Cardiovascular DiseasesNCT00005266
Cardiovascular Disease Mortality in The NAS-NRC Twin Registry
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
Trial summary
To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions. Read more about this study
- Who is it for?
- Ages Up to 100 years, men only
- Conditions the study is for
- Cardiovascular Diseases, Heart Diseases, Hypertension
- How many people
- Not given
- Where
- No sites listed yet
- Study dates
- Sep 1990to Sep 1992
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 100 years
- Men only
- No healthy volunteers
- Child, Adult, Older adult
No eligibility criteria
About this study
To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions.
Read the detailed description
BACKGROUND:
Methodologically, statistical methods in genetics and epidemiology have developed largely independently; and as a result, there seemed to be little communication between the two fields. Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable, multiple and continuous environmental risk factors, and correlation in outcomes between related individuals.
The study was supported by the Small Grants Program established by the National Heart, Lung, and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies.
DESIGN NARRATIVE:
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. The contributions of genetic and environmental factors to twin similarities in health behavior were also examined.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Diabetes Mellitus, Obesity, Coronary Disease
- Medical subject headings
- Cardiovascular Diseases, Heart Diseases, Hypertension, Diabetes Mellitus, Obesity, Coronary Disease, Myocardial Ischemia
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2000 (estimated)
- Study startSep 1990
- Study completionSep 1992
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (8)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- More trials run by National Heart, Lung, and Blood Institute (NHLBI)The sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
Sponsor and investigators
- Sponsor type
- US National Institutes of Health
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00005266
- Sponsor's protocol ID
- 1150
- Other IDs
- R03HL046115
- Status last verified
- May 2000
- First submitted
- 25 May 2000
- Last updated
- 16 Mar 2016
- Results posted
- No
Publications
Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327(12):829-33. doi: 10.1056/NEJM199209173271201.
PubMed 1508241Carmelli D, Swan GE, Cardon LR. Genetic mediation in the relationship of education to cognitive function in older people. Psychol Aging. 1995 Mar;10(1):48-53. doi: 10.1037//0882-7974.10.1.48.
PubMed 7779316Swan GE, Carmelli D. Characteristics associated with excessive weight gain after smoking cessation in men. Am J Public Health. 1995 Jan;85(1):73-7. doi: 10.2105/ajph.85.1.73.
PubMed 7832265Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet. 1994 Sep;55(3):566-73.
PubMed 8079995Carmelli D, Selby JV, Quiroga J, Reed T, Fabsitz RR, Christian JC. 16-year incidence of ischemic heart disease in the NHLBI twin study. A classification of subjects into high- and low-risk groups. Ann Epidemiol. 1994 May;4(3):198-204. doi: 10.1016/1047-2797(94)90097-3.
PubMed 8055120Carmelli D, Robinette D, Fabsitz R. Concordance, discordance and prevalence of hypertension in World War II male veteran twins. J Hypertens. 1994 Mar;12(3):323-8.
PubMed 8021487Carmelli D, Swan GE, Robinette D. The relationship between quitting smoking and changes in drinking in World War II veteran twins. J Subst Abuse. 1993;5(2):103-16. doi: 10.1016/0899-3289(93)90055-g.
PubMed 8400834Carmelli D, Heath AC, Robinette D. Genetic analysis of drinking behavior in World War II veteran twins. Genet Epidemiol. 1993;10(3):201-13. doi: 10.1002/gepi.1370100306.
PubMed 8349101
Study at a glance
From the registry record, last updated by the sponsor on 16 Mar 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Cardiovascular Disease Mortality in The NAS-NRC Twin Registry
- ClinicalTrials.gov ID
- NCT00005266
- Acronym / sponsor ID
- 1150
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Diabetes Mellitus, Obesity, Coronary Disease
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- National Heart, Lung, and Blood Institute (NHLBI)US National Institutes of Health
- Study start
- Sep 1990
- Study completion
- Sep 1992 (actual)
- First posted
- 26 May 2000 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To analyze cardiovascular disease mortality and total mortality in the NAS-NRC Twin Registry using a new methodology that allowed for censored observations of outcomes, environmental covariates, and unmeasured genotype-environment interactions.
Detailed description
BACKGROUND:
Methodologically, statistical methods in genetics and epidemiology have developed largely independently; and as a result, there seemed to be little communication between the two fields. Some of the most important hypotheses regarding familial aggregation of chronic diseases related to gene-environment interactions which drew on both fields. The method of analysis used in this study dealt simultaneously with survival time nature of the outcome variable, multiple and continuous environmental risk factors, and correlation in outcomes between related individuals.
The study was supported by the Small Grants Program established by the National Heart, Lung, and Blood Institute in January 1990 to extend analyses of research data generated by clinical trials, population research, and demonstration and education studies.
DESIGN NARRATIVE:
Data available from two epidemiologic questionnaires administered ten years apart were used to determine the extent to which an increased familial risk in cardiovascular disease mortality among twins was mediated by similarities in behavioral risk factors such as smoking, diet, weight changes, physical activity, and socioeconomic variables. The contributions of genetic and environmental factors to twin similarities in health behavior were also examined.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Study design
Who may qualify
- Ages
- Up to 100 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Mar 2016.
- Background: PubMed 1508241Carmelli D, Swan GE, Robinette D, Fabsitz R. Genetic influence on smoking--a study of male twins. N Engl J Med. 1992 Sep 17;327(12):829-33. doi: 10.1056/NEJM199209173271201.
- Background: PubMed 7779316Carmelli D, Swan GE, Cardon LR. Genetic mediation in the relationship of education to cognitive function in older people. Psychol Aging. 1995 Mar;10(1):48-53. doi: 10.1037//0882-7974.10.1.48.
- Background: PubMed 7832265Swan GE, Carmelli D. Characteristics associated with excessive weight gain after smoking cessation in men. Am J Public Health. 1995 Jan;85(1):73-7. doi: 10.2105/ajph.85.1.73.
- Background: PubMed 8079995Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet. 1994 Sep;55(3):566-73.
- Background: PubMed 8055120Carmelli D, Selby JV, Quiroga J, Reed T, Fabsitz RR, Christian JC. 16-year incidence of ischemic heart disease in the NHLBI twin study. A classification of subjects into high- and low-risk groups. Ann Epidemiol. 1994 May;4(3):198-204. doi: 10.1016/1047-2797(94)90097-3.
- Background: PubMed 8021487Carmelli D, Robinette D, Fabsitz R. Concordance, discordance and prevalence of hypertension in World War II male veteran twins. J Hypertens. 1994 Mar;12(3):323-8.
- Background: PubMed 8400834Carmelli D, Swan GE, Robinette D. The relationship between quitting smoking and changes in drinking in World War II veteran twins. J Subst Abuse. 1993;5(2):103-16. doi: 10.1016/0899-3289(93)90055-g.
- Background: PubMed 8349101Carmelli D, Heath AC, Robinette D. Genetic analysis of drinking behavior in World War II veteran twins. Genet Epidemiol. 1993;10(3):201-13. doi: 10.1002/gepi.1370100306.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Heart Diseases, run by National Heart, Lung, and Blood Institute (NHLBI).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 16 Mar 2016. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00005266, which also lists 8 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Mar 2016.