AgingCEENCT00988299
Energy Expenditure Responses to Acute Exercise in Older Women (Calorie Expenditure and Exercise)
A study testing exercise in people with Aging, run by Washington University School of Medicine at 1 site in United States.
Trial summary
In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential: 1. Read more about this study
- Who is it for?
- Ages 60 to 75 years, women onlyHealthy volunteers can take part
- Conditions the study is for
- Aging
- What is being tested?
- exercise
- How many people
- 26 participants
- Where
- 1 siteUnited States
- Study dates
- Oct 2009to Dec 2011
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 75 years
- Women only
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Women
- Age 60-75 years
- normal weight
- Weight-stable (± 5%) within the previous 3 months
- Non-smoking for last year
- Able to provide own transportation to study visits
Show all 9Show fewer
- Not currently involved in any other research study
- Willing and able to participate in all aspects of the trial including research testing
- Willing to give informed consent to participate
Who cannot join
- Self-reported significant cardiovascular disease
- Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
- Medications known to affect exercise performance or metabolism
- Excess caffeine use (> 500mg/day)
- Any self-reported contraindications to exercise
- Clinical depression
- Abnormal cognitive function -
Trial locations and contacts
1 site in 1 country.
United States1 site
Washington University School of Medicine
St Louis, Missouri, 63110
About this study
Official title: Energy Expenditure Responses to Acute Exercise in Older Women
In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:
- decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
- increase in resting metabolic rate 48 hours after exercise;
- increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
- decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.
- Conditions
- Aging
- Being tested
- exercise
- Keywords
- older, NEAT, exercise, RMR, energy expenditure
- Medical subject headings
- Motor Activity
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
exerciseOther
exercise sessions at 45% and 60% of maximum effort
What is being measured
The primary outcome is the main question the study is designed to answer.
non-exercise activity calorie expenditure
Measured: 2 days after exercise sessions
Secondary outcomes (1)
resting metabolic rate
Measured: 2 days after exercise sessions
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2009 (estimated)
- Study startOct 2009
- Primary completionDec 2011
- Study completionDec 2011
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AgingStudies of the same condition, open and under way.
- More trials run by Washington University School of MedicineThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
- Enrolment
- 26 participants (actual)
Sponsor and investigators
- Lead sponsor
- Washington University School of Medicine
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Responsible party
- Sponsor
- Investigators
- Xuewen Wang, PhD, Principal investigator, Washington University School of Medicine
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00988299
- Sponsor's protocol ID
- 09-0864
- Other IDs
- K99AG031297
- Acronym
- CEE
- Status last verified
- Dec 2011
- First submitted
- 1 Oct 2009
- Last updated
- 6 Dec 2011
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 6 Dec 2011. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Energy Expenditure Responses to Acute Exercise in Older Women
- ClinicalTrials.gov ID
- NCT00988299
- Acronym / sponsor ID
- CEE / 09-0864
- Conditions
- Aging
- Keywords
- older, NEAT, exercise, RMR, energy expenditure
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 26 participants (actual)
- Lead sponsor
- Washington University School of MedicineUniversity, hospital or other
- Collaborators
- National Institute on Aging (NIA)
- Study start
- Oct 2009
- Primary completion
- Dec 2011 (actual)
- Study completion
- Dec 2011 (actual)
- First posted
- 2 Oct 2009 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In older, normal-weight women (60-75 yrs, BMI=18-28 kg/m2), an acute bout of higher-intensity (60% of maximum effort) aerobic exercise, in comparison to an isocaloric bout of lower-intensity (45% of maximum effort) exercise (caloric expenditure of 3.5 kcal/kg body weight for both), will result in differential:
- decline in non-exercise activity calorie expenditure in the subsequent 48 hours after exercise;
- increase in resting metabolic rate 48 hours after exercise;
- increase in serum free triiodo-L-thyronine (free T3) concentrations immediately following exercise;
- decline from pre-exercise in plasma leptin and serum free T3 concentrations 48 hours after exercise.
Study design
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- None (open label)
Who may qualify
- Ages
- 60 to 75 years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (9 listed)
- Women
- Age 60-75 years
- normal weight
- Weight-stable (± 5%) within the previous 3 months
- Non-smoking for last year
Key exclusion criteria (7 listed)
- Self-reported significant cardiovascular disease
- Other self-reported medical conditions such as diabetes, chronic or recurrent respiratory conditions, active cancer, musculoskeletal disease
- Medications known to affect exercise performance or metabolism
- Excess caffeine use (> 500mg/day)
- Any self-reported contraindications to exercise
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| exerciseexercise sessions at 45% and 60% of maximum effort | Other | – |
Primary outcome
non-exercise activity calorie expenditure
Time frame: 2 days after exercise sessions
1 secondary outcome
resting metabolic rate
Time frame: 2 days after exercise sessions
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Dec 2011.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Xuewen Wang, PhD principal investigator
Washington University School of Medicine
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing exercise in people with Aging, run by Washington University School of Medicine at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 9 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 6 Dec 2011. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
non-exercise activity calorie expenditure (time frame: 2 days after exercise sessions). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Dec 2011.