HealthyNCT00077038
Brain Activity in Visual-Motor Behavior
An observational study of Healthy, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
Trial summary
This study will examine how the brain works when people look at an object, follow a moving object with their eyes, and reach out their hand to an object. Different areas of the brain work together in reaching out a hand to an object. Read more about this study
- Who is it for?
- Ages 20 years and olderHealthy volunteers can take part
- Conditions the study is for
- Healthy
- How many people
- 20 participants
- Where
- 1 siteUnited States
- Study dates
- 6 Feb 2004to 31 Mar 2007
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- The subjects must be 20 years old or older and right-handed as screened by Edinburgh handedness inventory.
- They must be healthy and have no known history of neurological or ophthalmological diseases.
Who cannot join
- Subjects under the age of 20 will be excluded from this study.
- Subjects who match the criteria below will be excluded from this study due to human subject protection and because they may negatively affect the MEG data quality.
- Subjects wearing glasses.
- Subjects with involuntary movement or dyskinesia.
- Subjects with spontaneous nystagmus.
- Subjects who can not execute the eye or manual tracking after sufficient practice time.
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- Subjects with metal objects in the body.
- Subjects with history of severe head trauma.
- Pregnant women.
Trial locations and contacts
1 site in 1 country.
United States1 site
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, 20892
About this study
Official title: Modulation of the Visual Information Processing in the Human Parieto-Frontal Network as Studied by a Frequency Tagging Technique During Visuomotor Tracking
This study will examine how the brain works when people look at an object, follow a moving object with their eyes, and reach out their hand to an object. Different areas of the brain work together in reaching out a hand to an object. These areas are also important for concentrating on objects or following them with the eyes. This study will use magnetoencephalography (MEG) to observe more precisely how discrete parts of the brain work during these movements. MEG is a new technique for recording magnetic field changes produced by brain activity.
Healthy normal volunteers 20 years of age and older who are right-handed and who have no history of brain or eye disease may be eligible for this study. Candidates will be screened with a medical history and brief physical examination. They will complete questionnaires for MEG screening and for determining handedness.
Read more
Participants undergo MEG recording and magnetic resonance imaging (MRI). For MEG, the subject sits comfortably in front of a computer screen, and a cone containing magnetic field detectors is lowered onto the head. Electrodes are placed on both sides of the outer part of the eyelids and just above and below the left eye to monitor eye movement. During MEG, subjects perform the following tasks:
- Eye fixation: A small white cross and a white ring appear on the center of the computer screen. Another white ring moves slowly around the screen in random fashion. Subjects keep their eyes fixed on the central cross and concentrate on the ring at the center, ignoring the moving ring.
- Ocular tracking: The same cross and rings in task 1 appear on the screen, but in this task the subjects follow the moving ring with their eyes and ignore the cross and ring in the center.
- Peripheral manual tracking task (right hand): In addition to the cross and rings in task 1, a small white disc-shaped cursor appears on the screen. Using their right hand, subjects use a joystick to move the cursor as precisely as possible to follow the moving ring, while keeping their eyes fixed on the central cross.
- Peripheral manual tracking task (left hand): The same as task 3, except using the left hand.
- Central manual tracking: The cross, rings, and joystick are the same as in task 3. Subjects move the cursor to follow the moving ring as precisely as possible, while following the moving ring with their eyes and ignoring the cross and ring in the center of the screen.
Subjects practice each task before MEG recording starts. Then they perform each task twice in random order, with a 1- or 2-minute break between tasks.
Subjects who do not have previous MRI images filed in NINDS's database undergo MRI scanning. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The scanner is a metal cylinder surrounded by a strong magnetic field. Subjects lie still on a table that can slide in an out of the cylinder. They can communicate with the MRI staff at all times during the procedure.
Read the detailed description
HYPOTHESIS:
The hypothesis of this study is that the parieto-frontal network is activated by visuomotor behavior in humans.
OBJECTIVES:
To detect frontal and parietal cortical activity during a visuomotor task with frequency modulated visual stimuli using magnetoencephalography (MEG).
To reveal how the parieto-frontal activities change according to different conditions of attention, gaze, and motor output.
STUDY POPULATION:
Right handed normal volunteers with no known history of neurological or ophthalmological diseases will be recruited to participate in this study.
DESIGN:
This study is a combination of a frequency tagging method and an MEG. Visual stimuli are presented, flickering in specific (tagged) frequencies. The cortical distribution of the visual information is estimated from the tagged frequency response of the MEG signal. We will use a visuomotor tracking task with a multifactorial task design (attention, target motion, position in retinal coordinate, and manual tracking) to evaluate the effect of each factor separately.
OUTCOME MEASURES:
We will use the adaptive linear-filter technique known as synthetic aperture magnetometry (SAM) to estimate the source location and strength of the tagged frequencies. The estimated cortical source activity power at the frontal and parietal cortices will be group analyzed with multiple logistic models and by analysis of variance (ANOVA) with correction for multiple comparisons.
- Conditions
- Healthy
- Keywords
- Visual Feedback, Cortical Connectivity, Magnetoencephalography, Eye Tracking, Healthy Volunteer, HV
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted10 Feb 2004 (estimated)
- Study start6 Feb 2004
- Study completion31 Mar 2007
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for HealthyStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Enrolment
- 20 participants
Sponsor and investigators
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00077038
- Sponsor's protocol ID
- 040117
- Other IDs
- 04-N-0117
- Status last verified
- 31 Mar 2007
- First submitted
- 9 Feb 2004
- Last updated
- 2 Jul 2017
- Results posted
- No
Publications
Glover S. Optic ataxia as a deficit specific to the on-line control of actions. Neurosci Biobehav Rev. 2003 Aug;27(5):447-56. doi: 10.1016/s0149-7634(03)00072-1.
PubMed 14505686
Study at a glance
From the registry record, last updated by the sponsor on 2 Jul 2017. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Modulation of the Visual Information Processing in the Human Parieto-Frontal Network as Studied by a Frequency Tagging Technique During Visuomotor Tracking
- ClinicalTrials.gov ID
- NCT00077038
- Acronym / sponsor ID
- 040117
- Conditions
- Healthy
- Keywords
- Visual Feedback, Cortical Connectivity, Magnetoencephalography, Eye Tracking, Healthy Volunteer, HV
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 20 participants
- Lead sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)US National Institutes of Health
- Study start
- 6 Feb 2004
- Study completion
- 31 Mar 2007
- First posted
- 10 Feb 2004 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will examine how the brain works when people look at an object, follow a moving object with their eyes, and reach out their hand to an object. Different areas of the brain work together in reaching out a hand to an object. These areas are also important for concentrating on objects or following them with the eyes. This study will use magnetoencephalography (MEG) to observe more precisely how discrete parts of the brain work during these movements. MEG is a new technique for recording magnetic field changes produced by brain activity.
Healthy normal volunteers 20 years of age and older who are right-handed and who have no history of brain or eye disease may be eligible for this study. Candidates will be screened with a medical history and brief physical examination. They will complete questionnaires for MEG screening and for determining handedness.
Participants undergo MEG recording and magnetic resonance imaging (MRI). For MEG, the subject sits comfortably in front of a computer screen, and a cone containing magnetic field detectors is lowered onto the head. Electrodes are placed on both sides of the outer part of the eyelids and just above and below the left eye to monitor eye movement. During MEG, subjects perform the following tasks:
- Eye fixation: A small white cross and a white ring appear on the center of the computer screen. Another white ring moves slowly around the screen in random fashion. Subjects keep their eyes fixed on the central cross and concentrate on the ring at the center, ignoring the moving ring.
- Ocular tracking: The same cross and rings in task 1 appear on the screen, but in this task the subjects follow the moving ring with their eyes and ignore the cross and ring in the center.
- Peripheral manual tracking task (right hand): In addition to the cross and rings in task 1, a small white disc-shaped cursor appears on the screen. Using their right hand, subjects use a joystick to move the cursor as precisely as possible to follow the moving ring, while keeping their eyes fixed on the central cross.
- Peripheral manual tracking task (left hand): The same as task 3, except using the left hand.
- Central manual tracking: The cross, rings, and joystick are the same as in task 3. Subjects move the cursor to follow the moving ring as precisely as possible, while following the moving ring with their eyes and ignoring the cross and ring in the center of the screen.
Subjects practice each task before MEG recording starts. Then they perform each task twice in random order, with a 1- or 2-minute break between tasks.
Subjects who do not have previous MRI images filed in NINDS's database undergo MRI scanning. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. The scanner is a metal cylinder surrounded by a strong magnetic field. Subjects lie still on a table that can slide in an out of the cylinder. They can communicate with the MRI staff at all times during the procedure.
Detailed description
HYPOTHESIS:
The hypothesis of this study is that the parieto-frontal network is activated by visuomotor behavior in humans.
OBJECTIVES:
To detect frontal and parietal cortical activity during a visuomotor task with frequency modulated visual stimuli using magnetoencephalography (MEG).
To reveal how the parieto-frontal activities change according to different conditions of attention, gaze, and motor output.
STUDY POPULATION:
Right handed normal volunteers with no known history of neurological or ophthalmological diseases will be recruited to participate in this study.
DESIGN:
This study is a combination of a frequency tagging method and an MEG. Visual stimuli are presented, flickering in specific (tagged) frequencies. The cortical distribution of the visual information is estimated from the tagged frequency response of the MEG signal. We will use a visuomotor tracking task with a multifactorial task design (attention, target motion, position in retinal coordinate, and manual tracking) to evaluate the effect of each factor separately.
OUTCOME MEASURES:
We will use the adaptive linear-filter technique known as synthetic aperture magnetometry (SAM) to estimate the source location and strength of the tagged frequencies. The estimated cortical source activity power at the frontal and parietal cortices will be group analyzed with multiple logistic models and by analysis of variance (ANOVA) with correction for multiple comparisons.
Study design
Who may qualify
- Ages
- 20 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (2 listed)
- The subjects must be 20 years old or older and right-handed as screened by Edinburgh handedness inventory.
- They must be healthy and have no known history of neurological or ophthalmological diseases.
Key exclusion criteria (9 listed)
- Subjects under the age of 20 will be excluded from this study.
- Subjects who match the criteria below will be excluded from this study due to human subject protection and because they may negatively affect the MEG data quality.
- Subjects wearing glasses.
- Subjects with involuntary movement or dyskinesia.
- Subjects with spontaneous nystagmus.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Jul 2017.
- Background: PubMed 14505686Glover S. Optic ataxia as a deficit specific to the on-line control of actions. Neurosci Biobehav Rev. 2003 Aug;27(5):447-56. doi: 10.1016/s0149-7634(03)00072-1.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Healthy, run by National Institute of Neurological Disorders and Stroke (NINDS) at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Jul 2017. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00077038, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Jul 2017.