AzTrials
AzTrials

Atrial FibrillationPhase 3ARISTOTLENCT00412984

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation

A Phase 3 study testing warfarin and apixaban in people with Atrial Fibrillation and Atrial Flutter, run by Bristol-Myers Squibb at 1,111 sites in 41 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
Search all trials

Trial summary

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke. Read more about this study

Who is it for?
Any age
Conditions the study is for
Atrial Fibrillation, Atrial Flutter
What is being tested?
warfarin and apixaban
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
20,976 participants
Where
1,111 sitesin 41 countries
Study dates
31 Dec 2006to 25 May 2011
Phase
Phase 3
Are there results?
Yes, posted in the registrySummary in the doctors' view

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages Any age
  • All sexes
  • No healthy volunteers
  • Child, Adult, Older adult

Who may be able to join

  • Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:
  • Age ≥ 75, previous stroke
  • transient ischemic attack (TIA) or Systemic Embolism (SE)
  • Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%
  • Diabetes mellitus or hypertension requiring pharmacological treatment

Who cannot join

None listed.

Trial locations and contacts

1,111 sites in 41 countries.

1111 sites in 41 countries

United States284 sites

  • Abington Medical Specialists

    Abington, Pennsylvania, 19001

  • Akron Cardiology Consultants

    Akron, Ohio, 44304

  • Albany Assoc. In Cardiology

    Albany, New York, 12205

  • Albany Associates In Cardiology

    Albany, New York, 12205

  • Abq Health Partners, Llc

    Albuquerque, New Mexico, 87012

  • University Of New Mexico/University Hospital

    Albuquerque, New Mexico, 87131-0001

  • University Of New Mexico/University Hospital

    Albuquerque, New Mexico, 87131

  • Alexandria Cardiology Clinic

    Alexandria, Louisiana, 71301

  • Great Lakes Heart Center Of Alpena

    Alpena, Michigan, 49707

  • Blair Medical Associates, Inc.

    Altoona, Pennsylvania, 16602

  • Amarillo Heart Clinical Research Institute Inc.

    Amarillo, Texas, 79106

  • Mcfarland Clinic Pc

    Ames, Iowa, 50010

  • Advanced Clinical Reserach Institute

    Anaheim, California, 92801

  • Alaska Heart Institute

    Anchorage, Alaska, 99508

  • Community Clinical Research Center

    Anderson, Indiana, 46011

  • Southeastern Research Associates, Inc

    Anderson, South Carolina, 29621

  • Asheville Cardiology Associates

    Asheville, North Carolina, 28803

  • Cardiovascular Specialits, Pc

    Atlanta, Georgia, 30342

  • Medical Specialist Of The Palm Beach

    Atlantis, Florida, 33462

  • Augusta Cardiology Clinic, P.C.

    Augusta, Georgia, 30901

  • Fox Valley Clinical Research Center, Llc

    Aurora, Illinois, 60504

  • Miami International Cardiology Consultants

    Aventura, Florida, 33180

  • Midatlantic Cardiovascular Associates, P.A.

    Baltimore, Maryland, 21204

  • Midatlantic Cardiovascular Associates, Pa

    Baltimore, Maryland, 21208

  • Midatlantic Cardiovascular Associates, P.A.

    Baltimore, Maryland, 21218

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224-2735

  • Johns Hopkins Bayview Medical Center

    Baltimore, Maryland, 21224

  • Franklin Square Hospital

    Baltimore, Maryland, 21237

  • Midatlantic Cardiovascular Associates, P.A.

    Baltimore, Maryland, 21237

  • Midatlantic Cardiovascular Associates, Pa

    Baltimore, Maryland, 21237

  • Lowcountry Medical Group, Llc

    Beaufort, South Carolina, 29906

  • Lowcountry Medical Group

    Beaufort, South Carolina, 29906

  • Midatlantic Cardiovascular Associates, Pa

    Bel Air, Maryland, 21014

  • St. Charles Health System, Inc.

    Bend, Oregon, 97701

  • St. Charles Health System, Inc

    Bend, Oregon, 97701

  • Comprehensive Clinical Research

    Berlin, New Jersey, 08009

  • Act/Cardiovascular Research Institute

    Beverly Hills, California, 90210

  • Burlington Medical Associates

    Billerica, Massachusetts, 01821

  • Cardiology Associates, Pc

    Binghamton, New York, 13905

  • Cardiovascular Associates, Pc

    Birmingham, Alabama, 35209

  • Alabama Internal Medicine Pc

    Birmingham, Alabama, 35235

  • Birmingham Heart Clinic P.C.

    Birmingham, Alabama, 35235

  • Premier Healthcare, Llc

    Bloomington, Indiana, 47403

  • David Charles Mishkel, Md, Pa

    Boca Raton, Florida, 33431

  • Caritas St. Elizabeth'S Medical Center

    Boston, Massachusetts, 02135

  • Connecticut Clinical Research, Llc

    Bridgeport, Connecticut, 06606

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610

  • Holston Medical Group

    Bristol, Tennessee, 37620

  • Christopher M. Johnson, D.O.

    Bucyrus, Ohio, 44820

  • Christopher M. Johnson, D.O.

    Bucyrus, Ohio, OHIO

  • Buffalo Heart Group, Llp

    Buffalo, New York, 14215-1145

  • Bruce L. Platt Md, Pc

    Buffalo, New York, 14215

  • Bruce L. Platt, Md

    Buffalo, New York, 14215

  • Buffalo Heart Group, Llp

    Buffalo, New York, 14215

  • Daniel W. Gottlieb, Md, Ps

    Burien, Washington, 98166

  • Daniel William Gottlieb, Md

    Burien, Washington, 98166

  • Lahey Clinic Medical Center

    Burlington, Massachusetts, 01805

  • Kernodle Clinic, Inc.

    Burlington, North Carolina, 27215

  • Heritage Cardiology Assoc.

    Camp Hill, Pennsylvania, 17011

  • Community Health Care, Inc.

    Canal Fulton, Ohio, 44614

  • Cardiology Associates

    Canton, Ohio, 44710

  • Capitol Interventional Cardiology

    Carmichael, California, 95608

  • Medical University Of South Carolina

    Charleston, South Carolina, 29425

  • Nmff

    Chicago, Illinois, 60611

  • The Carl & Edyth Lindner Center For R&E At The Christ Hosp

    Cincinnati, Ohio, 45219

  • The Heart & Vascular Institute Of Florida

    Clearwater, Florida, 33756

  • The Heart And Vascular Institute Of Florida

    Clearwater, Florida, 33756

  • Electrophysiology Associates, Pc

    Colorado Springs, Colorado, 80910

  • Cardiovascular Specialists Of Central Maryland, P.A.

    Columbia, Maryland, 21044

  • University Of Missouri

    Columbia, Missouri, 65212

  • Columbia Heart Clinic

    Columbia, South Carolina, 29203

  • Columbus Cardiology Associates Pc

    Columbus, Georgia, 31909

  • Columbus Cardiology Associates,Pc

    Columbus, Georgia, 31909

  • Corsicana Medical Research, Pllc

    Corsicana, Texas, 75110

  • Georgia Heart Specialists, L.L.C.

    Covington, Georgia, 30014

  • Soltero Cardiovascular Research Center

    Dallas, Texas, 75226

  • Heartplace

    Dallas, Texas, 75230

  • Cardiovascular Specialist Of South Florida

    Davie, Florida, 33324

  • Daytona Heart Group

    Daytona Beach, Florida, 32114

  • Atlanta Institute For Medical Research, Inc

    Decatur, Georgia, 30030

  • Aurora Denver Cardiology Associates, P.C.

    Denver, Colorado, 80218

  • Denver Va Medical Center

    Denver, Colorado, 80220

  • Henry Ford Hospital

    Detroit, Michigan, 48202

  • Central Bucks Cardiology

    Doylestown, Pennsylvania, 18901

  • Heart Care Center, P.C.

    East Syracuse, New York, 13057

  • Central Cardiology Assoc.

    Elizabethtown, Kentucky, 42701

  • Elkhart Clinic, Llc

    Elkhart, Indiana, 46514

  • Cardiovascular Associates Of The Delware Valley, P.A.

    Elmer, New Jersey, 08318

  • Internal Medicine And Lipid Mgmt.

    Erie, Pennsylvania, 16509

  • Escondido Cardiology Associates, Inc.

    Escondido, California, 92025

  • Oregon Medical Group - Clinical Research

    Eugene, Oregon, 97401

  • Neccr Internal Medicine & Cardiology Associates,Llc

    Fall River, Massachusetts, 02720

  • Lillestol Research Llc

    Fargo, North Dakota, 58103

  • Cardiology Associates Of Fort Lauderdale, P.A.

    Fort Lauderdale, Florida, 33308

  • Broward General Medical Center

    Fort Lauderdale, Florida, 33316

  • Florida Heart Associates

    Fort Myers, Florida, 33907

  • Lutheran Medical Group, Llc

    Fort Wayne, Indiana, 46804

  • Fort Wayne Cardiology

    Fort Wayne, Indiana, 46805

  • Heart Center Of North Texas

    Fort Worth, Texas, 76104

  • Florida Research Network, Llc

    Gainesville, Florida, 32605

  • Northeast Georgia Heart Center, Pc

    Gainesville, Georgia, 30501

  • New West Physicians Clinical Research

    Golden, Colorado, 80401

  • Internal Medical Associates of Grand Island, P.C

    Grand Island, Nebraska, 68803-4311

  • Internal Medical Associates Of Grand Island, P.C

    Grand Island, Nebraska, 68803

  • Cardiology Associates Of Green Bay Ltd-Bellin Hospital

    Green Bay, Wisconsin, 54301

  • Upstate Cardiology

    Greenville, South Carolina, 29607

  • Internal Medicine Of Greer

    Greer, South Carolina, 29650

  • Cardiology Associates Of New Haven,Pc

    Guilford, Connecticut, 06437

  • Clinical Investigation Specialists, Inc

    Gurnee, Illinois, 60031

  • Cardiovascular Associates Of The Delaware Valley, P.A.

    Haddon Heights, New Jersey, 08035

  • Kandra, Fierer, Kuskin Associates

    Harrisburg, Pennsylvania, 17112

  • Nebraska Heart Institute

    Hastings, Nebraska, 68901

  • Pivotal Clinical Research, Llc

    Hatfield, Pennsylvania, 19440

  • Pentucket Medical Associates

    Haverhill, Massachusetts, 01830-6278

  • Pentucket Medical Associates

    Haverhill, Massachusetts, 01830

  • William D. Bowden, D.O.

    Healdsburg, California, 95448

  • Carolina Cardiology Associates, Pa

    High Point, North Carolina, 27262

  • Hillsboro Cardiology Pc

    Hillsboro, Oregon, 97123

  • Healthworx

    Hollywood, Florida, 33021

  • Luis Tami, Md

    Hollywood, Florida, 33021

  • Dr. Rajesh Shroff

    Hot Springs, Arkansas, 71913

  • Cardiovascular Institute Of The South

    Houma, Louisiana, 70360

  • Center For Atrial Fibrillation

    Houston, Texas, 77030

  • The Methodist Hospital Neurology Institute

    Houston, Texas, 77030

  • The Methodist Hospital

    Houston, Texas, 77030

  • The University Of Texas Md Anderson Cancer Center

    Houston, Texas, 77030

  • Northwest Houston Cardiology, Pa

    Houston, Texas, 77065

  • Northwest Houston Cardiology, Pa

    Houston, Texas, 77070

  • Francisco R. Maislos

    Houston, Texas, 77074

  • Woodlands North Houston Heart Center

    Houston, Texas, 77090

  • Regional Medical Center And Diagnostic Clinics

    Humble, Texas, 77338

  • Huntington Hospital

    Huntington, New York, 11743

  • Heart Center, Inc.

    Huntsville, Alabama, 35801

  • St Francis Medical Group - Indiana Heart Physicians

    Indianapolis, Indiana, 46237

  • The Care Group, Llc.

    Indianapolis, Indiana, 46290

  • The Care Group, Llc

    Indianapolis, Indiana, 46290

  • Nature Coast Clinical Research

    Inverness, Florida, 34452

  • St. Vincent'S Ambulatory Care, Inc

    Jacksonville, Florida, 32204

  • Jacksonville Heart Center, Pa

    Jacksonville, Florida, 32207

  • Jacksonville Cardiovascular Center

    Jacksonville, Florida, 32216

  • Jacksonville Center For Clinical Research

    Jacksonville, Florida, 32216

  • St. Luke'S Cardiology

    Jacksonville, Florida, 32216

  • Jacksonville Heart Center, Pa

    Jacksonville, Florida, 32258

  • Jacksonville Heart Center, P.A.

    Jacksonville Beach, Florida, 32250

  • Lycoming Internal Medicine Inc.

    Jersey Shore, Pennsylvania, 17740

  • Cvms Research Institute, Llc

    Jupiter, Florida, 33458

  • Ricardo Bedoya, M.D.

    Jupiter, Florida, 33458

  • Truman Medical Center

    Kansas City, Missouri, 64108

  • Saint Luke'S Lipid And Diabetes Research Center

    Kansas City, Missouri, 64111

  • Holston Medical Group

    Kingsport, Tennessee, 37660

  • Knoxville Heart Group

    Knoxville, Tennessee, 37916

  • Volunteer Research Group

    Knoxville, Tennessee, 37920-1502

  • Volunteer Research Group

    Knoxville, Tennessee, 37920

  • La Mesa Cardiac Center, A Medical Group

    La Mesa, California, 91942

  • Wilford Hall Medical Center

    Lackland Air Force Base, Texas, 78236-9908

  • Wilford Hall Medical Center

    Lackland Air Force Base, Texas, 78236

  • Smith, Patel & Amkieh, Llc

    Lacombe, Louisiana, 70445

  • Imperial Calcasieu Medical Group, Llp

    Lake Charles, Louisiana, 70601

  • Thoracic And Cardiovascular Healthcare Foundation

    Lansing, Michigan, 48910

  • Va Southern Nevada Healthcare System

    Las Vegas, Nevada, 89106

  • Utah Cardiology P.C

    Layton, Utah, 84041

  • Lynn N. Smith, Md

    Lewisburg, West Virginia, 24901

  • Central Maine Heart & Vascular Institute

    Lewiston, Maine, 04240

  • New Lexington Clinic, P.S.C.

    Lexington, Kentucky, 40504

  • Mary K. Richards, Md Pa

    Little Rock, Arkansas, 72204

  • South Denver Cardiology Associates Pc

    Littleton, Colorado, 80120

  • Sjh Cardiology Associates

    Liverpool, New York, 13088

  • Advanced Cardiovascular Health Specialists, Pc

    Livonia, Michigan, 48154

  • Dcol Center For Clinical Research

    Longview, Texas, 75605

  • Va Greater Los Angeles Healthcare System

    Los Angeles, California, 90073

  • Va Medical Center

    Louisville, Kentucky, 40202

  • Norton Cardiovascular Associates

    Louisville, Kentucky, 40205

  • St. Mary'S Hospital

    Madison, Wisconsin, 53715

  • St.Mary'S Hospital

    Madison, Wisconsin, 53715

  • Wellstar Cardiovascular Medicine, Pc

    Marietta, Georgia, 30060

  • Cardiology Center, Llc

    Marrero, Louisiana, 70072

  • Loyola University Medical Center

    Maywood, Illinois, 60153

  • North Dallas Research Associates

    McKinney, Texas, 75069

  • Rogue Valley Physicians - Clinical Research Group

    Medford, Oregon, 97504

  • Melbourne Internal Medicine Associates

    Melbourne, Florida, 32901

  • Miami International Cardiology Consultants

    Miami, Florida, 33137-3732

  • Miami International Cardiology Consultants

    Miami, Florida, 33137

  • Dali, Sammi

    Michigan City, Indiana, 46360

  • Aurora Health Care

    Milwaukee, Wisconsin, 53215

  • Medical College Of Wisconsin

    Milwaukee, Wisconsin, 53226

  • Long Island Heart Associates

    Mineola, New York, 11501

  • Minneapolis Va Medical Center

    Minneapolis, Minnesota, 55417

  • University Of Minnesota

    Minneapolis, Minnesota, 55455

  • Coastal Cardiology

    Mission Viejo, California, 92691

  • Mobile Heart Specialists, Pc

    Mobile, Alabama, 36608

  • Clara V. Massey, Md

    Mobile, Alabama, 36617

  • Jack C. Va Medical Center

    Muskogee, Oklahoma, 74401

  • Physicians Regional Medical Group

    Naples, Florida, 34119

  • Charles River Medical Associates

    Natick, Massachusetts, 01760

  • Alfieri Cardiology

    Newark, Delaware, 19713

  • Sentara York Clinical Research

    Norfolk, Virginia, 23510

  • Illinois Heart & Lung Research Center, Sc

    Normal, Illinois, 61761

  • Cpt. James A Lovell Federal Health Care Center

    North Chicago, Illinois, 60064

  • The William W. Backus Hospital

    Norwich, Connecticut, 06360

  • William W Backus Hospital

    Norwich, Connecticut, 06360

  • Kenneth W. Carr Md

    Oceanside, California, 92056

  • Cor Clinical Research, Llc

    Oklahoma City, Oklahoma, 73103

  • University Of Oklahoma Health Sciences Center

    Oklahoma City, Oklahoma, 73104

  • Plaza Medical Group, Pc

    Oklahoma City, Oklahoma, 73112

  • Oklahoma Heart Hospital Physicians

    Oklahoma City, Oklahoma, 73120

  • South Oklahoma Heart Research

    Oklahoma City, Oklahoma, 73135

  • Eminence Research, Llc

    Oklahoma City, Oklahoma, 73139

  • Olive Branch Family Medical Center

    Olive Branch, Mississippi, 38654

  • Palmetto Nephrology Pa

    Orangeburg, South Carolina, 29118

  • Florida Heart Group

    Orlando, Florida, 32803

  • Midwest Cardiology Associates , P.C.

    Overland Park, Kansas, 66209

  • Alpha Medical Research

    Oviedo, Florida, 32765

  • Owensboro Heart & Vascular

    Owensboro, Kentucky, 42303

  • Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group

    Palm Springs, California, 92262

  • Cardiology Consultants

    Pensacola, Florida, 32501

  • Michigan Heart And Vascular Specialists

    Petoskey, Michigan, 49770

  • Internal Medicine Physicians Associates, P.C.

    Phoenix, Arizona, 85006

  • Avera Medical Associates Clinic

    Pierre, South Dakota, 57501

  • Pinehurst Medical Center, Inc

    Pinehurst, North Carolina, 28374

  • Legacy Heart Center

    Plano, Texas, 75024

  • North Texas Medical Research

    Plano, Texas, 75093

  • Princeton Medical Institute

    Princeton, New Jersey, 08540

  • Rhode Island Hospital

    Providence, Rhode Island, 02903

  • Desert Cardiology Consultants Medical Group, Inc

    Rancho Mirage, California, 92270

  • Clinical Associates Research

    Reisterstown, Maryland, 21136

  • Medical Research Initiatives

    Richmond, Virginia, 23220

  • Roanoke Heart Institute, Plc

    Roanoke, Virginia, 24014

  • North Memorial Health Care

    Robbinsdale, Minnesota, 55422

  • William Beaumont Hospital

    Royal Oak, Michigan, 48073

  • Regional Cardiolody Associates

    Sacramento, California, 95819

  • Northern California Research

    Sacramento, California, 95821

  • Sacramento Heart And Vascular Medical Associates

    Sacramento, California, 95825

  • Bhs Specialty Network, Inc

    San Antonio, Texas, 78217

  • Covenant Clinical Research, Pa

    San Antonio, Texas, 78229

  • Star Clinical Trails

    San Antonio, Texas, 78229

  • Arrhythmia Consultants Of The Central Coast Medical Group

    Santa Barbara, California, 93105

  • Northern California Medical Associates

    Santa Rosa, California, 95403

  • Niranjan Seshadri, Md

    Sarasota, Florida, 34232

  • Heart & Vascular Center Research, Inc.

    Sarasota, Florida, 34239

  • Saratoga Cardiology Associates, Pc

    Saratoga Springs, New York, 12866

  • Guthrie Clinic Ltd.

    Sayre, Pennsylvania, 18840

  • Guthrie Medical Group, P.C.

    Sayre, Pennsylvania, 18840

  • Edward Balli, Md, Pa

    Seguin, Texas, 78155

  • Cardio Assoc Of Del Val, P.A.

    Sewell, New Jersey, 08080

  • Cardiology Associates

    Shreveport, Louisiana, 71105

  • Louisiana Heart Center

    Slidell, Louisiana, 70458

  • Medical Research Inst, Inc

    Slidell, Louisiana, 70458

  • Medical Research Institute, Inc

    Slidell, Louisiana, 70458

  • Cardiology Associates, Inc.

    South Bend, Indiana, 46601

  • Central New Jersey Cardiology

    South Plainfield, New Jersey, 07080

  • S. Carolina Pharmaceutical Research

    Spartanburg, South Carolina, 29303

  • Rockwood Clinic Research Cent.

    Spokane, Washington, 99202

  • The Heart And Vascular Institute Of Florida

    St. Petersburg, Florida, 33709

  • Stamford Therapeutics Consortium

    Stamford, Connecticut, 06905

  • Toledo Cardiology Consultants

    Toledo, Ohio, 43608

  • Northwest Heart Center

    Tomball, Texas, 77375

  • Southwest Heart

    Tucson, Arizona, 85710

  • Southern Arizona Va Health Care System

    Tucson, Arizona, 85723

  • Pima Research Foundation

    Tucson, Arizona, 85745

  • Tennessee Center For Clinical Trials

    Tullahoma, Tennessee, 37388

  • Castlerock Clinical Research Consultants, Llc

    Tulsa, Oklahoma, 74136

  • Tupelo Neurology Clinic, Pa

    Tupelo, Mississippi, 38801

  • Tyler Cardiovascular Consultants

    Tyler, Texas, 75701

  • The Univ. Of Texas Health Science Ctr. At Tyler

    Tyler, Texas, 75708

  • University Of Texas Health Science Center At Tyler

    Tyler, Texas, 75708

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania, 15401

  • Ventura Cardio. Cond. Med. Group, Inc.

    Ventura, Louisiana, 93003

  • Research, Inc.

    Vero Beach, Florida, 32960

  • Cardiovascular Associates

    Virginia Beach, Virginia, 23454

  • Progressive Clinical Research

    Vista, California, 92083

  • Family Practice Center Of Wadsworth, Inc.

    Wadsworth, Ohio, 44281

  • Walla Walla Clinic

    Walla Walla, Washington, 99362

  • Cardivasclular Consultants Medical Group

    Walnut Creek, California, 94598

  • George Washington University Medical Faculty Associates

    Washington D.C., District of Columbia, 20037

  • Washington Va Medical Center

    Washington D.C., District of Columbia, 20422

  • Chase Medical Research, Llc

    Waterbury, Connecticut, 06708

  • Cardiology Assc. Of Waukesha

    Waukesha, Wisconsin, 53188

  • West Chester Cardiology, Pc

    West Chester, Pennsylvania, 19380

  • Midatlantic Cardiovascular Associates, Pa

    Westminster, Maryland, 21157

  • Shiva Heart Center Medical Group

    Wildomar, California, 92595

  • Office Of Dr. Kozinn

    Williamsville, New York, 14221

  • Suburban Cardiology

    Williamsville, New York, 14221

  • Cardiology Consultants Of Philadelphia

    Yardley, Pennsylvania, 19067

  • Michigan Heart, P.C.

    Ypsilanti, Michigan, 48197

Other trials in United States

Brazil74 sites

  • Local Institution

    Belém, Pará, 66087-660

  • Local Institution

    Belém, Pará, 66087

  • Local Institution

    Belo Horzonte, Minas Gerais, 30150-221

  • Local Institution

    Belo Horzonte, Minas Gerais, 30150

  • Local Institution

    Blumenau, Santa Catarina, 89010-500

  • Local Institution

    Blumenau, Santa Catarina, 89010

  • Local Institution

    Botucatu, São Paulo, 18618-000

  • Local Institution

    Botucatu, São Paulo, 18618

  • Local Institution

    Campina Grande do Sul, Paraná, 83430-000

  • Local Institution

    Campina Grande do Sul, Paraná, 83430

  • Local Institution

    Campinas, São Paulo, 13059-740

  • Local Institution

    Campinas, São Paulo, 13059

  • Local Institution

    Curitiba, Paraná, 80010-030

  • Local Institution

    Curitiba, Paraná, 80010

  • Local Institution

    Curitiba, Paraná, 80730-150

  • Local Institution

    Curitiba, Paraná, 80730

  • Local Institution

    Juiz de Fora, Minas Gerais, 36021-630

  • Local Institution

    Juiz de Fora, Minas Gerais, 36021

  • Local Institution

    Londrina, Paraná, 86010-450

  • Local Institution

    Londrina, Paraná, 86010

  • Local Institution

    Marília, São Paulo, 17515-000

  • Local Institution

    Marília, São Paulo, 17515-460

  • Local Institution

    Marília, São Paulo, 17515

  • Local Institution

    Marília, São Paulo, 17519-000

  • Local Institution

    Marília, São Paulo, 17519

  • Local Institution

    Natal, Rio Grande do Norte, 59020-100

  • Local Institution

    Natal, Rio Grande do Norte, 59020

  • Local Institution

    Porte Alegre, Rio Grande do Sul, 90610-000

  • Local Institution

    Porte Alegre, Rio Grande do Sul, 90610

  • Local Institution

    Porte Alegre, Rio Grande do Sul, 90880-480

  • Local Institution

    Porte Alegre, Rio Grande do Sul, 90880480

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90020-090

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90020

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90035-903

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90035

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90620-001

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 90620

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 91350-280

  • Local Institution

    Porto Alegre, Rio Grande do Sul, 91350

  • Local Institution

    Rio de Janeiro, 20551-030

  • Local Institution

    Rio de Janeiro, 20551

  • Local Institution

    Rio de Janeiro, 22251-030

  • Local Institution

    Rio de Janeiro, 22251

  • Local Institution

    Salvador, Estado de Bahia, 40144-900

  • Local Institution

    Salvador, Estado de Bahia, 40144

  • Local Institution

    Salvador, Estado de Bahia, 41810-010

  • Local Institution

    Salvador, Estado de Bahia, 41810

  • Local Institution

    San Jose Do Rio Preto, São Paulo, 15090-000

  • Local Institution

    San Jose Do Rio Preto, São Paulo, 15090

  • Local Institution

    Santo André, São Paulo, 09190-610

  • Local Institution

    Santo André, São Paulo, 09190

  • Local Institution

    São José, Santa Catarina, 88103-450

  • Local Institution

    São José, Santa Catarina, 88103

  • Local Institution

    São José do Rio Preto, São Paulo, 15015-210

  • Local Institution

    São José do Rio Preto, São Paulo, 15015-750

  • Local Institution

    São José do Rio Preto, São Paulo, 15015

  • Local Institution

    São Paulo, 01221-900

  • Local Institution

    São Paulo, 01221

  • Local Institution

    São Paulo, 01322-001

  • Local Institution

    São Paulo, 01322

  • Local Institution

    São Paulo, 01323-001

  • Local Institution

    São Paulo, 01323-010

  • Local Institution

    São Paulo, 01323

  • Local Institution

    São Paulo, 04012-180

  • Local Institution

    São Paulo, 04012

  • Local Institution

    São Paulo, 04024-002

  • Local Institution

    São Paulo, 04024

  • Local Institution

    São Paulo, 04038-031

  • Local Institution

    São Paulo, 04038

  • Local Institution

    São Paulo, 08270-070

  • Local Institution

    São Paulo, 08270

  • Local Institution

    Uberaba, Minas Gerais, 38056 055

  • Local Institution

    Uberlândia, Minas Gerais, 38400-299

  • Local Institution

    Uberlândia, Minas Gerais, 38400

Other trials in Brazil

Russia62 sites

  • Local Institution

    Chelyabinsk, 454136

  • Local Institution

    Chita, 672090

  • Local Institution

    Dzerzhinskiy, 140091

  • Local Institution

    Kazan', 420012

  • Local Institution

    Kemerovo, 650002

  • Local Institution

    Kirovsk, 187342

  • Local Institution

    Krasnodar, 350042

  • Local Institution

    Moscow, 105229

  • Local Institution

    Moscow, 109240

  • Local Institution

    Moscow, 111020

  • Local Institution

    Moscow, 111539

  • Local Institution

    Moscow, 115093

  • Local Institution

    Moscow, 115487

  • Local Institution

    Moscow, 117556

  • Local Institution

    Moscow, 117593

  • Local Institution

    Moscow, 119048

  • Local Institution

    Moscow, 119121

  • Local Institution

    Moscow, 119992

  • Local Institution

    Moscow, 121356

  • Local Institution

    Moscow, 121552

  • Local Institution

    Moscow, 123182

  • Local Institution

    Moscow, 125206

  • Local Institution

    Moscow, 125284

  • Local Institution

    Moscow, 125367

  • Local Institution

    Moscow, 125424

  • Local Institution

    Moscow, 127018

  • Local Institution

    Moscow, 129090

  • Local Institution

    Nizhny Novgorod, 603003

  • Local Institution

    Nizhny Novgorod, 603005

  • Local Institution

    Novosibirsk, 630008

  • Local Institution

    Novosibirsk, 630054

  • Local Institution

    Odintsovo, 143000

  • Local Institution

    Penza, 440026

  • Local Institution

    Perm, 614097

  • Local Institution

    Rostov-on-Don, 344022

  • Local Institution

    Ryazan, 390026

  • Local Institution

    Saint Petersburg, 190103

  • Local Institution

    Saint Petersburg, 191025

  • Local Institution

    Saint Petersburg, 192288

  • Local Institution

    Saint Petersburg, 193144

  • Local Institution

    Saint Petersburg, 193163

  • Local Institution

    Saint Petersburg, 193312

  • Local Institution

    Saint Petersburg, 194354

  • Local Institution

    Saint Petersburg, 195271

  • Local Institution

    Saint Petersburg, 196601

  • Local Institution

    Saint Petersburg, 197110

  • Local Institution

    Saint Petersburg, 197341

  • Local Institution

    Saint Petersburg, 198013

  • Local Institution

    Saint Petersburg, 199106

  • Local Institution

    Samara, 443070

  • Local Institution

    Saratov, 410002

  • Local Institution

    Tomsk, 634012

  • Local Institution

    Tver', 170036

  • Local Institution

    Tyumen, 625023

  • Local Institution

    Voronezh, 394065

  • Local Institution

    Voronezh, 394066

  • Local Institution

    Yaroslavl, 150002

  • Local Institution

    Yaroslavl, 150003

  • Local Institution

    Yaroslavl, 150030

  • Local Institution

    Zheleznodorozhniy, 143920

  • Local Institution

    Zhukovsky, 140160

  • Local Institution

    Zhukovsky, 140180

Other trials in Russia

Canada59 sites

  • Local Institution

    Bathurst, New Brunswick, E2A 4X7

  • Local Institution

    Brampton, Ontario, L6Z 4N5

  • Local Institution

    Burlington, Ontario, L7M 4Y1

  • Local Institution

    Burnaby, British Columbia, V5G 1T4

  • Local Institution

    Calgary, Alberta, T2E 7C5

  • Local Institution

    Cambridge, Ontario, N1R 6V6

  • Local Institution

    Cambridge, Ontario, N1R 7R1

  • Local Institution

    Charlottetown, Prince Edward Island, C1A 5Y9

  • Local Institution

    Drummondville, Quebec, J2B 7T1

  • Local Institution

    Edmonton, Alberta, T56-3NJ

  • Local Institution

    Edmonton, Alberta, T5X 3N5

  • Local Institution

    Edmonton, Alberta, T6G 2B7

  • Local Institution

    Edmonton, Alberta, TSA 4L8

  • Local Institution

    Greater Sudbury, Ontario, P3C 5K7

  • Local Institution

    Greater Sudbury, Ontario, P3C5K7

  • Local Institution

    Greater Sudbury, Ontario, P3E 2N8

  • Local Institution

    Greater Sudbury, Ontario, P3E 3B8

  • Local Institution

    Greenfield Park, Quebec, J4V 2G8

  • Local Institution

    Hamilton, Ontario, L8L 2X2

  • Local Institution

    Lachine, Quebec, H8S 2E4

  • Local Institution

    Lévis, Quebec, G6V 4Z5

  • Local Institution

    London, Ontario, N6G 2V2

  • Local Institution

    Longueuil, Quebec, J4K 1C8

  • Local Institution

    Longueuil, Quebec, J4N 0C9

  • Local Institution

    Longueuil, Quebec, J4N 1C2

  • Local Institution

    Mississauga, Ontario, L5B 4A2

  • Local Institution

    Montreal, Quebec, H1T 1C8

  • Local Institution

    Montreal, Quebec, H2W 1T8

  • Local Institution

    Montreal, Quebec, H3A 1A1

  • Local Institution

    Montreal, Quebec, H3T 1E2

  • Local Institution

    Montreal, Quebec, W3R-153

  • Local Institution

    Mount Pearl, Newfoundland and Labrador, A1N 1W7

  • Local Institution

    Nanaimo, British Columbia, V9R 3G9

  • Local Institution

    New Westminster, British Columbia, V3L 3W4

  • Local Institution

    Newmarket, Ontario, L3Y 5G8

  • Local Institution

    Newmarket, Ontario, L3Y 8C3

  • Local Institution

    Niagara Falls, Ontario, L2E 7H1

  • Local Institution

    Niagara Falls, Ontario, L2E7H1

  • Local Institution

    North Bay, Ontario, P1B 2H3

  • Local Institution

    North Vancouver, British Columbia, V7N 4M2

  • Local Institution

    Oshawa, Ontario, L1J 2J9

  • Local Institution

    Oshawa, Ontario, L1J 2K1

  • Local Institution

    Ottawa, Ontario, K1Y 4E9

  • Local Institution

    Ottawa, Ontario, K1Y 4W7

  • Local Institution

    Pointe-Claire, Quebec, H9R 3J1

  • Local Institution

    Québec, Quebec, G1J 1Z6

  • Local Institution

    Saint-Lambert, Quebec, J4P 2H4

  • Local Institution

    Sarnia, Ontario, N7T 4X3

  • Local Institution

    Saskatoon, Saskatchewan, S7L OY7

  • Local Institution

    Scarborough Village, Ontario, M1B 5N1

  • Local Institution

    St. John's, Newfoundland and Labrador, A1A 3R5

  • Local Institution

    St. John's, Newfoundland and Labrador, A1B 3V6

  • Local Institution

    St. John's, Newfoundland and Labrador, A1E 2C2

  • Local Institution

    Ste-Foy, Quebec, G1W 4R4

  • Local Institution

    Toronto, Ontario, M5B 1W8

  • Local Institution

    Toronto, Ontario, M9W 4L6

  • Local Institution

    Victoria, British Columbia, V8R 4R2

  • Local Institution

    Weston, Ontario, M9N 1W4

  • Local Institution

    Winnipeg, Manitoba, R2V 4W3

Other trials in Canada

Argentina49 sites

  • Local Institution

    Adrogué, Buenos Aires, 1846

  • Local Institution

    Bahía Blanca, Buenos Aires, B8000FTD

  • Local Institution

    Buenos Aires, 1119

  • Local Institution

    Buenos Aires, 1181

  • Local Institution

    Buenos Aires, 1280

  • Local Institution

    Buenos Aires, C1280AEB

  • Local Institution

    Buenos Aires, C1426ANZ

  • Local Institution

    Cipolletti, Río Negro Province, 8324

  • Local Institution

    Ciudad Autonoma, Buenos Aires, 1128AAD

  • Local Institution

    Ciudad Autonoma, Buenos Aires, 1128

  • Local Institution

    Ciudad Autonoma, Buenos Aires, 1426 EGR

  • Local Institution

    Ciudad Autonoma, Buenos Aires, C1426 EGR

  • Local Institution

    Ciudad Autonoma, Buenos Aires, CP1425A WC

  • Local Institution

    Ciudad Autonoma, Buenos Aires, CP1425AWC

  • Local Institution

    Ciudad Autonoma de, Buenos Aires, 1180

  • Local Institution

    Ciudad Autonoma de Buenos Aire, Buenos Aires, CI094AAD

  • Local Institution

    Córdoba, Córdoba Province, 5000

  • Local Institution

    Córdoba, 5000

  • Local Institution

    Córdoba, X5000EPU

  • Local Institution

    Córdoba, X5003DCE

  • Local Institution

    Córdoba, X5008KKF

  • Local Institution

    Coronel Suárez, Buenos Aires, B7540GHD

  • Local Institution

    Haedo, Buenos Aires, B1706AJU

  • Local Institution

    Junín, Buenos Aires, 6000

  • Local Institution

    La Plata, Buenos Aires, 1900

  • Local Institution

    La Plata, Buenos Aires, 1902

  • Local Institution

    La Plata, Buenos Aires, B1900AXI

  • Local Institution

    Mar del Plata, Buenos Aires, 7600

  • Local Institution

    Merlo, Buenos Aires, 1722

  • Local Institution

    Merlo, Buenos Aires, B1722COV

  • Local Institution

    Olivos, Buenos Aires, 1602

  • Local Institution

    Quilmes, Buenos Aires, 1878

  • Local Institution

    Ramos Mejía, Buenos Aires, 1706

  • Local Institution

    Ramos Mejía, Buenos Aires, B1704ESN

  • Local Institution

    Ramos Mejía, Buenos Aires, B1704ETD

  • Local Institution

    Rosario, Santa Fe Province, 2000

  • Local Institution

    Rosario, Santa Fe Province, S2000 CVD

  • Local Institution

    Rosario, Santa Fe Province, S2000CVB

  • Local Institution

    Rosario, Santa Fe Province, S2000CVD

  • Local Institution

    Rosario, Santa Fe Province, S2001ODA

  • Local Institution

    Salta, 4400

  • Local Institution

    San Justo, Buenos Aires, 1754

  • Local Institution

    San Martín, Buenos Aires, 1650

  • Local Institution

    San Miguel de Tucumán, T4000NIL

  • Local Institution

    San Miquel de Tucuman, Tucumán Province, 4000

  • Local Institution

    San Nicolás de los Arroyos, Buenos Aires, 2900

  • Local Institution

    Santa Fe, 3000

  • Local Institution

    Zárate, Buenos Aires, 2800

  • Local Institution

    Zárate, Buenos Aires, B2800DGH

Other trials in Argentina

Japan47 sites

  • Local Institution

    Asahikawa-Shi, Hokkaido, 0788214

  • Local Institution

    Fukui, 9100067

  • Local Institution

    Isehara, Kanagawa, 2591193

  • Local Institution

    Itoshima, Fukuoka, 819-1104

  • Local Institution

    Iwakuni, Yamaguchi, 7400021

  • Local Institution

    Izumi, Kagoshima-ken, 8990131

  • Local Institution

    Izumi, Osaka, 594-0071

  • Local Institution

    Kagoshima, 8920822

  • Local Institution

    Kasukabe-shi, Saitama, 3440035

  • Local Institution

    Kasukabe-Shi, Saitama, 344-0035

  • Local Institution

    Katou-gun, Hokkaido, 080111

  • Local Institution

    Katou-Gun, Hokkaido, 0800111

  • Local Institution

    Kobe, Hyōgo, 6540026

  • Local Institution

    Kurume, Fukuoka, 8390863

  • Local Institution

    Kyoto, 6168152

  • Local Institution

    Meguro-ku, Tokyo, 1538515

  • Local Institution

    Meguro-Ku, Tokyo, 153-8515

  • Local Institution

    Nagasaki, 852-8102

  • Local Institution

    Nara, Nara, 630-8305

  • Local Institution

    Ohkawa-City, Fukuoka, 8310016

  • Local Institution

    Ōita, 8700033

  • Local Institution

    Osaka, Osaka, 5330022

  • Local Institution

    Osaka, Osaka, 540-0006

  • Local Institution

    Osaka, Osaka, 5400006

  • Local Institution

    Osaka, 551-0032

  • Local Institution

    Osaka, 5510032

  • Local Institution

    Osaka, 558-8558

  • Local Institution

    Saga, Saga-ken, 840-8571

  • Local Institution

    Saga, Saga-ken, 849-8501

  • Local Institution

    Saga, 8490917

  • Local Institution

    Sapporo, Hokkaido, 0028043

  • Local Institution

    Sendai, Miyagi, 983-8520

  • Local Institution

    Shinagawa-Ku, Tokyo, 1428666

  • Local Institution

    Shirakawa, Fukushima, 961-0005

  • Local Institution

    Suita, Osaka, 5658565

  • Local Institution

    tabashi City, Tokyo, 173-0015

  • Local Institution

    tabashi City, Tokyo, 1730015

  • Local Institution

    Takasaki, Gunma, 3700829

  • Local Institution

    Takatsuki, Osaka, 5690852

  • Local Institution

    Tomakomai-shi, Hokkaido, 0028043

  • Local Institution

    Tomakomai-Shi, Hokkaido, 002-8043

  • Local Institution

    Toyama, Toyama, 9308550

  • Local Institution

    Yao, Osaka, 5810036

  • Local Institution

    Yokohama, Kanagawa, 2278501

  • Local Institution

    Yokohama, Kanagawa, 2458575

  • Local Institution

    Yokosuka, Kanagawa, 2388567

  • Local Institution

    Yūbari, Hokkaido, 0680402

Other trials in Japan

Germany43 sites

  • Local Institution

    Aachen, 52074

  • Local Institution

    Bad Krozingen, 79189

  • Local Institution

    Bad Neustadt/ Salle, 97616

  • Local Institution

    Bad Oeynhausen, 32545

  • Local Institution

    Berlin, 10787

  • Local Institution

    Berlin, 10789

  • Local Institution

    Berlin, 12043

  • Local Institution

    Berlin, 13353

  • Local Institution

    Berlin, 14050

  • Local Institution

    Betzdorf, 57518

  • Local Institution

    Bochum, 44789

  • Local Institution

    Bochum, 44791

  • Local Institution

    Bonn, 53127

  • Local Institution

    Coburg, 96450

  • Local Institution

    Dillingen, 66763

  • Local Institution

    Dresden, 01099

  • Local Institution

    Duisburg, 47139

  • Local Institution

    Essen, 45122

  • Local Institution

    Frankfurt am Main, 60594

  • Local Institution

    Göttingen, 37075

  • Local Institution

    Halle, 06120

  • Local Institution

    Hanover, 30625

  • Local Institution

    Heidelberg, 69115

  • Local Institution

    Heidelberg, 69120

  • Local Institution

    Kassel, 34121

  • Local Institution

    Köpenick, 12559

  • Local Institution

    Lahr, 77933

  • Local Institution

    Ludwigshafen, 67063

  • Local Institution

    Ludwigshafen, 67073

  • Local Institution

    Mannheim, 68167

  • Local Institution

    Marburg, 35043

  • Local Institution

    München, 80636

  • Local Institution

    München, 81545

  • Local Institution

    München, 81675

  • Local Institution

    Osnabrück, 49076

  • Local Institution

    Regensburg, 93053

  • Local Institution

    Riesa, D-01587

  • Local Institution

    Rostiock, 18057

  • Local Institution

    Trier, 54292

  • Local Institution

    Waren, 17192

  • Local Institution

    Witten, 58455

  • Local Institution

    Wolmirstedt, 39326

  • Local Institution

    Worms, 67550

Other trials in Germany

United Kingdom43 sites

  • Local Institution

    Aberdeen, Aberdeenshire, AB25 2ZN

  • Local Institution

    Antrim, BT41 2RL

  • Local Institution

    Barnet, Hertfordshire, EN5 3DJ

  • Local Institution

    Barnsley, South Yorkshire, S75 2EP

  • Local Institution

    Belfast, Antrim, BT14 6AB

  • Local Institution

    Birmingham, WEST Midlands, B18 7QH

  • Local Institution

    Blackpool, FY3 8NR

  • Local Institution

    Bournemouth, Dorset, BH7 7DW

  • Local Institution

    Bury St Edmunds, Suffolk, IP30 9QU

  • Local Institution

    Bury St Edmunds, Suffolk, IP31 2HD

  • Local Institution

    Bury St Edmunds, Suffolk, IP33 2QZ

  • Local Institution

    Cambridge, Cambridgeshire, CB2 2QQ

  • Local Institution

    Cardiff, MID Glamorgan, CF14 4XW

  • Local Institution

    Chesterfield, Derbyshire, S40 4TF

  • Local Institution

    Chesterfield, Derbyshire, S44 5BL

  • Local Institution

    Chichester, EAST Sussex, PO19 6SE

  • Local Institution

    Colchester, Essex, C03 4LN

  • Local Institution

    Craigavon, Armagh, BT63 5QQ

  • Local Institution

    Denmark Hill, Greater London, SE5 9RS

  • Local Institution

    Doncaster, South Yorkshire, DN2 5LT

  • Local Institution

    Glasgow, Aberdeenshire, G11 6NT

  • Local Institution

    Glasgow, Dumbartonshire, G11 6NT

  • Local Institution

    Glasgow, Strathclyde, G51 4TF

  • Local Institution

    Glasgow, G21 3UW

  • Local Institution

    Harrow, Middlesex, HA1 3UJ

  • Local Institution

    Ipswich, Suffolk, IP14 2PU

  • Local Institution

    Ipswich, Suffolk, IP7 5DN

  • Local Institution

    Livingston, WEST Lothian, EH54 6PP

  • Local Institution

    Llandough, MID Glamorgan, CF64 2XX

  • Local Institution

    London, Greater London, SW17 0RE

  • Local Institution

    Newcastle upon Tyne, TYNE and WEAR, NE1 4LP

  • Local Institution

    Newport, Gwent, NP20 2UB

  • Local Institution

    Nottingham, Nottinghamshire, NG5 1PB

  • Local Institution

    Paisley, Renfrewshire, PA2 9PN

  • Local Institution

    Peterborough, Cambridgeshire, PE2 5GP

  • Local Institution

    Romford, Essex, RH7 0AG

  • Local Institution

    Stirling, Stirlingshire, FK8 2AU

  • Local Institution

    Swansea, WEST Glamorgan, SA6 6NL

  • Local Institution

    Westbury, Wiltshire, BA 13 3JD

  • Local Institution

    Westbury, Wiltshire, BA13 3JD

  • Local Institution

    Worksop, Nottinghamshire, S81 OBD

  • Local Institution

    York, Yorkshire, YO31 8HE

  • Local Institution

    York, Yorkshire, YO31 HE

Other trials in United Kingdom

India39 sites

  • Local Institution

    Ahmedabad, Gujarat, 380060

  • Local Institution

    Ahmedabad, 380014

  • Local Institution

    Annāmalainagar, 608002

  • Local Institution

    Bangalore, Karnataka, 5600034

  • Local Institution

    Bangalore, Karnataka, 560054

  • Local Institution

    Bangalore, Karnataka, 560094

  • Local Institution

    Bangalore, 560052

  • Local Institution

    Bikaner, Rajasthan, 334001

  • Local Institution

    Bikaner, Rajasthan, 334003

  • Local Institution

    Calicut, Kerala, 673 004

  • Local Institution

    Chennai, 600006

  • Local Institution

    Hyderabad, Andhra Pradesh, 500004

  • Local Institution

    Hyderabad, 500001

  • Local Institution

    Hyderabad, 500044

  • Local Institution

    Indore, 452001

  • Local Institution

    Indore, 452014

  • Local Institution

    Jalandhar, Punjab, 144008

  • Local Institution

    Kolkata, 700054

  • Local Institution

    Kottayam, 686016

  • Local Institution

    Lucknow, Uttar Pradesh, 226003

  • Local Institution

    Lucknow, 226003

  • Local Institution

    Mumbai Naka, 422005

  • Local Institution

    Mysore, Karnataka, 570004

  • Local Institution

    Nagpur, Maharashtra, 440010

  • Local Institution

    Nagpur, Maharashtra, 440012

  • Local Institution

    Nashik, 422002

  • Local Institution

    New Delhi, 110025

  • Local Institution

    New Delhi, 110060

  • Local Institution

    New Delhi, 116025

  • Local Institution

    Pune, Maharashta, 411011

  • Local Institution

    Pune, Maharashtra, 411001

  • Local Institution

    Pune, Maharashtra, 421006

  • Local Institution

    Pune, 411001

  • Local Institution

    Pune, 411004

  • Local Institution

    Thrissur, 680002

  • Local Institution

    Vadodara, Gujarat, 390007

  • Local Institution

    Vijayawada, 520008

  • Local Institution

    Visakhapatnam, Andhra Pradesh, 530003

  • Local Institution

    Visakhapatnam, Andhrapradesh, 530002

Other trials in India

China37 sites

  • Local Institution

    Beijing, Beijing Municipality, 100001

  • Local Institution

    Beijing, Beijing Municipality, 100020

  • Local Institution

    Beijing, Beijing Municipality, 100050

  • Local Institution

    Beijing, Beijing Municipality, 100088

  • Local Institution

    Beijing, Beijing Municipality, 100101

  • Local Institution

    Beijing, Beijing Municipality, 100853

  • Local Institution

    Changsha, Hunan, 410000

  • Local Institution

    Chengdu, Sichuan, 610041

  • Local Institution

    Chongqing, Sichuan, 400010

  • Local Institution

    Dalian, Liaoning, 116011

  • Local Institution

    Dalian, Liaoning, 116021

  • Local Institution

    Dalian, Liaoning, 116027

  • Local Institution

    Daqing, Heilongjiang, 163001

  • Local Institution

    Guangzhou, Guangdong, 510080

  • Local Institution

    Guangzhou, Guangdong, 510120

  • Local Institution

    Haerbin, Heilongjiang, 150001

  • Local Institution

    Haerbin, Heilongjiang, 150086

  • Local Institution

    Hangzhou, Jiangsu, 310009

  • Local Institution

    Hangzhou, Zhejiang, 310009

  • Local Institution

    Jinan, Shandong, 250012

  • Local Institution

    Jinan, Shandong, 250033

  • Local Institution

    Lanzhou, Gansu, 730000

  • Local Institution

    Lanzhou, Gansu, 730030

  • Local Institution

    Nanjing, Jiangsu, 210029

  • Local Institution

    Qingdao, Shandong, 266011

  • Local Institution

    Shanghai, Shanghai Municipality, 100037

  • Local Institution

    Shanghai, Shanghai Municipality, 200003

  • Local Institution

    Shanghai, Shanghai Municipality, 200011

  • Local Institution

    Shanghai, Shanghai Municipality, 200025

  • Local Institution

    Shanghai, Shanghai Municipality, 200031

  • Local Institution

    Shanghai, Shanghai Municipality, 200080

  • Local Institution

    Shanghai, Shanghai Municipality, 200233

  • Local Institution

    Shanghai, Shanghai Municipality, 200433

  • Local Institution

    Shenyang, Liaoning, 110003

  • Local Institution

    Shenyang, Liaoning, 110016

  • Local Institution

    Shijiazhuang, Hebei, 050000

  • Local Institution

    Wuhan, Hubei, 430060

Other trials in China

Ukraine36 sites

  • Local Institution

    Chernivtsy, 58013

  • Local Institution

    Dnipropetrovsk, 49006

  • Local Institution

    Dnipropetrovsk, 49060

  • Local Institution

    Donetsk, 83003

  • Local Institution

    Donetsk, 83045

  • Local Institution

    Donetsk, 83114

  • Local Institution

    Ivano-Frankivsk, 76025

  • Local Institution

    Kharkiv, 61002

  • Local Institution

    Kharkiv, 61018

  • Local Institution

    Kharkiv, 61039

  • Local Institution

    Kharkiv, 61115

  • Local Institution

    Kharkiv, 61178

  • Local Institution

    Kiev, 01032

  • Local Institution

    Kyiv, 01023

  • Local Institution

    Kyiv, 01103

  • Local Institution

    Kyiv, 02091

  • Local Institution

    Kyiv, 02660

  • Local Institution

    Kyiv, 03049

  • Local Institution

    Kyiv, 03115

  • Local Institution

    Kyiv, 03680

  • Local Institution

    Kyiv, 04050

  • Local Institution

    Kyiv, 04107

  • Local Institution

    Luhansk, 91011

  • Local Institution

    Luhansk, 91016

  • Local Institution

    Lutsk, 43024

  • Local Institution

    Lviv, 79013

  • Local Institution

    Lviv, 79015

  • Local Institution

    Mykolayiv, 54003

  • Local Institution

    Odesa, 65009

  • Local Institution

    Odesa, 65025

  • Local Institution

    Odesa, 65039

  • Local Institution

    Odesa, 65114

  • Local Institution

    Uzhhorod, 88000

  • Local Institution

    Vinnitsa, 21029

  • Local Institution

    Zaporizhzhya, 69035

  • Local Institution

    Zhytomyr, 10002

Other trials in Ukraine

Poland27 sites

  • Local Institution

    Gdynia, 81-423

  • Local Institution

    Gdynia, 81-472

  • Local Institution

    Gdynia, 81-519

  • Local Institution

    Grodzisk Mazowiecki, 05-825

  • Local Institution

    Inowrocław, 88-100

  • Local Institution

    Kielce, 25-736

  • Local Institution

    Kielce, 25-763

  • Local Institution

    Krakow, 30-092

  • Local Institution

    Krakow, 31-135

  • Local Institution

    Krakow, 31-202

  • Local Institution

    Lodz, 91-347

  • Local Institution

    Lodz, 91347

  • Local Institution

    Piotrkow Trybunalski, 97-300

  • Local Institution

    Płock, 09-400

  • Local Institution

    Płock, 09-402

  • Local Institution

    Płońsk, 09-100

  • Local Institution

    Poznan, 60-531

  • Local Institution

    Poznan, 60479

  • Local Institution

    Ruda Śląska, 41-703

  • Local Institution

    Skierniewice, 96-100

  • Local Institution

    Słupsk, 76-200

  • Local Institution

    Torun, 87100

  • Local Institution

    Warsaw, 01-138

  • Local Institution

    Warsaw, 04-073

  • Local Institution

    Warsaw, 04-628

  • Local Institution

    Warsaw, 04-749

  • Local Institution

    Węgrów, 07100

Other trials in Poland

Australia21 sites

  • Local Institution

    Adelaide, South Australia, SA 5000

  • Local Institution

    Ashford, South Australia, 5035

  • Local Institution

    Auchenflower, Queensland, 4066

  • Local Institution

    Bedford Park, South Australia, 5042

  • Local Institution

    Box Hill, Victoria, 3128

  • Local Institution

    Brisbane, Queensland, 4032

  • Local Institution

    Caboolture, Queensland, 4510

  • Local Institution

    Coffs Harbour, New South Wales, 2450

  • Local Institution

    Concord, New South Wales, 2139

  • Local Institution

    Dandenong, Victoria, 3175

  • Local Institution

    Fremantle, Western Australia, 6160

  • Local Institution

    Geelong, Victoria, 3220

  • Local Institution

    Gosford, New South Wales, 2250

  • Local Institution

    Herston, Queensland, 4029

  • Local Institution

    Joondalup, Western Australia, 6027

  • Local Institution

    Kippa-Ring, Queensland, 4021

  • Local Institution

    Kogarah, New South Wales, 2217

  • Local Institution

    Miranda, New South Wales, 2228

  • Local Institution

    Nambour, Queensland, 4560

  • Local Institution

    Sherwood, Queensland, 4075

  • Local Institution

    Woodville, South Australia, 5011

Other trials in Australia

Belgium19 sites

  • Local Institution

    Aalst, 9300

  • Local Institution

    Antwerp, 2020

  • Local Institution

    Antwerp, 2060

  • Local Institution

    Arlon, 6700

  • Local Institution

    Bruges, 8000

  • Local Institution

    Brussels, 1090

  • Local Institution

    Dillingen, 66763

  • Local Institution

    Genk, 3600

  • Local Institution

    Ghent, 9000

  • Local Institution

    Gilly, 6060

  • Local Institution

    Hasselt, 3500

  • Local Institution

    Huy, 4500

  • Local Institution

    Kortrijk, 8500

  • Local Institution

    Menen, 8930

  • Local Institution

    Mol, 2400

  • Local Institution

    Montegnée, 4420

  • Local Institution

    Verviers, 4800

  • Local Institution

    Woluwe-Saint-Lambert, 1200

  • Local Institution

    Yvoir, 5530

Other trials in Belgium

Hungary19 sites

  • Local Institution

    Budapest, 1023

  • Local Institution

    Budapest, 1032

  • Local Institution

    Budapest, 1085

  • Local Institution

    Budapest, 1096

  • Local Institution

    Budapest, 1125

  • Local Institution

    Debrecen, 4032

  • Local Institution

    Dunaújváros, 2400

  • Local Institution

    Győr, 9023

  • Local Institution

    Gyula, 5700

  • Local Institution

    Hódmezővásárhely, 6800

  • Local Institution

    Komárom, 2921

  • Local Institution

    Mosonmagyaróvár, 9200

  • Local Institution

    Orosháza, 5900

  • Local Institution

    Pécs, 7624

  • Local Institution

    Siófok, 8600

  • Local Institution

    Siófok, 8601

  • Local Institution

    Sopron, 9400

  • Local Institution

    Szentes, 6600

  • Local Institution

    Zalaegerszeg, 8900

Other trials in Hungary

Mexico18 sites

  • Local Institution

    Col. Toriello Guerra, Mexico City, CP 14050

  • Local Institution

    Culiacán, Sinaloa, 80020

  • Local Institution

    Guadalajara, Jalisco, 44200

  • Local Institution

    Guadalajara, Jalisco, 44600

  • Local Institution

    Guadalajara, Jalisco, 44656

  • Local Institution

    Jalapa, Veracruz, 91020

  • Local Institution

    Mexico City, Mexico City, 06070

  • Local Institution

    Mexico City, Mexico City, 06726

  • Local Institution

    Mexico City, Mexico City, 07760

  • Local Institution

    Mexico City, Mexico City, 10700

  • Local Institution

    Mexico City, Mexico City, 14080

  • Local Institution

    Monterrey, Nuevo León, 64000

  • Local Institution

    Monterrey, Nuevo León, 64700

  • Local Institution

    Monterrey, Nuevo León, 64710

  • Local Institution

    Morelia, Michoacán, 58000

  • Local Institution

    Puebla City, 11490

  • Local Institution

    Querétaro, 76000

  • Local Institution

    Tijuana, Estado de Baja California, 22500

Other trials in Mexico

Spain18 sites

  • Local Institution

    Albacete, 02006

  • Local Institution

    Barcelona, 08003

  • Local Institution

    Barcelona, 08035

  • Local Institution

    Elda, 03600

  • Local Institution

    Figueres, 17600

  • Local Institution

    Girona, 17007

  • Local Institution

    La Cañada, Almeria, 04120

  • Local Institution

    Las Palmas, 35010

  • Local Institution

    Lugo, Galicia, 27003

  • Local Institution

    Madrid, 28006

  • Local Institution

    Madrid, 28040

  • Local Institution

    Madrid, 28046

  • Local Institution

    Palma de Mallorca, 07010

  • Local Institution

    San Juan, Alicante, 03550

  • Local Institution

    San Sebastián de los Reyes, 28703

  • Local Institution

    Tarragona, 43007

  • Local Institution

    Torrevieja, Alicante, 03186

  • Local Institution

    Viladecans, 08840

Other trials in Spain

Denmark17 sites

  • Local Institution

    Arhus C, 8000

  • Local Institution

    Copenhagen, 2100

  • Local Institution

    Esbjerg, 6700

  • Local Institution

    Frederiksberg, 2000

  • Local Institution

    Frederikssund, 3600

  • Local Institution

    Gentofte Municipality, 2900

  • Local Institution

    Haderslev, 6100

  • Local Institution

    Hellerup, 2900

  • Local Institution

    Herlev, 2730

  • Local Institution

    Herning, 7400

  • Local Institution

    Hillerød, 3400

  • Local Institution

    Hvidovre, 2650

  • Local Institution

    Kolding, 6000

  • Local Institution

    Odense, 5000

  • Local Institution

    Silkeborg, 8600

  • Local Institution

    Slagelse, 4200

  • Local Institution

    Svendborg, 5700

Other trials in Denmark

Italy17 sites

  • Local Institution

    Ascoli Piceno, 63100

  • Local Institution

    Campobasso, 86100

  • Local Institution

    Chieti, 66013

  • Local Institution

    Cremona, 26100

  • Local Institution

    Fidenza (Pr), 43036

  • Local Institution

    Genova, 16132

  • Local Institution

    Isernia, 86170

  • Local Institution

    Lido di Camaiore, Lucca, 55043

  • Local Institution

    Livorno, 57100

  • Local Institution

    Milan, 20132

  • Local Institution

    Naples, 80131

  • Local Institution

    Palermo, 90127

  • Local Institution

    Reggio Emilia, 42100

  • Local Institution

    Roma, 00168

  • Local Institution

    San Daniele de Friuli, 33038

  • Local Institution

    Torino, 10153

  • Local Institution

    Vittorio Veneto (Tv), 31029

Other trials in Italy

Israel15 sites

  • Local Institution

    Afula, 18101

  • Local Institution

    Ashkelon, 78306

  • Local Institution

    Giv‘atayim, 53583

  • Local Institution

    Hadera, 38100

  • Local Institution

    Haifa, 31096

  • Local Institution

    Haifa, 34362

  • Local Institution

    Holon, 58100

  • Local Institution

    Jerusalem, 91120

  • Local Institution

    Jerusalem, 91240

  • Local Institution

    Kfar Saba, 44281

  • Local Institution

    Nazareth, 16000

  • Local Institution

    Nazareth, 16100

  • Local Institution

    Petah Tikva, 49100

  • Local Institution

    Safed, 13100

  • Local Institution

    Tel Aviv, 64239

Other trials in Israel

Romania15 sites

  • Local Institution

    Baia Mare, 430031

  • Local Institution

    Bucharest, 011192

  • Local Institution

    Bucharest, 020125

  • Local Institution

    Bucharest, 021659

  • Local Institution

    Bucharest, 030572

  • Local Institution

    Bucharest, 050098

  • Local Institution

    Cluj-Napoca, 400001

  • Local Institution

    Cluj-Napoca, 400347

  • Local Institution

    Iași, 700503

  • Local Institution

    Oradea, 410169

  • Local Institution

    Sibiu, 550245

  • Local Institution

    Târgu Mureş, 540103

  • Local Institution

    Târgu Mureş, 540136

  • Local Institution

    Timișoara, 300024

  • Local Institution

    Timișoara, 300320

Other trials in Romania

South Korea15 sites

  • Local Institution

    Anyang-si, Gyeonggi-do, 431-070

  • Local Institution

    Busan, 602-702

  • Local Institution

    Daegu, 700-712

  • Local Institution

    Daegu, 705-717

  • Local Institution

    Daejeon, 302-718

  • Local Institution

    Goyang, 411-706

  • Local Institution

    Gwangju, 501-757

  • Local Institution

    Gyeonggi-do, 463-707

  • Local Institution

    Incheon, Korea, 400-711

  • Local Institution

    Pusan, 602-739

  • Local Institution

    Scongnam-Si, 463-712

  • Local Institution

    Seoul, 110-744

  • Local Institution

    Seoul, 130-709

  • Local Institution

    Seoul, 143-729

  • Local Institution

    Suwon, 443-721

Other trials in South Korea

Netherlands14 sites

  • Local Institution

    's-Hertogenbosch, 5211 NL

  • Local Institution

    Breda, 4818 CK

  • Local Institution

    Deventer, 7416 SE

  • Local Institution

    Eindhoven, 5623 EJ

  • Local Institution

    Eindhoven, 5623EJ

  • Local Institution

    Enschede, 7513 ER

  • Local Institution

    Hardenberg, 7772 SE

  • Local Institution

    Hilversum, 1213 XZ

  • Local Institution

    Nijmegen, 6525 GA

  • Local Institution

    Oss, 5342 BT

  • Local Institution

    Rotterdam, 3045 PM

  • Local Institution

    Tiel, 4002 WP

  • Local Institution

    Utrecht, 3582 KE

  • Local Institution

    Velp, 6883 AZ

Other trials in Netherlands

Sweden14 sites

  • Local Institution

    Goteberg, 413 45

  • Local Institution

    Helsingborg, 251 87

  • Local Institution

    Linköping, 581 85

  • Local Institution

    Lund, 222 21

  • Local Institution

    Örebro, 701 85

  • Local Institution

    Örebro, 70185

  • Local Institution

    Skellefteå, 931 86

  • Local Institution

    Stockholm, 111 35

  • Local Institution

    Stockholm, 111 57

  • Local Institution

    Stockholm, 118 83

  • Local Institution

    Stockholm, 141 86

  • Local Institution

    Stockholm, 171 76

  • Local Institution

    Uppsala, 751 85

  • Local Institution

    Vaxjo, 351 85

Other trials in Sweden

Czechia12 sites

  • Local Institution

    Boskovice, 680 21

  • Local Institution

    Brno, 625 00

  • Local Institution

    Brno-Malomerice, 614 00

  • Local Institution

    Ivančice, 664 91

  • Local Institution

    Kladno, 272 59

  • Local Institution

    Litomyšl, 570 14

  • Local Institution

    Městec Králové, 289 03

  • Local Institution

    Ostrava, 70852

  • Local Institution

    Prague, 128 08

  • Local Institution

    Prague, 158 00

  • Local Institution

    Příbram, 261 01

  • Local Institution

    Ústí nad Orlicí, 562 18

Other trials in Czechia

Norway12 sites

  • Local Institution

    Ålesund, 6003

  • Local Institution

    Bergen, 5021

  • Local Institution

    Bergen, N-5021

  • Local Institution

    Elverum, 2408

  • Local Institution

    Flekkefjord, 4400

  • Local Institution

    Nesttun, 5221

  • Local Institution

    Oslo, 0407

  • Local Institution

    Skien, 3710

  • Local Institution

    Stavanger, 4064

  • Local Institution

    Straume, 5353

  • Local Institution

    Tønsberg, 3116

  • Local Institution

    Tromsø, 9038

Other trials in Norway

Peru11 sites

  • Local Institution

    Bellavista, Provincia Constitucional del Callao, 2176

  • Local Institution

    Bellavista, Provincia Constitucional del Callao, CALLAO 2

  • Local Institution

    Chiclayo, Lambayeque, CIX

  • Local Institution

    Jesus Maria, Lima region, 11

  • Local Institution

    Jesus Maria, Lima region, LIMA 11

  • Local Institution

    Lima, LIMA 01

  • Local Institution

    Lima, LIMA 1

  • Local Institution

    Lima, LIMA 33

  • Local Institution

    Miraflores, Lima region, LIMA 18

  • Local Institution

    San Borja, Lima region, LIMA 41

  • Local Institution

    San Martín de Porres, Lima region, LIMA 31

Other trials in Peru

South Africa10 sites

  • Local Institution

    Bellville Cape Town, Western Cape, 7530

  • Local Institution

    George, Western Cape, 6529

  • Local Institution

    Observatory, CAPE TOWN, 7925

  • Local Institution

    Parow, Western Cape, 7505

  • Local Institution

    Pretoria, Gauteng, 0084

  • Local Institution

    Pretoria, Gauteng, 0132

  • Local Institution

    Richards Bay, KwaZulu-Natal, 3900

  • Local Institution

    Somerset West, Western Cape, 7130

  • Local Institution

    Westdene, Bloemfontein, 9301

  • Local Institution

    Worcester, Western Cape, 6850

Other trials in South Africa

Chile9 sites

  • Local Institution

    Osorno, Los Lagos Region, 5311089

  • Local Institution

    Osorno, Los Lagos Region, 5311523

  • Local Institution

    Santiago, Santiago Metropolitan, 7500520

  • Local Institution

    Santiago, Santiago Metropolitan, 7500922

  • Local Institution

    Santiago, Santiago Metropolitan, 8330074

  • Local Institution

    Temuco, Araucania, 4781156

  • Local Institution

    Temuco, Araucania, 4781176

  • Local Institution

    Temuco, Valparaiso, 4781173

  • Local Institution

    Viña del Mar, Valparaiso, 2570017

Other trials in Chile

Finland8 sites

  • Local Institution

    Helsinki, 00280

  • Local Institution

    Helsinki, FI-00280

  • Local Institution

    Hus, 00029

  • Local Institution

    Jyväskylä, 40100

  • Local Institution

    Kemi, 94100

  • Local Institution

    Oulu, 90100

  • Local Institution

    Pori, 28120

  • Local Institution

    Tampere, 33100

Other trials in Finland

Philippines8 sites

  • Local Institution

    Laoag, Ilocos Norte, 2900

  • Local Institution

    Manila, 1000

  • Local Institution

    Manila, 1008

  • Local Institution

    Naga, 4400

  • Local Institution

    Pasig, 1600

  • Local Institution

    Quezon, 1100

  • Local Institution

    Quezon City, 1102

  • Local Institution

    San Juan City, 1100

Other trials in Philippines

Colombia7 sites

  • Local Institution

    Barranquilla, XXXXX

  • Local Institution

    Barranquilla

  • Local Institution

    Bogotá, 000

  • Local Institution

    Bogotá

  • Local Institution

    Cali

  • Local Institution

    Medellín, Antioquia

  • Local Institution

    Medellín

Other trials in Colombia

France7 sites

  • Local Institution

    Amiens, 80054

  • Local Institution

    Bordeaux, 33075

  • Local Institution

    Brest, 29609

  • Local Institution

    Grenoble, 38043

  • Local Institution

    La Seyne-sur-Mer, 83500

  • Local Institution

    Paris, 75018

  • Local Institution

    Six-Fours-les-Plages, 83140

Other trials in France

Taiwan6 sites

  • Local Institution

    Taipei, 100

  • Local Institution

    Taipei, 10449

  • Local Institution

    Taipei, 104

  • Local Institution

    Taipei, 111

  • Local Institution

    Taipei, 112

  • Local Institution

    Taipei, 220

Other trials in Taiwan

Malaysia5 sites

  • Local Institution

    Batu Caves, Selangor, 68100

  • Local Institution

    Kota Samarahan, Sarawak, 94300

  • Local Institution

    Kuala Lumpur, 56000

  • Local Institution

    Kuala Lumpur, 59100

  • Local Institution

    Kubang Kerian, Kelantan, 16150

Other trials in Malaysia

Austria3 sites

  • Local Institution

    Graz, 8036

  • Local Institution

    Oberpullendorf, 7350

  • Local Institution

    Vienna, 1160

Other trials in Austria

Puerto Rico3 sites

  • Local Institution

    Cayey, 00736

  • Local Institution

    Cidra, 00739

  • Local Institution

    Ponce, 00717

Other trials in Puerto Rico

Turkey (Türkiye)3 sites

  • Local Institution

    Ankara, 06100

  • Local Institution

    Eskişehir, 26480

  • Local Institution

    Izmir, 35100

Other trials in Turkey (Türkiye)

Hong Kong2 sites

  • Local Institution

    Hong Kong

  • Local Institution

    Shatin

Other trials in Hong Kong

Switzerland2 sites

  • Local Institution

    Baden, 5404

  • Local Institution

    Bern, 3010

Other trials in Switzerland

Singapore1 site

  • Local Institution

    Singapore, 168752

Other trials in Singapore

About this study

Official title: A Phase 3, Active (Warfarin) Controlled, Randomized, Double-Blind, Parallel Arm Study to Evaluate Efficacy and Safety of Apixaban in Preventing Stroke and Systemic Embolism in Subjects With Nonvalvular Atrial Fibrillation

The trial seeks to determine if apixaban, an investigational anticoagulant (blood-thinner) is as effective as standard therapy (warfarin) in preventing stroke and systemic embolism in subjects with atrial fibrillation and risk factors for stroke.

Being tested
warfarin, apixaban
Medical subject headings
Atrial Fibrillation, Atrial Flutter

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • warfarinDrug

    Also called Coumadin, BMS-565793

    Oral tablets, 2.0 mg, adjusted to an INR of 2.5 (range 2.0 to 3.0)

  • apixabanDrug

    Also called BMS-562247

    Oral tablets, 5.0 mg or 2.5 mg, twice daily

Study groups in NCT00412984
Study groupRoleWhat they receive
1Active comparatorNot described
Receives: Drug: warfarin
2ExperimentalNot described
Receives: Drug: apixaban

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period

    All suspected efficacy events were adjudicated by the Central Events Committee (CEC). Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.

    Measured: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).

  2. Rate of Adjudicated Stroke or Systemic Embolism (SE) During the Intended Treatment Period

    Rate=Number of adjudicated stroke or SE events per 100 patient years. Diagnosis of stroke=the nontraumatic focal neurological deficit lasting at least 24 hours, and includes ischemic stroke, hemorrhagic stroke, ischemic stroke with hemorrhagic conversion, stroke of uncertain type, and retinal ischemic event (embolism, infarction). Diagnosis of SE=clinical history consistent with an acute loss of blood flow to a peripheral artery (or arteries), supported by evidence of embolism from surgical specimens, autopsy, angiography, vascular imaging, or other objective testing.

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

Secondary outcomes (12)

  1. Number of Participants With Event of Major (International Society on Thrombosis and Hemostasis [ISTH]) Bleeding During Treatment Period

    ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more, and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following critical sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

  2. Rate of Adjudicated Major (ISTH) Bleed Events During Treatment Period

    Rate=number of adjudicated major (ISTH) bleed events per 100 patient years. ISTH Bleeding Criteria: Major bleeding=a bleeding event that was: clinically overt bleeding accompanied by a decrease in hemoglobin (Hgb) of 2 g/dL or more and/or a transfusion of 2 or more units of packed red blood cells; bleeding that occurred in at least 1 of the following sites: intracranial, intraspinal, intraocular (within the corpus of the eye; a conjunctival bleed is not an intraocular bleed), pericardial, intra-articular, intramuscular with compartment syndrome, and retroperitoneal; bleeding that was fatal.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

  3. Number of Participants With Events of All-Cause Death During the Intended Treatment Period

    Death was defined as all-cause mortality. All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, myocardial infarction (MI), sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  4. Rate of Adjudicated All-Cause Death During the Intended Treatment Period

    All unobserved deaths were assumed to be cardiovascular in nature unless a non-cardiovascular cause could be clearly provided. Cardiovascular=deaths due to ischemic and hemorrhagic stroke, SE, MI, sudden death, heart failure, other cardiovascular, and unobserved deaths. Non-cardiovascular=all deaths due to a clearly documented non-cardiovascular cause (further classified into the categories: bleeding, study drug toxicity other than bleeding, malignancy, infection, trauma, and pulmonary causes of death).

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  5. Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), and Myocardial Infarction (MI) (as Individual Endpoints) During the Intended Treatment Period

    Diagnosis for an acute or evolving MI=elevation of creatine kinase-MB isoenzyme (CK-MB) or Troponin T or I ≥ 2 × the upper limit of normal (ULN), or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1.

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  6. Rate of Ischemic or Unspecified Stroke, Hemorrhagic Stroke, Systemic Embolism (SE), Myocardial Infarction (MI) and All-Cause Death (ACD) (as Composite Endpoints) During the Intended Treatment Period

    Diagnosis for an acute or evolving MI=elevation of CK-MB or Troponin T or I ≥ 2 × the ULN, or if no CK-MB or troponin values are available, a total CK ≥ 2×ULN, or new, significant (≥0.04 s) Q waves in ≥2 contiguous leads. For descriptions of Stroke and SE, see Outcome Measure 1. For description of ACD, see Outcome Measure 5.

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  7. Number of Warfarin/Vitamin K Antagonist (VKA) Naive Participants With Composite Stroke / Systemic Embolism (SE) / Major Bleeding During the Intended Treatment Period

    For descriptions of Stroke and SE, see Outcome Measure 1. For description of Major bleeding, see Outcome Measure 3.

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  8. Rate of Composite Stroke / Systemic Embolism / Major Bleeding in Warfarin/Vitamin K Antagonist (VKA) Naive Participants During the Intended Treatment Period

    Measured: "Intended Treatment Period" started on the day of randomization and ended at the efficacy cut-off date (date on which it was expected that the target number of primary efficacy events [448] would have occurred; set to 30-Jan-2011, prior to unblinding).

  9. Number of Participants With Events of Major or Clinically Relevant Nonmajor (CRNM) Bleed During Treatment Period

    Major bleeding=bleeding that is clinically overt and that either resulted in a decrease in hemoglobin of 2 g/dL or more over a 24-hour period, led to a transfusion of 2 or more units of packed red blood cells, occurred in a critical site, or led to death. CRNM bleeding=bleeding that is clinically overt, that satisfies none of the additional criteria required for the event to be adjudicated as a major bleeding event, that led to either hospital admission for bleeding, physician-guided medical or surgical treatment for bleeding, or a change in antithrombotic therapy.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

  10. Rate of Events of Major or Clinically Relevant Non-Major (CRNM) Bleed During Treatment Period

    Rate=number of major or CRNM bleed events per 100 patient years. Major=clinically overt and either 1) resulted in a decrease in hemoglobin of 2 g/dL or more, or 2) led to a transfusion of 2 or more units of packed red blood cells, or 3) occurred in a critical site, or 4) led to death. CRNM bleeding=clinically overt, but satisfied no additional criteria required to be adjudicated as a major bleeding event, and led to either 1) hospital admission for bleeding or 2) physician guided medical or surgical treatment for bleeding or 3) a change in antithrombotic therapy.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

  11. Number of Participants With All Bleeding Events During Treatment Period

    All bleeding events include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

  12. Rate of All Bleeding Events During Treatment Period

    Rate=number of all bleeding events per 100 patient years. "All bleeding events" include major bleeding, CRNM bleeding (see Outcome Measure 12 Description for definitions), plus events of minor bleeding and fatal bleeding. Minor bleeding: All acute clinically overt bleeding events not meeting the criteria for either major bleeding or clinically relevant non-major bleeding will be classified as minor bleeding. Fatal bleeding is defined as a bleeding event that the Clinical Events Committee determines is the primary cause of death or contributes directly to death.

    Measured: "Treatment Period" started with first dose of blinded study drug and ended 2 days after the last dose of blinded study drug. Mean duration of exposure to double-blind study drug was 1.7 years in each treatment group.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted19 Dec 2006 (estimated)
  2. Study start31 Dec 2006
  3. Primary completion25 May 2011
  4. Study completion25 May 2011

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 3
Primary purpose
Prevention
Allocation
Randomised
Intervention model
Parallel groups
Masking
Double blind
Who is masked
Participant, Investigator
Enrolment
20,976 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00412984
Sponsor's protocol ID
CV185-030
Acronym
ARISTOTLE
Status last verified
May 2018
First submitted
18 Dec 2006
Last updated
3 Jul 2018
Data monitoring committee
Yes

Publications

  • Vinereanu D, Wojdyla DM, Alexander JH, Lopes RD, Al-Khatib SM, Gersh BJ, Bahit MC, Hohnloser SH, Flaker GC, Rosenquist M, Hijazi Z, Wallentin L, Granger CB. Heart rate and death and hospitalization for heart failure in patients with persistent or permanent atrial fibrillation: Insights from the ARISTOTLE trial. Am Heart J. 2023 Nov;265:132-136. doi: 10.1016/j.ahj.2023.07.006. Epub 2023 Jul 26.

    PubMed 37506747

  • Hijazi Z, Lindback J, Oldgren J, Benz AP, Alexander JH, Connolly SJ, Eikelboom JW, Granger CB, Lopes RD, Siegbahn A, Wallentin L. Individual net clinical outcome with oral anticoagulation in atrial fibrillation using the ABC-AF risk scores. Am Heart J. 2023 Jul;261:55-63. doi: 10.1016/j.ahj.2023.03.012. Epub 2023 Mar 27.

    PubMed 36990261

  • Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.

    PubMed 35570249

  • Pol T, Hijazi Z, Lindback J, Oldgren J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Siegbahn A, Wallentin L. Using multimarker screening to identify biomarkers associated with cardiovascular death in patients with atrial fibrillation. Cardiovasc Res. 2022 Jul 20;118(9):2112-2123. doi: 10.1093/cvr/cvab262.

    PubMed 34358298

  • Pol T, Hijazi Z, Lindback J, Alexander JH, Bahit MC, De Caterina R, Eikelboom JW, Ezekowitz MD, Gersh BJ, Granger CB, Hylek EM, Lopes R, Siegbahn A, Wallentin L. Evaluation of the prognostic value of GDF-15, ABC-AF-bleeding score and ABC-AF-death score in patients with atrial fibrillation across different geographical areas. Open Heart. 2021 Mar;8(1):e001471. doi: 10.1136/openhrt-2020-001471.

    PubMed 33741689

  • Hijazi Z, Wallentin L, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Pol T, Yusuf S, Oldgren J, Siegbahn A. Screening of Multiple Biomarkers Associated With Ischemic Stroke in Atrial Fibrillation. J Am Heart Assoc. 2020 Dec 15;9(24):e018984. doi: 10.1161/JAHA.120.018984. Epub 2020 Dec 9.

    PubMed 33292046

  • Wallentin L, Lindback J, Eriksson N, Hijazi Z, Eikelboom JW, Ezekowitz MD, Granger CB, Lopes RD, Yusuf S, Oldgren J, Siegbahn A. Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation. Eur Heart J. 2020 Nov 1;41(41):4037-4046. doi: 10.1093/eurheartj/ehaa697.

    PubMed 32984892

  • Hijazi Z, Granger CB, Hohnloser SH, Westerbergh J, Lindback J, Alexander JH, Keltai M, Parkhomenko A, Lopez-Sendon JL, Lopes RD, Siegbahn A, Wallentin L. Association of Different Estimates of Renal Function With Cardiovascular Mortality and Bleeding in Atrial Fibrillation. J Am Heart Assoc. 2020 Sep 15;9(18):e017155. doi: 10.1161/JAHA.120.017155. Epub 2020 Aug 31.

    PubMed 32865097

  • Zeitouni M, Giczewska A, Alexander JH. Reply: Specifics of Dose Modification in ARISTOTLE. J Am Coll Cardiol. 2020 Jul 7;76(1):128-129. doi: 10.1016/j.jacc.2020.05.013. No abstract available.

    PubMed 32616154

  • Rosjo H, Hijazi Z, Omland T, Westerbergh J, Lyngbakken MN, Alexander JH, Gersh BJ, Granger CB, Hylek EM, Lopes RD, Siegbahn A, Wallentin L. Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial. J Intern Med. 2020 Aug;288(2):248-259. doi: 10.1111/joim.13072. Epub 2020 May 18.

    PubMed 32350915

  • Zeitouni M, Giczewska A, Lopes RD, Wojdyla DM, Christersson C, Siegbahn A, De Caterina R, Steg PG, Granger CB, Wallentin L, Alexander JH; ARISTOTLE Investigators. Clinical and Pharmacological Effects of Apixaban Dose Adjustment in the ARISTOTLE Trial. J Am Coll Cardiol. 2020 Mar 17;75(10):1145-1155. doi: 10.1016/j.jacc.2019.12.060.

    PubMed 32164888

  • Stanifer JW, Pokorney SD, Chertow GM, Hohnloser SH, Wojdyla DM, Garonzik S, Byon W, Hijazi Z, Lopes RD, Alexander JH, Wallentin L, Granger CB. Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Advanced Chronic Kidney Disease. Circulation. 2020 Apr 28;141(17):1384-1392. doi: 10.1161/CIRCULATIONAHA.119.044059. Epub 2020 Mar 12.

    PubMed 32160801

  • Garcia DA, Fisher DA, Mulder H, Wruck L, De Caterina R, Halvorsen S, Granger CB, Held C, Wallentin L, Alexander JH, Lopes RD. Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation (ARISTOTLE) trial. Am Heart J. 2020 Mar;221:1-8. doi: 10.1016/j.ahj.2019.10.013. Epub 2019 Oct 31.

    PubMed 31896036

  • Dalgaard F, Mulder H, Wojdyla DM, Lopes RD, Held C, Alexander JH, De Caterina R, Washam JB, Hylek EM, Garcia DA, Gersh BJ, Wallentin L, Granger CB, Al-Khatib SM. Patients With Atrial Fibrillation Taking Nonsteroidal Anti-Inflammatory Drugs and Oral Anticoagulants in the ARISTOTLE Trial. Circulation. 2020 Jan 7;141(1):10-20. doi: 10.1161/CIRCULATIONAHA.119.041296. Epub 2019 Nov 21.

    PubMed 31747786

  • Goldstein SA, Green J, Huber K, Wojdyla DM, Lopes RD, Alexander JH, Vinereanu D, Wallentin L, Granger CB, Al-Khatib SM. Characteristics and Outcomes of Atrial Fibrillation in Patients With Thyroid Disease (from the ARISTOTLE Trial). Am J Cardiol. 2019 Nov 1;124(9):1406-1412. doi: 10.1016/j.amjcard.2019.07.046. Epub 2019 Aug 7.

    PubMed 31474328

Questions about this trial

What is this clinical trial studying?

A Phase 3 study testing warfarin and apixaban in people with Atrial Fibrillation and Atrial Flutter, run by Bristol-Myers Squibb at 1,111 sites in 41 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 5 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Jul 2018. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1,111 sites in United States, Brazil, Russia, Canada, Argentina and 36 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 3 studies compare the treatment with the current standard treatment or a placebo in a large group, to confirm how well it works and watch for side effects.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

Yes. Results are posted in the registry (first posted 29 Apr 2013). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Number of Participants With First Event of Ischemic/Unspecified Stroke, Hemorrhagic Stroke, or Systemic Embolism (SE) During the Intended Treatment Period (time frame: Time to first event in "Intended Treatment Period": started on day of randomization, ended at efficacy cut-off date (date target number of primary efficacy events [448] was expected to have occurred; set to 30-Jan-2011, prior to unblinding).). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00412984, which also lists 60 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Jul 2018.

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