Healthy VolunteersPhase 1/2R7128NCT00382798
Adaptive Phase I HCV Study With Nucleoside Analogue, in Combination With Interferon and Ribavirin
A Phase 1/2 study testing RO5024048 in people with Healthy Volunteers and Hepatitis C Virus, run by Pharmasset at 9 sites in 3 countries.
Trial summary
This is an adaptive Phase I study to evaluate RO5024048 in the following groups: Healthy Volunteers (Part 1 - Single Ascending Dose Study) -Enrollment completed Hepatitis C virus (HCV) genotype 1 infected patients who have failed interferon therapy (Part 2- Multiple Ascending Dose Study)-Enrollment Completed HCV… Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Healthy Volunteers, Hepatitis C Virus
- What is being tested?
- RO5024048
- How many people
- 75 participants
- Where
- 9 sitesin 3 countries
- Study dates
- Oct 2006to Sep 2008
- Phase
- Phase 1/2
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Males or females of non-childbearing potential aged 18 to 65 years. Females must be surgically sterile, or post-menopausal for at least 12 months. Females of child-bearing potential may be enrolled provided they use two methods of acceptable contraception.
- Diagnosed with chronic liver disease consistent with chronic hepatitis C infection, genotype-1, for at least 6 months.
- Genotype 1 Patients who are HCV treatment-naive, with no history of exposure to interferon, ribavirin, or direct antivirals; OR Genoytpe 2 or 3 patients who have previously been treated with interferon.
- Otherwise healthy as determined at screening.
- At least one measurement of serum HCV RNA of ≥ 100,000 IU/mL measured during Screening by the COBAS AmpliPrep/COBAS TaqMan HCV.
- ALT and AST measurement at Screening < 5 times of ULN.
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- Liver biopsy obtained within 2 years (24 calendar months) prior to Screening with a fibrosis classification of non-cirrhotic as judged by a local pathologist. Incomplete cirrhosis (Ishak 5) is also considered as cirrhosis. If no history of liver biopsy, a study qualifying biopsy must be performed during the screening period, prior to randomization.
- Negative pregnancy test (for all females) at Screening and Day -1.
- All male patients with female partners of child-bearing potential must use two acceptable methods of contraception (one of which must be a barrier method), during and for 3 months after participation in the study.
- A body mass index (BMI) of ≥ 18 kg/m2, but not exceeding 36.
- Able to abstain from any alcohol (including alcohol-containing products) and able to limit caffeine consumption to two 8-ounce cups of coffee or the equivalent per day, from 72 hours before receiving study drug through the end of the study (Day 56 or early termination).
- Able to effectively communicate with the Investigator and other testing center personnel.
- Able to participate and willing to give written informed consent and comply with the study restrictions.
Who cannot join
- Positive test at Screening for HAV, HBV, or HIV.
- History or other evidence of a medical condition associated with chronic liver disease, decompensated liver disease, renal disease, immunologically mediated disease, chronic pulmonary disease, cardiac disease, thyroid disease, severe retinopathy, severe psychiatric disease, organ transplantation, cancer, seizure disorder, or pancreatitis.
- Abnormal hematological, biochemical, or coagulation parameters at Screening; or positive fecal occult blood test.
- Estimated creatinine clearance of 90 mL/minute or less at Screening.
- Poorly controlled hypertension, or anyone who at screening or baseline has a BP of 140/90 or greater.
- Type 1 or 2 diabetics with hemoglobin A1C > 7.
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- A baseline increased risk for anemia.
- Screening ECG QTc value ≥ 450 ms and/or clinically significant ECG findings.
- Positive results for drugs of abuse at Screening.
- History of clinically significant drug allergy to nucleoside/nucleotide analogues.
- Donation or loss of more than 400 mL blood within 2 months prior to anticipated dose administration.
- Participation in a clinical study with an investigational drug, biologic, or device within 3 months prior to anticipated dose administration.
- Males whose female partner is pregnant.
- Any chronic viral (including HSV), bacterial, mycobacterial, fungal, parasitic, or protozoal infection.
- Serum alpha-feto-protein > 50 ng/mL at screening.
- Receipt of any vaccination within 30 days prior to anticipated dose administration.
Trial locations and contacts
9 sites in 3 countries.
9 sites in 3 countries
United States7 sites
University of Colorado Health Sciences Center
Aurora, Colorado, 80045
Duke Clinical Research Institute
Durham, North Carolina, 27710
University of Florida
Gainesville, Florida, 32610
University of Iowa
Iowa City, Iowa, 52242
Orlando Immunology Center
Orlando, Florida, 32803
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104
Quest Clinical Research
San Francisco, California, 94115
About this study
Official title: A Multiple-Center, Observer-Blinded, Randomized, Placebo-Controlled, Single & Multiple Ascending Dose Study to Investigate the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, & Food Effect of RO5024048 in Healthy Volunteers & in Patients With Chronic HCV Infection
This is an adaptive Phase I study to evaluate RO5024048 in the following groups:
- Healthy Volunteers (Part 1 - Single Ascending Dose Study) -Enrollment completed
- Hepatitis C virus (HCV) genotype 1 infected patients who have failed interferon therapy (Part 2- Multiple Ascending Dose Study)-Enrollment Completed
- HCV genotype 1-infected patients who are treatment naive, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)-Currently Enrolling
- HCV genotype 2-3 infected patients who have previously been treated with interferon but who did not respond, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)- Currently enrolling
Read more
The study aims to determine if RO5024048 is safe and well-tolerated in healthy people and in people infected with hepatitis C virus. The amount of RO5024048 in the blood will be measured during the study and the amount of hepatitis C virus in the blood after each dose will also be measured.
During Part 3 of the study, RO5024048 will be given with PEG-IFN and RBV, two drugs currently used and approved for the treatment of HCV.
Read the detailed description
Part 3: During Part 3 of the study, HCV gentoype 1-infected patients who are treatment-naive (have not been treated for HCV) will be enrolled. Up to 75 patients (3 groups of 25) will be dosed for 28 days with RO5024048, PEG-IFN, and RBV. The first dose of RO5024048 to be given in Part 3 will be 500 mg BID, the second dose will be 1500 mg BID, and the third group will be 1000 mg BID. Standard doses of PEG-IFN and RBV will be used during Part 3. Doses of PEG-IFN and RBV will be modified if necessary.
An 4th group of 25 HCV genotype 2 or 3-infected patients who have been previously treated with interferon but who did not respond will also be enrolle in part 3. The dose given to this 4th group will be 1500 mg BID, in combination with standard doses of PEG-IFN and RBV.
Following 28 days of combination dosing with RO5024048, PEG-IFN, and RBV, patients will be dosed an additional 28 days (through Day 56 of the study) with just PEG-IFN, and RBV. After completing 56 days under this study, patients who participate in Part 3 will be optionally enrolled into a standard of care protocol with PEG-IFN and RBV, to be conducted by Roche. Patients who opt to enroll into the standard of care protocol will be given up to 40 weeks of PEG-IFN and RBV.
The primary objective for Part 3 is to assess the safety, tolerability and pharmacokinetics of RO5024048 in treatment-naive HCV Genotype 1-infected patients, and in non-responder HCV Genotype 2/3-infected patients, after once or twice daily dosing in combination wtih PEG-IFN and RBV for 28 days on an outpatient basis. The secondary objective of Part 3 (COMBO) is to evaluate the short-term decrease in viral load in treatment-naive HCV Genotype 1-infected patients, and in non-responder HCV Genotype 2/3-infected patients, after once or twice daily dosing of RO5024048 in combination with PEG-IFN and RBV for 28 days.
Part 1 (closed for enrollment): Single ascending dose study
During Part 1, 5 escalating single oral doses of RO5024048 or placebo were given to 40 healthy volunteers, when fasted (have not eaten any food for at least 10 hours). The doses given were 500 mg, 1500 mg, 4500 mg, 6000 mg, and 9000 mg. Another group of 6 volunteers was given 1500 mg with food.
The primary objective of Part 1 was to assess the safety, tolerability, and pharmacokinetics (amount of drug in the blood) of RO5024048 under fasting conditions. The secondary objective of Part 1 was to explore the effect of food on the pharmacokinetics of RO5024048.
Part 2: (Closed for enrollment) Multiple ascending dose study
During Part 2 of the study, 40 HCV-genotype 1-infected patients were given multiple-ascending oral doses of RO5024048 or placebo for 14 days. The doses given were 750 mg once daily, 1500 mg once daily, 750 mg twice daily, and 1500 mg twice daily.
The primary objective of Part 2 was to assess the safety, tolerability and pharmacokinetics of RO5024048 in HCV Genotype 1-infected patients after daily or twice daily dosing for 14 days. The secondary objective was to evaluate the decrease in viral load in HCV Genotype 1-infected patients after daily or twice daily dosing of RO5024048 for 14 days
- Conditions
- Healthy Volunteers, Hepatitis C Virus
- Being tested
- RO5024048
- Medical subject headings
- Hepatitis C
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
RO5024048Drug
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted2 Oct 2006 (estimated)
- Study startOct 2006
- Primary completionSep 2008
- Study completionSep 2008
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Healthy VolunteersStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 1/2
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 75 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Pharmasset
- Sponsor type
- Industry (pharma, biotech, devices)
- Collaborators
- Hoffmann-La Roche
- Investigators
- M. Michelle Berrey, MD, Study director, Pharmasset
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00382798
- Sponsor's protocol ID
- P7081-5101
- Acronym
- R7128
- Status last verified
- Apr 2009
- First submitted
- 28 Sep 2006
- Last updated
- 27 Apr 2009
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 27 Apr 2009. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- A Multiple-Center, Observer-Blinded, Randomized, Placebo-Controlled, Single & Multiple Ascending Dose Study to Investigate the Pharmacokinetics, Pharmacodynamics, Safety, Tolerability, & Food Effect of RO5024048 in Healthy Volunteers & in Patients With Chronic HCV Infection
- ClinicalTrials.gov ID
- NCT00382798
- Acronym / sponsor ID
- R7128 / P7081-5101
- Conditions
- Healthy Volunteers, Hepatitis C Virus
- Phase
- Phase 1/2
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 75 participants (estimated)
- Lead sponsor
- PharmassetIndustry (pharma, biotech, devices)
- Collaborators
- Hoffmann-La Roche
- Study start
- Oct 2006
- Primary completion
- Sep 2008 (actual)
- Study completion
- Sep 2008 (actual)
- First posted
- 2 Oct 2006 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This is an adaptive Phase I study to evaluate RO5024048 in the following groups:
- Healthy Volunteers (Part 1 - Single Ascending Dose Study) -Enrollment completed
- Hepatitis C virus (HCV) genotype 1 infected patients who have failed interferon therapy (Part 2- Multiple Ascending Dose Study)-Enrollment Completed
- HCV genotype 1-infected patients who are treatment naive, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)-Currently Enrolling
- HCV genotype 2-3 infected patients who have previously been treated with interferon but who did not respond, to be dosed in combination with PEG-IFN and RBV (Part 3 - Combination Dose Study)- Currently enrolling
The study aims to determine if RO5024048 is safe and well-tolerated in healthy people and in people infected with hepatitis C virus. The amount of RO5024048 in the blood will be measured during the study and the amount of hepatitis C virus in the blood after each dose will also be measured.
During Part 3 of the study, RO5024048 will be given with PEG-IFN and RBV, two drugs currently used and approved for the treatment of HCV.
Detailed description
Part 3: During Part 3 of the study, HCV gentoype 1-infected patients who are treatment-naive (have not been treated for HCV) will be enrolled. Up to 75 patients (3 groups of 25) will be dosed for 28 days with RO5024048, PEG-IFN, and RBV. The first dose of RO5024048 to be given in Part 3 will be 500 mg BID, the second dose will be 1500 mg BID, and the third group will be 1000 mg BID. Standard doses of PEG-IFN and RBV will be used during Part 3. Doses of PEG-IFN and RBV will be modified if necessary.
An 4th group of 25 HCV genotype 2 or 3-infected patients who have been previously treated with interferon but who did not respond will also be enrolle in part 3. The dose given to this 4th group will be 1500 mg BID, in combination with standard doses of PEG-IFN and RBV.
Following 28 days of combination dosing with RO5024048, PEG-IFN, and RBV, patients will be dosed an additional 28 days (through Day 56 of the study) with just PEG-IFN, and RBV. After completing 56 days under this study, patients who participate in Part 3 will be optionally enrolled into a standard of care protocol with PEG-IFN and RBV, to be conducted by Roche. Patients who opt to enroll into the standard of care protocol will be given up to 40 weeks of PEG-IFN and RBV.
The primary objective for Part 3 is to assess the safety, tolerability and pharmacokinetics of RO5024048 in treatment-naive HCV Genotype 1-infected patients, and in non-responder HCV Genotype 2/3-infected patients, after once or twice daily dosing in combination wtih PEG-IFN and RBV for 28 days on an outpatient basis. The secondary objective of Part 3 (COMBO) is to evaluate the short-term decrease in viral load in treatment-naive HCV Genotype 1-infected patients, and in non-responder HCV Genotype 2/3-infected patients, after once or twice daily dosing of RO5024048 in combination with PEG-IFN and RBV for 28 days.
Part 1 (closed for enrollment): Single ascending dose study
During Part 1, 5 escalating single oral doses of RO5024048 or placebo were given to 40 healthy volunteers, when fasted (have not eaten any food for at least 10 hours). The doses given were 500 mg, 1500 mg, 4500 mg, 6000 mg, and 9000 mg. Another group of 6 volunteers was given 1500 mg with food.
The primary objective of Part 1 was to assess the safety, tolerability, and pharmacokinetics (amount of drug in the blood) of RO5024048 under fasting conditions. The secondary objective of Part 1 was to explore the effect of food on the pharmacokinetics of RO5024048.
Part 2: (Closed for enrollment) Multiple ascending dose study
During Part 2 of the study, 40 HCV-genotype 1-infected patients were given multiple-ascending oral doses of RO5024048 or placebo for 14 days. The doses given were 750 mg once daily, 1500 mg once daily, 750 mg twice daily, and 1500 mg twice daily.
The primary objective of Part 2 was to assess the safety, tolerability and pharmacokinetics of RO5024048 in HCV Genotype 1-infected patients after daily or twice daily dosing for 14 days. The secondary objective was to evaluate the decrease in viral load in HCV Genotype 1-infected patients after daily or twice daily dosing of RO5024048 for 14 days
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (13 listed)
- Males or females of non-childbearing potential aged 18 to 65 years. Females must be surgically sterile, or post-menopausal for at least 12 months. Females of child-bearing potential may be enrolled provided they use two methods of acceptable contraception.
- Diagnosed with chronic liver disease consistent with chronic hepatitis C infection, genotype-1, for at least 6 months.
- Genotype 1 Patients who are HCV treatment-naive, with no history of exposure to interferon, ribavirin, or direct antivirals; OR Genoytpe 2 or 3 patients who have previously been treated with interferon.
- Otherwise healthy as determined at screening.
- At least one measurement of serum HCV RNA of ≥ 100,000 IU/mL measured during Screening by the COBAS AmpliPrep/COBAS TaqMan HCV.
Key exclusion criteria (16 listed)
- Positive test at Screening for HAV, HBV, or HIV.
- History or other evidence of a medical condition associated with chronic liver disease, decompensated liver disease, renal disease, immunologically mediated disease, chronic pulmonary disease, cardiac disease, thyroid disease, severe retinopathy, severe psychiatric disease, organ transplantation, cancer, seizure disorder, or pancreatitis.
- Abnormal hematological, biochemical, or coagulation parameters at Screening; or positive fecal occult blood test.
- Estimated creatinine clearance of 90 mL/minute or less at Screening.
- Poorly controlled hypertension, or anyone who at screening or baseline has a BP of 140/90 or greater.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| RO5024048 | Drug | – |
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Apr 2009.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
M. Michelle Berrey, MD study director
Pharmasset
9 sites in 3 countries: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 1/2 study testing RO5024048 in people with Healthy Volunteers and Hepatitis C Virus, run by Pharmasset at 9 sites in 3 countries.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 13 inclusion and 16 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Apr 2009. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 9 sites in United States, New Zealand, Puerto Rico. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this combined phase mean?
Phase 1 studies test a treatment in a small group of people for the first time or in a new way, mainly to check safety and find the right dose.
Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Apr 2009.