HealthyMOMICNCT01075061
Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification PROJET " MOMIC "
A study testing healthy volunteers, Kallmann and Congenital Mirror Movement in people with Healthy, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
Trial summary
Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. Read more about this study
- Who is it for?
- Ages 11 to 82 yearsHealthy volunteers can take part
- Conditions the study is for
- Healthy
- What is being tested?
- healthy volunteers, Kallmann and Congenital Mirror Movement
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 40 participants
- Where
- 1 siteFrance
- Study dates
- Feb 2010to Jul 2011
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 11 to 82 years
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Who may be able to join
- Patients aged from 11 to 82 years
- Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
- No contraindication for MRI or TMS study
Who cannot join
- inability to provide an informed consent
- Simultaneous participation in another clinical trial
- Treatment that modulate cortical excitability (for the TMS part of the study only)
Trial locations and contacts
1 site in 1 country.
France1 site
Fédération des Maladies du Système Nerveux, Hôpital Pitié Salpétrière
Paris, 75013
About this study
Official title: Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC
Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.
- Conditions
- Healthy
- Being tested
- healthy volunteers, Kallmann, Congenital Mirror Movement
- Keywords
- Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
healthy volunteersOther
morphological and functional brain MRI; transcranial magnetic stimulation
KallmannOther
morphological and functional brain MRI; transcranial magnetic stimulation
Congenital Mirror MovementOther
morphological and functional brain MRI; transcranial magnetic stimulation
| Study group | Role | What they receive |
|---|---|---|
| healthy volunteers | Other | healthy volunteers Receives: Other: healthy volunteers |
| Kallmann | Other | Kallmann syndrome patients Receives: Other: Kallmann |
| Congenital Mirror Movement | Other | patients with CMM Receives: Other: Congenital Mirror Movement |
What is being measured
The primary outcome is the main question the study is designed to answer.
- To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM
Measured: 08/2011
Secondary outcomes (1)
- To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis
Measured: 08/2011
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Feb 2010 (estimated)
- Study startFeb 2010
- Primary completionJul 2011
- Study completionJul 2011
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- More trials run by Institut National de la Santé Et de la Recherche Médicale, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 40 participants (actual)
Sponsor and investigators
- Sponsor type
- Other government
- Responsible party
- Sponsor
- Investigators
- Emmanuel ROZE, MD, Principal investigator, Institut National de la Santé Et de la Recherche Médicale, France
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01075061
- Sponsor's protocol ID
- C09-06
- Other IDs
- 2009-A00490-57
- Acronym
- MOMIC
- Status last verified
- Feb 2016
- First submitted
- 4 Feb 2010
- Last updated
- 27 Aug 2025
- Results posted
- No
- Data monitoring committee
- No
Publications
Depienne C, Cincotta M, Billot S, Bouteiller D, Groppa S, Brochard V, Flamand C, Hubsch C, Meunier S, Giovannelli F, Klebe S, Corvol JC, Vidailhet M, Brice A, Roze E. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology. 2011 Jan 18;76(3):260-4. doi: 10.1212/WNL.0b013e318207b1e0.
PubMed 21242494
Study at a glance
From the registry record, last updated by the sponsor on 27 Aug 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of a Large Family With Congenital Mirror Movements : From Underlying Pathophysiology to Culprit Gene Identification : MOMIC
- ClinicalTrials.gov ID
- NCT01075061
- Acronym / sponsor ID
- MOMIC / C09-06
- Conditions
- Healthy
- Keywords
- Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 40 participants (actual)
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, FranceOther government
- Study start
- Feb 2010
- Primary completion
- Jul 2011 (actual)
- Study completion
- Jul 2011 (actual)
- First posted
- 24 Feb 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.
Study design
- Primary purpose
- Basic science
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| healthy volunteers | Other | Other: healthy volunteershealthy volunteers |
| Kallmann | Other | Other: KallmannKallmann syndrome patients |
| Congenital Mirror Movement | Other | Other: Congenital Mirror Movementpatients with CMM |
Who may qualify
- Ages
- 11 to 82 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (3 listed)
- Patients aged from 11 to 82 years
- Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements.
- No contraindication for MRI or TMS study
Key exclusion criteria (3 listed)
- inability to provide an informed consent
- Simultaneous participation in another clinical trial
- Treatment that modulate cortical excitability (for the TMS part of the study only)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| healthy volunteersmorphological and functional brain MRI; transcranial magnetic stimulation | Other | healthy volunteers |
| Kallmannmorphological and functional brain MRI; transcranial magnetic stimulation | Other | Kallmann |
| Congenital Mirror Movementmorphological and functional brain MRI; transcranial magnetic stimulation | Other | Congenital Mirror Movement |
Primary outcome
- To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM
Time frame: 08/2011
1 secondary outcome
- To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis
Time frame: 08/2011
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Aug 2025.
- Results publication: PubMed 21242494Depienne C, Cincotta M, Billot S, Bouteiller D, Groppa S, Brochard V, Flamand C, Hubsch C, Meunier S, Giovannelli F, Klebe S, Corvol JC, Vidailhet M, Brice A, Roze E. A novel DCC mutation and genetic heterogeneity in congenital mirror movements. Neurology. 2011 Jan 18;76(3):260-4. doi: 10.1212/WNL.0b013e318207b1e0.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Emmanuel ROZE, MD principal investigator
Institut National de la Santé Et de la Recherche Médicale, France
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing healthy volunteers, Kallmann and Congenital Mirror Movement in people with Healthy, run by Institut National de la Santé Et de la Recherche Médicale, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Aug 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
- To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM (time frame: 08/2011). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT01075061, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Aug 2025.