Research institution
Uppsala University Clinical Trials
Studies where Uppsala University is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 76Relapsing-remitting Multiple Sclerosis
The HIt HArd and hiT Early in Multiple Sclerosis Trial
The HiHat trial is a Phase 2 study aimed at evaluating the safety and feasibility of sequential treatment with rituximab and cladribine in patients with relapsing-remitting multiple sclerosis (RRMS).
- Trial name
- HiHat (NCT07517185)
- Testing
- Sequential treatment with rituximab and cladribine
- Where
- 4 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Psychoses, Metabolic Syndrome
Targeted Health Dialogues for Individuals With Psychosis Spectrum Disorders
People with psychotic disorders are at a higher risk of premature death than the general population. Adverse lifestyle factors contribute to this reduced life expectancy; such factors may include high consumption of tobacco and…
- Trial name
- NCT07888894
- Testing
- Targeted Health Dialogues
- Volunteers
- 60 people
- Sponsor
- Uppsala University
Burnout, Clinical Burnout
Comparing ACT, Recuperation, and ACT Plus Vocational Support for Clinical Burnout
This study compares three different online psychological treatments for people with clinical burnout (stress-related exhaustion) who are on sick leave or have major difficulties coping at work or in daily life.
- Conditions
- Burnout, Clinical Burnout, Exhaustion Disorder
- Trial name
- NCT07272421
- Testing
- ACT, Recuperation, Vocational support
- Where
- Sweden
- Volunteers
- 210 people
- Sponsor
- Uppsala University
Depression
Behavioral Activation for the Treatment of Depression in Older Adults
Depression affects between 5-15% of adults ≥ 65 years in Sweden. Depression in older adults reduces functional ability and quality of life, and increases the risk for morbidity, loneliness, and suicide.
- Trial name
- DepActive (NCT06284889)
- Testing
- Behavioural activation, Treatment as usual (TAU)
- Where
- 2 sites in Sweden
- Volunteers
- 81 people
- Sponsor
- Uppsala University
Prostate Cancer
The Case of "Triple" Versus "Double" Therapy for Patients With High Volume Metastatic Hormone Sensitive Prostate Cancer
Lead4Care is an observational, open-label, multicenter study evaluating the effectiveness, tolerance, and cost-effectiveness of triple against double therapy in matched groups of mHSPC patients with high tumor burden.
- Trial name
- Lead4Care (NCT06446401)
- Testing
- ADT + NHT + Docetaxel, ADT + NHT
- Where
- 2 sites in Sweden
- Volunteers
- 1,400 people
- Sponsor
- Uppsala University
Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis
Surgery for Thumb Base Osteoarthritis: Joint Replacement vs. Trapeziectomy
The goal of this clinical trial is to learn if the surgical method with total joint arthroplasty, (TOUCH joint prosthesis), is as good as or better than the traditional surgical method, trapezectomy, to treat thumb base joint…
- Conditions
- Thumb Osteoarthritis, Thumb Carpometacarpal Joint Osteoarthritis, Carpometacarpal (CMC) Joint Arthritis, Basal Thumb Osteoartrithis
- Trial name
- BASTION (NCT07569549)
- Testing
- Implantation of trapeziometacarpal prosthesis, Trapeziectomy with Capsuloplasty
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- Uppsala University
Osteoarthritis, Osteonecrosis
E-Type - Early Wear of Polyethylene Liners Used in DMC
This is a single-centre, randomized, double-blinded controlled non-inferiority trial that will be conducted at the Orthopaedic Department at Uppsala University Hospital, Uppsala.
- Conditions
- Osteoarthritis, Osteonecrosis, Dysplasia; Hip
- Trial name
- E-type (NCT07863557)
- Testing
- Total Hip Arthroplasty
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Cardiac Disease, Depression and Quality of Life
Evaluation of a Remote Behavioural Stress Recovery Intervention for Myocardial Infarction Patients Younger Than Fifty-five (BRIM-55): A Feasibility Study
The goal of this feasibility study is to learn if the randomised controlled trial evaluating the Remote-delivery Balance in Everyday Life (rBEL) programme for adults younger than 55 years who have experienced a myocardial…
- Conditions
- Cardiac Disease, Depression and Quality of Life, Cardiac Distress, Myocardial Infarction
- Trial name
- BRIM-55 (NCT07706816)
- Testing
- Remote-delivery Balance in Everyday Life (rBEL) Program for Myocardial Infarction Patients Younger Than 55 Years With Cardiac Distress
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Transurethral Resection of Prostate Syndrome, Prostate Hyperplasia
Transurethral Prostate Resection (TURP) vs. Prostate Artery Embolization (PAE)
This study focuses on the treatment of benign prostatic hyperplasia which causes lower urinary tract symptoms. The purpose of the research project is to evaluate PAE in terms of both medical and health economic outcomes.
- Conditions
- Transurethral Resection of Prostate Syndrome, Prostate Hyperplasia, Embolization, Therapeutic
- Trial name
- NCT05531240
- Testing
- Prostate Artery Embolization, Transurethral Prostate Resection (TURP)
- Where
- 4 sites in Sweden
- Volunteers
- 104 people
- Sponsor
- Uppsala University
Hip Arthroplasty
Randomized Study of Surgical Approach of Total Hip Arthroplasty (THA).
This study intends to analyze the healing process of the hip muscle system and to evaluate the functional recovery score after performing a cemented primary THA for osteoarthritis (OA).
- Trial name
- NCT07851597
- Testing
- Total hip arthroplasty
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Uppsala University
Completed, with results posted
All –Acute Coronary Syndrome (ACS)
PROSPECT II & PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial.
The present study has two components, an overall prospective observational study using multimodality imaging (PROSPECT II) that will examine the natural history of patients with unstable atherosclerotic coronary artery disease…
- Trial name
- P2 (NCT02171065)
- Testing
- ABSORB BVS
- Where
- Sweden
- Volunteers
- 902 people
- Sponsor
- Uppsala University
Stroke
Effect of Intensified Physical Activity for Patients With Stroke - a Combined Physical and Behavioural Approach
Chronic conditions such as stroke are associated with physical disability and an economic burden for the family and the society.
- Trial name
- NCT01161329
- Testing
- High-Intensity Functional Exercise Programmes (HIFE)
- Where
- Sweden
- Volunteers
- 67 people
- Sponsor
- Uppsala University