Research institution
University Hospital, Clermont-Ferrand Clinical Trials
Studies where University Hospital, Clermont-Ferrand is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 145Chronic Pain
Cohort of Chronic Pain Patients
Chronic pain affects approximately 20% of adults, 50% of the elderly population and over 1.5 billion people worldwide. Societal and economic issues are also crucial, as 60% of people with pain are less able or unable to work and…
- Trial name
- e-DOL cohort (NCT04880096)
- Testing
- eDOL
- Where
- 22 sites in France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myocardial Infarction (MI), Sudden Cardiac Death Due to Cardiac Arrhythmia
ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Cardiac Death in Moderated LVEF in ischEmic cardiomyopathY
Although advances in treatment and patient management have considerably improved post-infarction prognosis, the risk of sudden cardiac death remains a major concern.
- Trial name
- ODISSEY (NCT07545512)
- Testing
- This study involved an auxillary CE-marked medical device (implantable holter for cardiac rhythm monitoring)
- Where
- 15 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis - to Reduce Mortality in the Intensive Care Unit, Septic Shock
Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock
Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction and represents a major healthcare problem.
- Trial name
- CARBON (NCT07179276)
- Testing
- CO2gap-guided resuscitation strategy
- Where
- 29 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer, Breast Surgery
Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin
The goal of this clinical trial is to determine whether preoperative antibiotic prophylaxis with cefazolin is necessary to prevent surgical site infections in adult women undergoing breast-conserving surgery (lumpectomy or…
- Conditions
- Breast Cancer, Breast Surgery, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- PROPHY-SEIN (NCT07898943)
- Testing
- Cefazolin 2 g Infusion
- Where
- 33 sites in France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Clermont-Ferrand
Fallers Aged 60 Years and Older, Biomarkers / Blood
Contribution of GFAP and UCH-L1 Assays in Whole Blood to Optimizing Personalized Care for "Repeated Fallers" Hospitalized in Geriatric Wards
The BACHUS study focuses on a population of patients aged 75 years and older who are hospitalized after recurrent falls. The objective is to evaluate the performance of an innovative, personalized biological screening strategy to…
- Conditions
- Fallers Aged 60 Years and Older, Biomarkers / Blood, Intracranial Bleeding
- Trial name
- BACHUS (NCT07342023)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ulcerative Colitis (UC)
FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial
Ulcerative colitis (UC) is a chronic bowel disease. It causes inflammation of the rectum and sometimes the colon. This disease can also affect other parts of the body. It can be very difficult to live with on a daily basis.
- Trial name
- STARTER (NCT07576452)
- Testing
- 1: infliximab 2: filgotinib 3: ustekinumab 4: vedolizumab, 1: ustekinumab 2: vedolizumab 3: infliximab 4: filgotinib, 1: vedolizumab 2: infliximab 3: filgotinib 4: ustekinumab
- Where
- 13 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson s Disease
Primary Parkinsonian Pain: Clinical Association and Phenotype
Among the different types of pain observed in Parkinson's disease, primary parkinsonian pain (PPP) is the most severe, the most difficult to treat, but also the least well characterized and the hardest to describe, not only by…
- Trial name
- PHENOPAIN (NCT07702266)
- Testing
- Online self-administered questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Periodontitis
Evaluation of Masticatory Performance in Patients With Periodontitis
The objective of this observational study is to assess the correlation between the severity of periodontal involvement and masticatory performance in patients with periodontitis.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease
- Trial name
- PAROCHEW (NCT07665489)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Migraine
Suppressive Functions of Regulatory T Cells in Migraine
Migraine is a frequent, disabling condition, of great social and economical impact worldwide. This condition is more frequent in women and subjects with autoimmune and/or inflammatory diseases.
- Trial name
- SIIM-reg (NCT07067112)
- Testing
- Blood sampling, questionnaire and phone call
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Infective Endocarditis (IE)
From Commensalism to Pathogenicity: Exploring the Pathophysiology of Bacteremia to Better Understand Enterococcus Faecalis Infective Endocarditis
Enterococci are pathobionts of the human intestinal microbiota: they colonize the gastrointestinal tract as well as the skin, urine, wounds, bile, the oral cavity and endodontic canal, and medical devices (urinary catheters…
- Trial name
- BAC-ENDO (NCT07313865)
- Testing
- Microbiological sampling (swab collection)
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Clermont-Ferrand
Completed, with results posted
All 2Chronic HCV Infection
Study to Investigate the Efficacy of Elbasvir/Grazoprevir Fixed-Dose Combination for 8 Weeks in Treatment-Naïve, HCV GT1b-Infected Patients, With Non-severe Fibrosis
A Phase 3, Global, Multicenter, Open-Label Study to Investigate the Efficacy of Elbasvir/Grazoprevir Fixed-Dose Combination for 8 Weeks in Treatment-Naïve, HCV GT1b-Infected Patients, with non-severe fibrosis The primary…
- Trial name
- STREAGER (NCT02973503)
- Testing
- Elbasvir/Grazoprevir Fixed Dose Combination
- Where
- France
- Volunteers
- 117 people
- Sponsor
- University Hospital, Clermont-Ferrand
Delirium, Agitation
Effects of Dexmedetomidine on Delirium Duration of Non-intubated ICU Patients (4D Trial)
The primary purpose of the study is to evaluate whether dexmedetomidine is effective in treating agitated delirium of non-intubated ICI patients
- Trial name
- 4D (NCT03317067)
- Testing
- Dexmedetomidine
- Where
- France
- Volunteers
- 168 people
- Sponsor
- University Hospital, Clermont-Ferrand