Quebec, J8Y 6S9

  • Site Reference ID/Investigator# 33002

    Jarvis, Ontario, N0A 1J0

  • Site Reference ID/Investigator# 30876

    Jordan Station, Ontario, L0R 1S0

  • Site Reference ID/Investigator# 37666

    Kamloops, British Columbia, V1S 1M9

  • Site Reference ID/Investigator# 30929

    Kamloops, British Columbia, V2B 3G9

  • Site Reference ID/Investigator# 32203

    Kamloops, British Columbia, V2C 5Y2

  • Site Reference ID/Investigator# 37882

    Kamloops, British Columbia, V3B 3G2

  • Site Reference ID/Investigator# 42365

    Kelowna, British Columbia, V1V 1A1

  • Site Reference ID/Investigator# 33018

    Kelowna, British Columbia, V1X 7N6

  • Site Reference ID/Investigator# 30915

    Kelowna, British Columbia, V1Y 8J8

  • Site Reference ID/Investigator# 33019

    Kensington, Prince Edward Island, C0B 1M0

  • Site Reference ID/Investigator# 37781

    Kentville, Nova Scotia, B4N 1M6

  • Site Reference ID/Investigator# 32611

    Keswick, Ontario, L4P 0A9

  • Site Reference ID/Investigator# 33020

    Keswick, Ontario, L4P 2C7

  • Site Reference ID/Investigator# 31386

    Kirkfield, Ontario, K0M 2B0

  • Site Reference ID/Investigator# 31298

    Kirkland, Quebec, H9J 2W2

  • Site Reference ID/Investigator# 42443

    Kitchener, Ontario, N2G 1E3

  • Site Reference ID/Investigator# 30895

    Kitchener, Ontario, N2G 4V4

  • Site Reference ID/Investigator# 37783

    Kitchener, Ontario, N2G 4V5

  • Site Reference ID/Investigator# 37906

    Kitchener, Ontario, N2M 5N6

  • Site Reference ID/Investigator# 42467

    Kitchener, Ontario, N2N 2A8

  • Site Reference ID/Investigator# 32189

    L'Anse-Saint-Jean, Quebec, G0V 1J0

  • Site Reference ID/Investigator# 42344

    La Baie, Quebec, G7B 0A3

  • Site Reference ID/Investigator# 42343

    La Malbaie, Quebec, G5A 1W7

  • Site Reference ID/Investigator# 32174

    La Salle, Ontario, N9J 2C1

  • Site Reference ID/Investigator# 37910

    La Salle, Ontario, N9J 2C1

  • Site Reference ID/Investigator# 42377

    Lachenaie, Quebec, J6V 1S8

  • Site Reference ID/Investigator# 30877

    Lachute, Quebec, J8H 1S4

  • Site Reference ID/Investigator# 33043

    Langley, British Columbia, V3A 4G5

  • Site Reference ID/Investigator# 31347

    LaSalle, Ontario, H8N 1X9

  • Site Reference ID/Investigator# 30968

    LaSalle, Quebec, H8N 1T5

  • Site Reference ID/Investigator# 30918

    LaSalle, Quebec, H8N 1X9

  • Site Reference ID/Investigator# 33042

    LaSalle, Quebec, N9J 2C1

  • Site Reference ID/Investigator# 33046

    Laval, Quebec, H7K 2J4

  • Site Reference ID/Investigator# 31397

    Laval, Quebec, H7L 3A2

  • Site Reference ID/Investigator# 37855

    Laval, Quebec, H7P 5L3

  • Site Reference ID/Investigator# 37856

    Laval, Quebec, H7P 5L3

  • Site Reference ID/Investigator# 42437

    Laval, Quebec, H7P 5L3

  • Site Reference ID/Investigator# 30871

    Laval, Quebec, H7V 2W2

  • Site Reference ID/Investigator# 42402

    Laval, Quebec, H7X 3S5

  • Site Reference ID/Investigator# 31362

    Lévis, Quebec, G0R 3E0

  • Site Reference ID/Investigator# 33062

    Lévis, Quebec, G6V 8V3

  • Site Reference ID/Investigator# 32220

    Lindsay, Ontario, K9V 5N7

  • Site Reference ID/Investigator# 42348

    Lindsay, Ontario, K9V 6C5

  • Site Reference ID/Investigator# 32196

    London, Ontario, N5V 2E3

  • Site Reference ID/Investigator# 30900

    London, Ontario, N5Y 3H9

  • Site Reference ID/Investigator# 33070

    London, Ontario, N6A 5G9

  • Site Reference ID/Investigator# 31333

    London, Ontario, N6C 4Y7

  • Site Reference ID/Investigator# 32148

    London, Ontario, N6E 3B9

  • Site Reference ID/Investigator# 31340

    London, Ontario, N6J 1Y4

  • Site Reference ID/Investigator# 31371

    Longueuil, Quebec, J4J 3X5

  • Site Reference ID/Investigator# 33072

    Lower Sackville, Nova Scotia, B4C 2N1

  • Site Reference ID/Investigator# 30894

    Lower Sackville, Nova Scotia, B4C 2R3

  • Site Reference ID/Investigator# 31315

    Maple Ridge, British Columbia, V2X 6A4

  • Site Reference ID/Investigator# 31385

    Markham, Ontario, L3P 5T7

  • Site Reference ID/Investigator# 33091

    Markham, Ontario, L3S 1R7

  • Site Reference ID/Investigator# 33090

    Markham, Ontario, L3S 3K9

  • Site Reference ID/Investigator# 42337

    Markham, Ontario, L6B 0P9

  • Site Reference ID/Investigator# 30957

    Marystown, Newfoundland and Labrador, A0E 2M0

  • Site Reference ID/Investigator# 33094

    Marystown, Newfoundland and Labrador, A0E 2M0

  • Site Reference ID/Investigator# 42461

    Middleton, Nova Scotia, B0S 1P0

  • Site Reference ID/Investigator# 30967

    Milton, Ontario, L9T 6R2

  • Site Reference ID/Investigator# 33104

    Mississauga, Ontario, L4T 4E3

  • Site Reference ID/Investigator# 42398

    Mississauga, Ontario, L4X 2Z9

  • Site Reference ID/Investigator# 33106

    Mississauga, Ontario, L4Y 2A6

  • Site Reference ID/Investigator# 30945

    Mississauga, Ontario, L5A 1W4

  • Site Reference ID/Investigator# 33105

    Mississauga, Ontario, L5B 3A8

  • Site Reference ID/Investigator# 37673

    Mississauga, Ontario, L5B 4M4

  • Site Reference ID/Investigator# 42331

    Mississauga, Ontario, L5B 4M4

  • Site Reference ID/Investigator# 42373

    Mississauga, Ontario, L5C 2R9

  • Site Reference ID/Investigator# 42468

    Mississauga, Ontario, L5C 2R9

  • Site Reference ID/Investigator# 32152

    Mississauga, Ontario, L5N 2W7

  • Site Reference ID/Investigator# 37723

    Mississauga, Ontario, L5N 4H4

  • Site Reference ID/Investigator# 37903

    Mississauga, Ontario, L5N 6S3

  • Site Reference ID/Investigator# 37904

    Mississauga, Ontario, L5N 6S3

  • Site Reference ID/Investigator# 31312

    Mississauga, Ontario, L5R 4B8

  • Site Reference ID/Investigator# 30909

    Mistassini, Quebec, G8L 5J8

  • Site Reference ID/Investigator# 32212

    Moncton, New Brunswick, E1C 1X6

  • Site Reference ID/Investigator# 37851

    Montreal, Quebec, H1L 2N9

  • Site Reference ID/Investigator# 31324

    Montreal, Quebec, H1T 1S6

  • Site Reference ID/Investigator# 31308

    Montreal, Quebec, H1T 2M4

  • Site Reference ID/Investigator# 33115

    Montreal, Quebec, H1V 1X4

  • Site Reference ID/Investigator# 42394

    Montreal, Quebec, H1W 1S5

  • Site Reference ID/Investigator# 30921

    Montreal, Quebec, H1X 1R6

  • Site Reference ID/Investigator# 31390

    Montreal, Quebec, H1X 1R6

  • Site Reference ID/Investigator# 33111

    Montreal, Quebec, H1X 1R6

  • Site Reference ID/Investigator# 33110

    Montreal, Quebec, H2N 2H7

  • Site Reference ID/Investigator# 42395

    Montreal, Quebec, H2S 2W1

  • Site Reference ID/Investigator# 30905

    Montreal, Quebec, H3K 1W7

  • Site Reference ID/Investigator# 33112

    Montreal, Quebec, H3L 2E8

  • Site Reference ID/Investigator# 30950

    Montreal, Quebec, H3M 3A9

  • Site Reference ID/Investigator# 31279

    Montreal, Quebec, H3M 3E2

  • Site Reference ID/Investigator# 31293

    Montreal, Quebec, H3M 3E2

  • Site Reference ID/Investigator# 31294

    Montreal, Quebec, H3S 1Z4

  • Site Reference ID/Investigator# 33114

    Montreal, Quebec, H3S 1Z6

  • Site Reference ID/Investigator# 33116

    Montreal, Quebec, H3S 2B2

  • Site Reference ID/Investigator# 31311

    Montreal, Quebec, H3Z 1X5

  • Site Reference ID/Investigator# 32158

    Montreal, Quebec, H4E 2K9

  • Site Reference ID/Investigator# 32154

    Mount Pearl, Newfoundland and Labrador, A1N 5K8

  • Site Reference ID/Investigator# 33193

    Mount Pearl, Newfoundland and Labrador, A1N 5K8

  • Site Reference ID/Investigator# 42327

    Nepean, Ontario, K2G 1W2

  • Site Reference ID/Investigator# 31364

    Nepean, Ontario, K2H 9A5

  • Site Reference ID/Investigator# 31334

    Nepean, Ontario, K2J 3Z6

  • Site Reference ID/Investigator# 31357

    Newboro, Ontario, K0G 1P0

  • Site Reference ID/Investigator# 42445

    Newcastle, Ontario, L1B 1H8

  • Site Reference ID/Investigator# 37770

    Newmarket, Ontario, L3Y 2N1

  • Site Reference ID/Investigator# 30970

    Newmarket, Ontario, L3Y 5G8

  • Site Reference ID/Investigator# 31388

    Newmarket, Ontario, L3Y 5G8

  • Site Reference ID/Investigator# 37930

    Newmarket, Ontario, L3Y 7V1

  • Site Reference ID/Investigator# 32172

    Niagara Falls, Ontario, L2G 6B9

  • Site Reference ID/Investigator# 33232

    North Battleford, Saskatchewan, S9A 0V6

  • Site Reference ID/Investigator# 33233

    North Battleford, Saskatchewan, S9A 0V6

  • Site Reference ID/Investigator# 31366

    North Battleford, Saskatchewan, S9A 3G8

  • Site Reference ID/Investigator# 31326

    North Bay, Ontario, P1B 0A7

  • Site Reference ID/Investigator# 30913

    North Bay, Ontario, P1B 8G1

  • Site Reference ID/Investigator# 33234

    North Vancouver, British Columbia, V7M 2K2

  • Site Reference ID/Investigator# 30937

    North York, Ontario, M2J 2Z1

  • Site Reference ID/Investigator# 32601

    North York, Ontario, M2N 7J5

  • Site Reference ID/Investigator# 32602

    North York, Ontario, M2N 7J5

  • Site Reference ID/Investigator# 42442

    North York, Ontario, M3B 2W7

  • Site Reference ID/Investigator# 30896

    North York, Ontario, M3C 1T2

  • Site Reference ID/Investigator# 31265

    North York, Ontario, M3C 1T2

  • Site Reference ID/Investigator# 32607

    North York, Ontario, M3J 1N2

  • Site Reference ID/Investigator# 42407

    North York, Ontario, M3N 2K1

  • Site Reference ID/Investigator# 42435

    North York, Ontario, M3N 2Z9

  • Site Reference ID/Investigator# 33235

    North York, Ontario, M9N 1X2

  • Site Reference ID/Investigator# 31350

    Oakville, Ontario, L6H 3P1

  • Site Reference ID/Investigator# 37842

    Oakville, Ontario, L6H 3P1

  • Site Reference ID/Investigator# 30910

    Oshawa, Ontario, L1H 1B9

  • Site Reference ID/Investigator# 30971

    Oshawa, Ontario, L1H 1B9

  • Site Reference ID/Investigator# 42459

    Oshawa, Ontario, L1H 1B9

  • Site Reference ID/Investigator# 42415

    Oshawa, Ontario, L1H 1G4

  • Site Reference ID/Investigator# 32162

    Oshawa, Ontario, L1H 7K4

  • Site Reference ID/Investigator# 33260

    Oshawa, Ontario, L1H 7K4

  • Site Reference ID/Investigator# 42363

    Oshawa, Ontario, L1H 7K4

  • Site Reference ID/Investigator# 32164

    Oshawa, Ontario, L1J 2K1

  • Site Reference ID/Investigator# 32185

    Ottawa, Ontario, K1H 1A2

  • Site Reference ID/Investigator# 37884

    Ottawa, Ontario, K1H 1A2

  • Site Reference ID/Investigator# 32422

    Ottawa, Ontario, K1K 4L2

  • Site Reference ID/Investigator# 33267

    Ottawa, Ontario, K1L 8M3

  • Site Reference ID/Investigator# 42425

    Ottawa, Ontario, K1Z 7K8

  • Site Reference ID/Investigator# 32190

    Ottawa, Ontario, K2A 3V5

  • Site Reference ID/Investigator# 31380

    Ottawa, Ontario, K2B 7Z2

  • Site Reference ID/Investigator# 31287

    Ottawa, Ontario, K2C 0C7

  • Site Reference ID/Investigator# 33266

    Ottawa, Ontario, K2C 0C7

  • Site Reference ID/Investigator# 31301

    Ottawa, Ontario, K2G 3Y5

Other trials in Canada

About this study

Official title: A Prospective, Non-interventional, Observational Study To Describe the Effectiveness of Trandolapril (Mavik®) in the Management of Patients Requiring Angiotensin Converting Enzyme Inhibitor Treatment (In-MAU-tion)

The in-MAU-tion study is conducted to determine the percentage of hypertensive participants with or without diabetes reaching CHEP (Canadian Hypertension Education Program) defined blood pressure targets. Additionally, the study assesses change in renal function (microalbuminuria, estimated glomerular filtration rate) in hypertensive participants treated with trandolapril (Mavik®) and examines patient satisfaction with trandolapril (Mavik®) therapy.

Read the detailed description

There are no interventional implications in this study. The study runs under consideration of Canadian Hypertension Education Program guidelines and as per standard practice of care. Data collection is recorded on the appropriate case report forms. The data collected consist of: patient demographics (gender, race, age, weight), blood pressure readings, heart rate, coexisting comorbidities, concomitant chronic medications (generic name and dosage), indication and dose for trandolapril (Mavik®) and patient compliance. Laboratory values (microalbuminuria, estimated glomerular filtration rate) are only collected if the data are available for each patient. For baseline values (study Day 0), any laboratory value recorded within the past year prior to the baseline visit (Visit 1) is recorded, if the value is available. As per Canadian Hypertension Education Program recommendations and as a support and educational measure, patients are provided with (1) educational tools (nutrition guidebooks) and (2) home blood pressure monitoring devices. As per research and development guidelines, blood pressure devices were retrieved at the end of the study. Approximately 8,000 hypertensive participants were enrolled in the study at up to 700 sites across Canada. Sample size estimations were based on the assumption that 67.2% of non-diabetic hypertensive participants (assumed to make up to 69% of the eligible participant population) would reach a blood pressure target of <140/90mm Hg, while 22% of diabetes participants (31% of the eligible population) would meet a blood pressure target of <130/80 mm Hg with trandolapril (Mavik®) therapy.

Conditions
Hypertension
Keywords
Uncontrolled hypertension, trandolapril
Medical subject headings
Hypertension

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT01078584
Study groupRoleWhat they receive
Hypertensive ParticipantsHypertensive diabetics and non-diabetics, with or without isolated systemic hypertension and/or renal dysfunction, who were naïve to trandolapril or on trandolapril within past 30 days.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percentage of Non-Diabetic and Diabetic Participants Meeting Blood Pressure Targets at 3 Months

    Blood pressure (BP) targets, as specified in the 2008 CHEP recommendations, were systolic BP (SBP)/diastolic BP (DBP) <140/90 mm Hg for non-diabetic participants, and SBP/DBP <130/80 mm Hg for diabetic participants.

    Measured: 3 months

  2. Percentage of Non-Diabetic and Diabetic Participants Meeting Blood Pressure Targets at 6 Months

    Blood pressure (BP) targets, as specified in the 2008 CHEP recommendations, were systolic BP (SBP)/diastolic BP (DBP) <140/90 mm Hg for non-diabetic participants, and SBP/DBP <130/80 mm Hg for diabetic participants.

    Measured: 6 months

  3. Percentage of Non-Diabetic and Diabetic Participants Meeting Blood Pressure Targets at 12 Months

    Blood pressure (BP) targets, as specified in the 2008 CHEP recommendations, were systolic BP (SBP)/diastolic BP (DBP) <140/90 mm Hg for non-diabetic participants, and SBP/DBP <130/80 mm Hg for diabetic participants.

    Measured: 12 months

Secondary outcomes (11)

  1. Change From Baseline in Estimated Glomerular Filtration Rate (eGFR) in Blood Pressure (BP)-Controlled and BP-Uncontrolled Diabetics at 3 Months

    Diabetics were considered to be "BP-controlled" if BP <130/80 mm Hg. Diabetics were considered to be "BP-uncontrolled" if BP >/=130/80 mm Hg.

    Measured: Baseline, 3 Months

  2. Change From Baseline in Estimated Glomerular Filtration Rate (eGFR) in Blood Pressure (BP)-Controlled and BP-Uncontrolled Diabetics at 6 Months

    Diabetics were considered to be "BP-controlled" if BP <130/80 mm Hg. Diabetics were considered to be "BP-uncontrolled" if BP >/=130/80 mm Hg.

    Measured: Baseline, 6 Months

  3. Change From Baseline in Estimated Glomerular Filtration Rate (eGFR) in Blood Pressure (BP)-Controlled and BP-Uncontrolled Diabetics at 12 Months

    Diabetics were considered to be "BP-controlled" if BP <130/80 mm Hg. Diabetics were considered to be "BP-uncontrolled" if BP >/=130/80 mm Hg.

    Measured: Baseline,12 Months

  4. Change From Baseline in Microalbuminuria (MAU) at 3 Months

    Measured: Baseline, 3 Months

  5. Change From Baseline in Microalbuminuria (MAU) at 6 Months

    Measured: Baseline, 6 Months

  6. Change From Baseline in Microalbuminuria (MAU) at 12 Months

    Measured: Baseline, 12 months

  7. Percentage of Participants With Isolated Systolic Hypertension (ISH) Reaching 2008 CHEP Systolic Blood Pressure (BP) Target After 3 Months of Therapy

    The 2008 CHEP systolic BP (SBP) target is <140 mm Hg. Where a participant had an SBP less than the target, the participant's SBP was defined as "controlled."

    Measured: 3 Months

  8. Percentage of Participants With Isolated Systolic Hypertension (ISH) Reaching 2008 CHEP Systolic Blood Pressure (BP) Target After 6 Months of Therapy

    The 2008 CHEP systolic BP (SBP) target is <140 mm Hg. Where a participant had an SBP less than the target, the participant's SBP was defined as "controlled."

    Measured: 6 Months

  9. Percentage of Participants With Isolated Systolic Hypertension (ISH) Reaching 2008 CHEP Systolic Blood Pressure (BP) Target After 12 Months of Therapy

    The 2008 CHEP systolic BP (SBP) target is <140 mm Hg. Where a participant had an SBP less than the target, the participant's SBP was defined as "controlled."

    Measured: 12 Months

  10. Percentage of Participants Reporting Defined Levels of Satisfaction With Current Therapy at Baseline and After 12 Months of Therapy

    Satisfaction with therapy at baseline (BL) and 12 months, using a 5-point Likert scale where participants responded to the question "Are you satisfied with your current hypertension therapy?". The range of responses varied from "1 = not at all satisfied" to "5 = extremely satisfied." Responses "2" through "4" were not otherwise defined, but represented increments of more or less satisfaction with current therapy, respectively.

    Measured: Day 0 (Baseline), 12 months

  11. Percentage of Participants Reporting Defined Levels of Satisfaction With Current Therapy at Baseline Versus After 12 Months of Therapy

    Satisfaction with therapy at baseline (BL) versus 12 months, using a 5-point Likert scale where participants responded to the question "Are you satisfied with your current hypertension therapy?". The range of responses varied from "1 = not at all satisfied" to "5 = extremely satisfied." Responses "2" through "4" were not otherwise defined, but represented increments of more or less satisfaction with current therapy, respectively.

    Measured: Day 0 (Baseline), 12 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted2 Mar 2010 (estimated)
  2. Study startDec 2008
  3. Primary completionSep 2011
  4. Study completionSep 2011

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
7,993 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT01078584
Sponsor's protocol ID
P10-665
Acronym
in-MAU-tion
Status last verified
Oct 2012
First submitted
1 Mar 2010
Last updated
25 Oct 2012

Questions about this trial

What is this clinical trial studying?

An observational study of Hypertension, run by Abbott at 568 sites in Canada.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 25 Oct 2012. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 568 sites in Canada. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

Yes. Results are posted in the registry (first posted 11 Oct 2012). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percentage of Non-Diabetic and Diabetic Participants Meeting Blood Pressure Targets at 3 Months (time frame: 3 months). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT01078584.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 25 Oct 2012.

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