Cardiovascular DiseasesNCT00005178
Study of Children's Activity and Nutrition (SCAN)
An observational study of Cardiovascular Diseases and Heart Diseases, run by Augusta University.
Trial summary
In the first study, to identify children at high and low risk for cardiovascular disease and study their nutritional and physical activity behaviors as they relate to cardiovascular disease. Read more about this study
- Who is it for?
- Ages Up to 100 years, men only
- Conditions the study is for
- Cardiovascular Diseases, Heart Diseases, Coronary Disease
- How many people
- Not given
- Where
- No sites listed yet
- Study dates
- Sep 1985to Aug 1991
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Up to 100 years
- Men only
- No healthy volunteers
- Child, Adult, Older adult
No eligibility criteria
About this study
In the first study, to identify children at high and low risk for cardiovascular disease and study their nutritional and physical activity behaviors as they relate to cardiovascular disease. In the second study, to make yearly assessments over a four year period of diet and physical activity among children and their parents. The initial effort redefined and retested methods to collect data on dietary intake and activity levels of young children.
Read the detailed description
BACKGROUND:
In the past several decades, relationships between various lifestyle behaviors and the development of cardiovascular risk factors have been identified. Nutritional status/eating behaviors and physical activity patterns both directly and indirectly are related to the development of coronary heart disease. For example, obesity, which may be a result of both eating and physical activity behaviors, greatly increases the risk of hypertension, hyperlipidemia, and diabetes mellitus, placing the individuals at greater risk for coronary heart disease. Dietary factors such as composition in fatty acids and cholesterol, composition in vegetable protein and complex carbohydrates, caloric excess and a high intake of salt also are related to the development of risk of coronary heart disease.
Physical activity in adults has also been correlated with coronary heart disease. Epidemiological research has demonstrated that increased physical activity is associated with reduced risk of myocardial infarctions. Regular physical exercise has been shown to have beneficial effects on relative weight and obesity and may act indirectly to beneficially affect hypertension, hypertriglyceridemia and glucose intolerance and raise HDL cholesterol levels. However, in 1985 when SCAN was initiated, little information was available concerning the development of nutritional status/eating behaviors and routine physical activity patterns in children.
Various psychosocial factors have been associated with increased risk of coronary heart disease. Among these factors are behavioral characteristics such as type A behaviors and coping styles to stressors. However, relatively little was known in 1985 concerning the development of such characteristics in children and when these characteristics became associated with risk of cardiovascular disease.
SCAN initiated on the recommendations of the Preventive Cardiology Branch Task Force Group in the Five Year Forward Plan 1982-1987, the Conference on School Health Education Research in the Heart, Lung, and Blood Areas, and the Clinical Applications and Prevention Advisory Committee of the National Heart, Lung, and Blood Institute. A Request for Applications was released in October 1984. In 1985, six grants were awarded as part of the Study of Children's Activity and Nutrition (SCAN).
DESIGN NARRATIVE:
There were six projects supported by the SCAN program. They did not follow a common protocol but were basically similar.
Medical College of Georgia: Five hundred and one Black and white children were followed over a four year period for food intake behavior, physical activity and fitness, anthropometric measurements, blood lipids and lipoproteins, heart rate and blood pressure, and psychologic characteristics associated with coronary heart disease.
West Virginia University: Two hundred and eight predominantly white children of adults followed since adolescence in the Bourbon County Study were members of this cohort. Children participated in cardiovascular fitness tests, and underwent blood pressure measurements, and serum lipid determinations. The effects of television-viewing, child-rearing patterns, exercise, and nutrition-related knowledge and attitudes were assessed over a four year period.
Columbia University: Seven hundred and ninety-four primarily Hispanic children and their parents were followed for four years to determine the extent to which diet and physical activity predict coronary heart disease risk. Cross sectional and longitudinal analyses were performed.
Georgetown University: Five hundred and seventy Black children were followed for the influence of the risk status of an older sibling and day care versus home care on nutrient intake and physical activity. Eating events were videotaped, activity levels were recorded, and measurements were obtained on height, weight, cholesterol, blood pressure, and skinfold thickness. Dietary recalls and nutrition knowledge surveys were obtained.
University of Massachusetts: In the Framingham Children's Study, one hundred children who were direct descendents of Framingham Heart Study participants were followed for four years. Measurements included height, weight, skinfold thickness, lipid profiles, heart rate and activity monitoring, and assessment of dietary intake four times per year.
Memphis State University: Six hundred and sixty-three children and their parents were assessed for food intake, physical activity, and parent-child interactions related to food intake and exercise. Anthropometric and cardiovascular data were also collected every four months for four years.
Two of the studies were renewed in FY 1992 and again in FY 1996. See the Framingham Children's Study and the Children's Activity and Nutrition III.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension, Obesity, Hypercholesterolemia
- Medical subject headings
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension, Obesity, Hypercholesterolemia
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 May 2000 (estimated)
- Study startSep 1985
- Study completionAug 1991
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (47)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
Sponsor and investigators
- Lead sponsor
- Augusta University
- Sponsor type
- University, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Investigators
- R. EllisonRonald IannottiRobert KlesgesJane KotchenWilliam Strong
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00005178
- Sponsor's protocol ID
- 1056
- Other IDs
- R01HL035073
- Status last verified
- Dec 2000
- First submitted
- 25 May 2000
- Last updated
- 23 Dec 2015
- Results posted
- No
Publications
Hulse E, Strong WB. Preparticipation evaluation for athletics. Pediatr Rev. 1987 Dec;9(6):173-82. doi: 10.1542/pir.9-6-173. No abstract available.
PubMed 3332373Strong WB, Wilmore JH: Unfit Kids: An Office-Based Approach to Physical Fitness. Contemp Pediatr, 4:33-48, 1988
Strong WB. So what's good about sports? Am J Dis Child. 1988 Feb;142(2):143. doi: 10.1001/archpedi.1988.02150020041023. No abstract available.
PubMed 3341313Strong WB, Dennison BA. Pediatric preventive cardiology: atherosclerosis and coronary heart disease. Pediatr Rev. 1988 Apr;9(10):303-14. doi: 10.1542/pir.9-10-303. No abstract available.
PubMed 3054834Strong WB (Ed): In: The Pediatrician of the 90's. Biomedical Information Corporation, 1988
Arensman FW, Treiber FA, Gruber MP, Strong WB. Exercise-induced differences in cardiac output, blood pressure, and systemic vascular resistance in a healthy biracial population of 10-year-old boys. Am J Dis Child. 1989 Feb;143(2):212-6. doi: 10.1001/archpedi.1989.02150140106030.
PubMed 2916494Treiber FA, Musante L, Strong WB, Levy M. Racial differences in young children's blood pressure. Responses to dynamic exercise. Am J Dis Child. 1989 Jun;143(6):720-3. doi: 10.1001/archpedi.1989.02150180102029.
PubMed 2729217Treiber FA, Musante L, Hartdagan S, Davis H, Levy M, Strong WB. Validation of a heart rate monitor with children in laboratory and field settings. Med Sci Sports Exerc. 1989 Jun;21(3):338-42.
PubMed 2733584Treiber FA, Mabe PA 3rd, Riley W, Carr T, Levy M, Thompson W, Strong WB. Assessment of children's Type A behavior: relationship with negative behavioral characteristics and children and teacher demographic characteristics. J Pers Assess. 1989 Winter;53(4):770-82. doi: 10.1207/s15327752jpa5304_13.
PubMed 2607405Musante L, Treiber FA, Strong WB, Levy M. Family history of hypertension and cardiovascular reactivity to forehead cold stimulation in black male children. J Psychosom Res. 1990;34(1):111-6. doi: 10.1016/0022-3999(90)90014-u.
PubMed 2313609Strong WB. Physical activity and children. Circulation. 1990 May;81(5):1697-701. doi: 10.1161/01.cir.81.5.1697. No abstract available.
PubMed 2184948Musante L, Treiber FA, Strong WB, Levy M. Individual and cross-spouse correlations of perceptions of family functioning, blood pressure and dimensions of anger. J Psychosom Res. 1990;34(4):393-9. doi: 10.1016/0022-3999(90)90062-9.
PubMed 2376840Segal KR, Gutin B, Presta E, Wang J, Van Itallie TB. Estimation of human body composition by electrical impedance methods: a comparative study. J Appl Physiol (1985). 1985 May;58(5):1565-71. doi: 10.1152/jappl.1985.58.5.1565.
PubMed 3997721Gutin B, Alejandro D, Duni T, Segal K, Phillips GB. Levels of serum sex hormones and risk factors for coronary heart disease in exercise-trained men. Am J Med. 1985 Jul;79(1):79-84. doi: 10.1016/0002-9343(85)90549-2.
PubMed 3893124Gutin B: Basic Principles of Training and Fitness. Contemporary OB/GYN. Special Issue on The Active Women, May 1985
Study at a glance
From the registry record, last updated by the sponsor on 23 Dec 2015. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Study of Children's Activity and Nutrition (SCAN)
- ClinicalTrials.gov ID
- NCT00005178
- Acronym / sponsor ID
- 1056
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Hypertension, Obesity, Hypercholesterolemia
- Study type
- Observational
- Recruitment status
- Completed
- Lead sponsor
- Augusta UniversityUniversity, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Study start
- Sep 1985
- Study completion
- Aug 1991
- First posted
- 26 May 2000 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
In the first study, to identify children at high and low risk for cardiovascular disease and study their nutritional and physical activity behaviors as they relate to cardiovascular disease. In the second study, to make yearly assessments over a four year period of diet and physical activity among children and their parents. The initial effort redefined and retested methods to collect data on dietary intake and activity levels of young children.
Detailed description
BACKGROUND:
In the past several decades, relationships between various lifestyle behaviors and the development of cardiovascular risk factors have been identified. Nutritional status/eating behaviors and physical activity patterns both directly and indirectly are related to the development of coronary heart disease. For example, obesity, which may be a result of both eating and physical activity behaviors, greatly increases the risk of hypertension, hyperlipidemia, and diabetes mellitus, placing the individuals at greater risk for coronary heart disease. Dietary factors such as composition in fatty acids and cholesterol, composition in vegetable protein and complex carbohydrates, caloric excess and a high intake of salt also are related to the development of risk of coronary heart disease.
Physical activity in adults has also been correlated with coronary heart disease. Epidemiological research has demonstrated that increased physical activity is associated with reduced risk of myocardial infarctions. Regular physical exercise has been shown to have beneficial effects on relative weight and obesity and may act indirectly to beneficially affect hypertension, hypertriglyceridemia and glucose intolerance and raise HDL cholesterol levels. However, in 1985 when SCAN was initiated, little information was available concerning the development of nutritional status/eating behaviors and routine physical activity patterns in children.
Various psychosocial factors have been associated with increased risk of coronary heart disease. Among these factors are behavioral characteristics such as type A behaviors and coping styles to stressors. However, relatively little was known in 1985 concerning the development of such characteristics in children and when these characteristics became associated with risk of cardiovascular disease.
SCAN initiated on the recommendations of the Preventive Cardiology Branch Task Force Group in the Five Year Forward Plan 1982-1987, the Conference on School Health Education Research in the Heart, Lung, and Blood Areas, and the Clinical Applications and Prevention Advisory Committee of the National Heart, Lung, and Blood Institute. A Request for Applications was released in October 1984. In 1985, six grants were awarded as part of the Study of Children's Activity and Nutrition (SCAN).
DESIGN NARRATIVE:
There were six projects supported by the SCAN program. They did not follow a common protocol but were basically similar.
Medical College of Georgia: Five hundred and one Black and white children were followed over a four year period for food intake behavior, physical activity and fitness, anthropometric measurements, blood lipids and lipoproteins, heart rate and blood pressure, and psychologic characteristics associated with coronary heart disease.
West Virginia University: Two hundred and eight predominantly white children of adults followed since adolescence in the Bourbon County Study were members of this cohort. Children participated in cardiovascular fitness tests, and underwent blood pressure measurements, and serum lipid determinations. The effects of television-viewing, child-rearing patterns, exercise, and nutrition-related knowledge and attitudes were assessed over a four year period.
Columbia University: Seven hundred and ninety-four primarily Hispanic children and their parents were followed for four years to determine the extent to which diet and physical activity predict coronary heart disease risk. Cross sectional and longitudinal analyses were performed.
Georgetown University: Five hundred and seventy Black children were followed for the influence of the risk status of an older sibling and day care versus home care on nutrient intake and physical activity. Eating events were videotaped, activity levels were recorded, and measurements were obtained on height, weight, cholesterol, blood pressure, and skinfold thickness. Dietary recalls and nutrition knowledge surveys were obtained.
University of Massachusetts: In the Framingham Children's Study, one hundred children who were direct descendents of Framingham Heart Study participants were followed for four years. Measurements included height, weight, skinfold thickness, lipid profiles, heart rate and activity monitoring, and assessment of dietary intake four times per year.
Memphis State University: Six hundred and sixty-three children and their parents were assessed for food intake, physical activity, and parent-child interactions related to food intake and exercise. Anthropometric and cardiovascular data were also collected every four months for four years.
Two of the studies were renewed in FY 1992 and again in FY 1996. See the Framingham Children's Study and the Children's Activity and Nutrition III.
Study design
Who may qualify
- Ages
- Up to 100 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Dec 2015.
- Background: PubMed 3332373Hulse E, Strong WB. Preparticipation evaluation for athletics. Pediatr Rev. 1987 Dec;9(6):173-82. doi: 10.1542/pir.9-6-173. No abstract available.
- BackgroundStrong WB, Wilmore JH: Unfit Kids: An Office-Based Approach to Physical Fitness. Contemp Pediatr, 4:33-48, 1988
- Background: PubMed 3341313Strong WB. So what's good about sports? Am J Dis Child. 1988 Feb;142(2):143. doi: 10.1001/archpedi.1988.02150020041023. No abstract available.
- Background: PubMed 3054834Strong WB, Dennison BA. Pediatric preventive cardiology: atherosclerosis and coronary heart disease. Pediatr Rev. 1988 Apr;9(10):303-14. doi: 10.1542/pir.9-10-303. No abstract available.
- BackgroundStrong WB (Ed): In: The Pediatrician of the 90's. Biomedical Information Corporation, 1988
- Background: PubMed 2916494Arensman FW, Treiber FA, Gruber MP, Strong WB. Exercise-induced differences in cardiac output, blood pressure, and systemic vascular resistance in a healthy biracial population of 10-year-old boys. Am J Dis Child. 1989 Feb;143(2):212-6. doi: 10.1001/archpedi.1989.02150140106030.
- Background: PubMed 2729217Treiber FA, Musante L, Strong WB, Levy M. Racial differences in young children's blood pressure. Responses to dynamic exercise. Am J Dis Child. 1989 Jun;143(6):720-3. doi: 10.1001/archpedi.1989.02150180102029.
- Background: PubMed 2733584Treiber FA, Musante L, Hartdagan S, Davis H, Levy M, Strong WB. Validation of a heart rate monitor with children in laboratory and field settings. Med Sci Sports Exerc. 1989 Jun;21(3):338-42.
- Background: PubMed 2607405Treiber FA, Mabe PA 3rd, Riley W, Carr T, Levy M, Thompson W, Strong WB. Assessment of children's Type A behavior: relationship with negative behavioral characteristics and children and teacher demographic characteristics. J Pers Assess. 1989 Winter;53(4):770-82. doi: 10.1207/s15327752jpa5304_13.
- Background: PubMed 2313609Musante L, Treiber FA, Strong WB, Levy M. Family history of hypertension and cardiovascular reactivity to forehead cold stimulation in black male children. J Psychosom Res. 1990;34(1):111-6. doi: 10.1016/0022-3999(90)90014-u.
- Background: PubMed 2184948Strong WB. Physical activity and children. Circulation. 1990 May;81(5):1697-701. doi: 10.1161/01.cir.81.5.1697. No abstract available.
- Background: PubMed 2376840Musante L, Treiber FA, Strong WB, Levy M. Individual and cross-spouse correlations of perceptions of family functioning, blood pressure and dimensions of anger. J Psychosom Res. 1990;34(4):393-9. doi: 10.1016/0022-3999(90)90062-9.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
R. Ellison
Ronald Iannotti
Robert Klesges
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Heart Diseases, run by Augusta University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 23 Dec 2015. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00005178, which also lists 47 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Dec 2015.