BL22 Immunotoxin in Treating Patients With Refractory Chronic Lymphocytic Leukemia, Prolymphocytic Leukemia, or Non-Hodgkin's Lymphoma

DISEASE CHARACTERISTICS:

• Diagnosis of B-cell leukemia or lymphoma of 1 of the following types:
• Chronic lymphocytic leukemia
• Failed standard chemotherapy
• Prolymphocytic leukemia
• Failed standard chemotherapy
• Indolent non-Hodgkin's lymphoma, including mantle cell lymphoma
• Stage III or IV disease
• Failed ≥ 1 prior doxorubicin- or fludarabine-containing standard therapy
• CD22-positive disease, as evidenced by 1 of the following:
• More than 15% malignant cells react with anti-CD22 by immunohistochemistry
• More than 30% malignant cells are CD22-positive by fluorescence-activated cell sorting analysis
• More than 400 CD22 sites per malignant cell (average) by radiolabeled anti-CD22 binding
• Treatment is medically indicated, as evidenced by any of the following:
• Progressive disease-related symptoms
• Progressive cytopenias due to marrow involvement
• Progressive or painful splenomegaly or adenopathy
• Rapidly increasing lymphocytosis
• Autoimmune hemolytic anemia or thrombocytopenia
• Increased frequency of infections
• No neutralizing anti-toxin or anti-mouse immunoglobulin G (IgG) antibodies to BL22 or PE38
• No serum neutralization of > 75% of the activity of 1 μg/mL of BL22
• No CNS disease requiring treatment
• No hairy cell leukemia

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• More than 6 months

Hematopoietic

• Absolute neutrophil count > 1,000/mm^3*
• Platelet count > 40,000/mm^3 NOTE: *Patients with leukemia are eligible regardless of absolute neutrophil count; Grade III-IV pancytopenia or growth factor dependence allowed if due to disease

Hepatic

• Bilirubin < 1.5 times upper limit of normal (ULN)
• ALT and AST < 2.5 times ULN

Renal

• Creatinine ≤ 1.5 mg/dL

Pulmonary

• FEV1 ≥ 60% of predicted
• DLCO ≥ 55% of predicted

Other

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• HIV negative

PRIOR CONCURRENT THERAPY:

Biologic therapy

• Prior bone marrow transplantation allowed
• More than 3 weeks since prior biologic therapy, including interferon, denileukin diftitox, or LMB-2 immunotoxin
• More than 3 months since prior monoclonal antibody therapy (e.g., rituximab)

Chemotherapy

• See Disease Characteristics
• More than 3 weeks since prior cytotoxic chemotherapy

Endocrine therapy

• More than 1 week since prior steriods
• Less than 5 doses for non-treatment reasons (e.g., allergy prophylaxis)
• No evidence of disease response

Radiotherapy

• More than 3 weeks since prior whole-body electron beam radiotherapy
• Radiotherapy within the past 3 weeks allowed provided the volume of bone marrow treated is < 10% AND the patient has measurable disease located outside the radiation port

Surgery

• Not specified

Other

• More than 3 weeks since prior retinoids
• More than 3 weeks since other prior systemic therapy for this malignancy