Cardiovascular DiseasesNCT00000460
Training Levels Comparison Trial
An observational study of Cardiovascular Diseases and Coronary Disease, run by University of Alabama at Birmingham.
Trial summary
To determine the effects of high or low intensity long-term exercise conditioning in patients with coronary artery disease. Read more about this study
- Who is it for?
- Ages 30 to 67 years, men only
- Conditions the study is for
- Cardiovascular Diseases, Coronary Disease, Heart Diseases
- What is being tested?
- Low intensity exercise and High intensity exercise
- Type of treatment
- Lifestyle or therapy programme
- How many people
- 0 participants
- Where
- No sites listed yet
- Study dates
- Dec 1986to Mar 1991
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 30 to 67 years
- Men only
- No healthy volunteers
- Adult, Older adult
Study population: Men between the ages of 30 and 67 who respond to an advertisement for research participants.
Men, ages 30 to 67, with documented coronary heart disease.
About this study
Official title: Training Levels Comparison (TLC) Trial in Patients With Coronary Heart Disease
To determine the effects of high or low intensity long-term exercise conditioning in patients with coronary artery disease.
Read the detailed description
BACKGROUND:
A vast amount of literature exists on the improvements in work capacity, reduction of risk factors, and an increased feeling of well-being among coronary heart disease patients after physical training programs. Previous observations of short-term training programs which resulted in an increase in physical working capacity have not usually shown a cardiac change. The National Exercise and Heart Disease Project did not show such changes, but the exercise level may have been inadequate. Several other studies suggested that more prolonged and intense training could result in improved cardiac function.
DESIGN NARRATIVE:
Patients were randomized to high intensity or low intensity long-term exercise groups. Compliance was strengthened by randomizing following a sequence of eligibility visits and after a test period of subject reaction to an exercise program. The primary endpoint was change in exercise ejection fraction at one year. Secondary endpoints included changes in lipid levels, body composition, blood pressure and heart rate measurements, glucose tolerance, quality of life measures, compliance, and progression of disease. Patients were classified into one of four strata based on the documented history of myocardial infarction and resting left ventricular ejection fraction. Within each stratum, patients were assigned in equal numbers to the two intensity levels of exercise intervention. All exercise prescriptions were based on exercise testing of patients maintained on their usual medical regimen including drugs. Patients underwent standardized multistage treadmill exercise testing monitored by Doppler echocardiogram at baseline, just prior to randomization and at the three month, six month, one year and two year visits. Patients participated in the structured group exercise sessions three days per week. Each exercise session was preceded by and ended with a five to fifteen minute warm-up and cool-down session. Each patient was given an exercise prescription that included a 30 minute period of walking or of walking and jogging sequences and 15 minutes of arm-leg bicycle ergometer exercise. Recruitment started in May 1987. The last patient was enrolled in March 1990.
- Being tested
- Low intensity exercise, High intensity exercise
- Medical subject headings
- Cardiovascular Diseases, Coronary Disease, Heart Diseases, Myocardial Ischemia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Low intensity exerciseBehavioural
High intensity exerciseBehavioural
| Study group | Role | What they receive |
|---|---|---|
| Low intensity exercise | Not described Receives: Behavioral: Low intensity exercise | |
| High intensity exercise | Not described Receives: Behavioral: High intensity exercise |
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 1999 (estimated)
- Study startDec 1986
- Primary completionMar 1991
- Study completionMar 1991
Why it stopped: due to lack of enrollment
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (4)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular DiseasesStudies of the same condition, open and under way.
- More trials run by University of Alabama at BirminghamThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 0 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Alabama at Birmingham
- Sponsor type
- University, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Responsible party
- Sponsor
- Investigators
- Albert Oberman, Principal investigator, University of Alabama at Birmingham
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00000460
- Sponsor's protocol ID
- 49
- Other IDs
- R01HL037597
- Status last verified
- Nov 2013
- First submitted
- 27 Oct 1999
- Last updated
- 6 Jan 2016
- Results posted
- No
Publications
Lee JY, Oberman A, Fletcher GF, Raczynski JM, Fletcher BJ, Nanda NC, Jensen BE. Design of the training levels comparison trial. Control Clin Trials. 1994 Feb;15(1):59-76. doi: 10.1016/0197-2456(94)90028-0.
PubMed 8149771Kim JR, Oberman A, Fletcher GF, Lee JY. Effect of exercise intensity and frequency on lipid levels in men with coronary heart disease: Training Level Comparison Trial. Am J Cardiol. 2001 Apr 15;87(8):942-6; A3. doi: 10.1016/s0002-9149(01)01425-4.
PubMed 11305982Jensen BE, Fletcher BJ, Rupp JC, Fletcher GF, Lee JY, Oberman A. Training level comparison study. Effect of high and low intensity exercise on ventilatory threshold in men with coronary artery disease. J Cardiopulm Rehabil. 1996 Jul-Aug;16(4):227-32. doi: 10.1097/00008483-199607000-00003.
PubMed 8872288Lee JY, Jensen BE, Oberman A, Fletcher GF, Fletcher BJ, Raczynski JM. Adherence in the training levels comparison trial. Med Sci Sports Exerc. 1996 Jan;28(1):47-52. doi: 10.1097/00005768-199601000-00013.
PubMed 8775354
Study at a glance
From the registry record, last updated by the sponsor on 6 Jan 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Training Levels Comparison (TLC) Trial in Patients With Coronary Heart Disease
- ClinicalTrials.gov ID
- NCT00000460
- Acronym / sponsor ID
- 49
- Study type
- Observational
- Recruitment status
- WithdrawnReason stopped: due to lack of enrollment
- Enrolment
- 0 participants (actual)
- Lead sponsor
- University of Alabama at BirminghamUniversity, hospital or other
- Collaborators
- National Heart, Lung, and Blood Institute (NHLBI)
- Study start
- Dec 1986
- Primary completion
- Mar 1991 (actual)
- Study completion
- Mar 1991 (actual)
- First posted
- 28 Oct 1999 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
To determine the effects of high or low intensity long-term exercise conditioning in patients with coronary artery disease.
Detailed description
BACKGROUND:
A vast amount of literature exists on the improvements in work capacity, reduction of risk factors, and an increased feeling of well-being among coronary heart disease patients after physical training programs. Previous observations of short-term training programs which resulted in an increase in physical working capacity have not usually shown a cardiac change. The National Exercise and Heart Disease Project did not show such changes, but the exercise level may have been inadequate. Several other studies suggested that more prolonged and intense training could result in improved cardiac function.
DESIGN NARRATIVE:
Patients were randomized to high intensity or low intensity long-term exercise groups. Compliance was strengthened by randomizing following a sequence of eligibility visits and after a test period of subject reaction to an exercise program. The primary endpoint was change in exercise ejection fraction at one year. Secondary endpoints included changes in lipid levels, body composition, blood pressure and heart rate measurements, glucose tolerance, quality of life measures, compliance, and progression of disease. Patients were classified into one of four strata based on the documented history of myocardial infarction and resting left ventricular ejection fraction. Within each stratum, patients were assigned in equal numbers to the two intensity levels of exercise intervention. All exercise prescriptions were based on exercise testing of patients maintained on their usual medical regimen including drugs. Patients underwent standardized multistage treadmill exercise testing monitored by Doppler echocardiogram at baseline, just prior to randomization and at the three month, six month, one year and two year visits. Patients participated in the structured group exercise sessions three days per week. Each exercise session was preceded by and ended with a five to fifteen minute warm-up and cool-down session. Each patient was given an exercise prescription that included a 30 minute period of walking or of walking and jogging sequences and 15 minutes of arm-leg bicycle ergometer exercise. Recruitment started in May 1987. The last patient was enrolled in March 1990.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Low intensity exercise | – | Behavioral: Low intensity exercise |
| High intensity exercise | – | Behavioral: High intensity exercise |
Who may qualify
- Ages
- 30 to 67 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Men between the ages of 30 and 67 who respond to an advertisement for research participants.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Low intensity exercise | Behavioural | Low intensity exercise |
| High intensity exercise | Behavioural | High intensity exercise |
Primary outcome
Not reported in the source record.
Results and safety
The study was withdrawn before enrolling participants, so there are no results.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 6 Jan 2016.
- Background: PubMed 8149771Lee JY, Oberman A, Fletcher GF, Raczynski JM, Fletcher BJ, Nanda NC, Jensen BE. Design of the training levels comparison trial. Control Clin Trials. 1994 Feb;15(1):59-76. doi: 10.1016/0197-2456(94)90028-0.
- Background: PubMed 11305982Kim JR, Oberman A, Fletcher GF, Lee JY. Effect of exercise intensity and frequency on lipid levels in men with coronary heart disease: Training Level Comparison Trial. Am J Cardiol. 2001 Apr 15;87(8):942-6; A3. doi: 10.1016/s0002-9149(01)01425-4.
- Background: PubMed 8872288Jensen BE, Fletcher BJ, Rupp JC, Fletcher GF, Lee JY, Oberman A. Training level comparison study. Effect of high and low intensity exercise on ventilatory threshold in men with coronary artery disease. J Cardiopulm Rehabil. 1996 Jul-Aug;16(4):227-32. doi: 10.1097/00008483-199607000-00003.
- Background: PubMed 8775354Lee JY, Jensen BE, Oberman A, Fletcher GF, Fletcher BJ, Raczynski JM. Adherence in the training levels comparison trial. Med Sci Sports Exerc. 1996 Jan;28(1):47-52. doi: 10.1097/00005768-199601000-00013.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Albert Oberman principal investigator
University of Alabama at Birmingham
Questions about this trial
What is this clinical trial studying?
An observational study of Cardiovascular Diseases and Coronary Disease, run by University of Alabama at Birmingham.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: withdrawn, as of the sponsor's last update on 6 Jan 2016. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study was withdrawn before enrolling participants, so there are no results.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00000460, which also lists 4 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 6 Jan 2016.