Research institution
China National Center for Cardiovascular Diseases Clinical Trials
Studies where China National Center for Cardiovascular Diseases is the lead sponsor: what is enrolling now, by phase, condition and country.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 108Postoperative Atrial Fibrillation, Coronary Artery Disease
Partial Cardiac Denervation for Preventing Atrial Fibrillation After CABG
Postoperative atrial fibrillation (POAF) is the most common arrhythmia following cardiac surgery and is associated with increased risks of mortality, stroke, myocardial infarction, and hospital readmission.
- Trial name
- CALM (NCT07918781)
- Testing
- Partial Cardiac Denervation
- Where
- 5 sites in China
- Volunteers
- 1,470 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertension, Hyperglycemia
Multimodal AI-Driven Out-of-Hospital Management for Hypertension and Cardiometabolic Risk
High blood pressure often occurs together with abnormal blood glucose, abnormal blood lipids, or abdominal obesity. Managing these conditions outside the hospital can be difficult.
- Conditions
- Hypertension, Hyperglycemia, Dyslipidemia
- Trial name
- no acronym (NCT07917676)
- Testing
- Hybrid AI-Enabled Out-of-Hospital Health Management, Standard Out-of-Hospital Guidance
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Embolism
Reduced-Dose Thrombolysis in Intermediate-Risk Pulmonary Embolism With High-Risk Features
Alteplase, a recombinant tissue plasminogen activator (rt-PA), is commonly used for thrombolytic treatment in patients with high-risk acute pulmonary thromboembolism (PTE), whereas the role of thrombolysis in intermediate-risk…
- Trial name
- REDUCTION (NCT07917078)
- Testing
- Alteplase, Standard Anticoagulation
- Where
- 26 sites in China
- Volunteers
- 270 people
- Sponsor
- China National Center for Cardiovascular Diseases
Chronic Coronary Syndrome
Out-Patient Proactive Observation With Wearable-Assisted Tracking for Cardiovascular Health Management
The goal of this randomized controlled study is to evaluate whether a wearable device-based, Life's Essential 8 (LE8)-guided management strategy can improve cardiovascular health in patients with chronic coronary syndrome (CCS).
- Trial name
- OPPO-WATCH (NCT07912671)
- Testing
- Wearable Device-Based Monitoring and LE8 Feedback, Routine Outpatient Care With Data-Blinded Wearable Monitoring
- Where
- China
- Volunteers
- 400 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Vasopressor Agents in Pulmonary Hypertension Crisis
Comparison of the efficacy and safety of three vasoactive agents-dopamine, norepinephrine, and epinephrine-in the treatment of patients with pulmonary hypertension crisis: prospective, randomised controlled trial monitored by…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Hypertension, Pulmonary
- Trial name
- NCT07667829
- Testing
- Norepinephrine, Dopamine, Epinephrine
- Where
- 3 sites in China
- Volunteers
- 75 people
- Sponsor
- China National Center for Cardiovascular Diseases
Leadless Pacemaker, Transthoracic Echocardiography
Ultrasound Guided Leadless Pacemaker Implantation
The leadless pacemaker is a novel pacing technology that has emerged in recent years. Compared with conventional lead pacemakers, its design avoids many complications associated with leads and pacemaker pockets, including lead…
- Trial name
- NCT07857330
- Testing
- Transthoracic echocardiography-guided, Conventional fluoroscopy-guided, Leadless pacemaker
- Volunteers
- 288 people
- Sponsor
- China National Center for Cardiovascular Diseases
Ventricular Tachycardia (VT), Ischemic Cardiomyopathy
MRI-guided Ventricular Tachycardia Ablation in Patients With Structural Heart Disease
Ventricular tachycardia (VT) is a life-threatening heart rhythm disorder that frequently occurs in patients with structural heart disease, such as ischemic or non-ischemic cardiomyopathy.
- Conditions
- Ventricular Tachycardia (VT), Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- MAGNET-VT (NCT07896980)
- Testing
- LGE-MRI-integrated EAM-guided catheter ablation, Conventional EAM-guided catheter ablation
- Where
- China
- Volunteers
- 526 people
- Sponsor
- China National Center for Cardiovascular Diseases
Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis
Low-dose Colchicine for Thromboprophylaxis After Transcatheter Aortic Valve Replacement
This prospective, randomized, open-label study aims to evaluate the efficacy and safety of low-dose colchicine (0.5 mg daily) in reducing transcatheter heart valve (THV) thrombosis in patients after TAVR.
- Conditions
- Transcatheter Aortic Valve Replacement, Transcatheter Heart Valve Thrombosis, Anti-inflammatory Therapy
- Trial name
- LoDoCo-TAVR (NCT07411768)
- Testing
- Colchicine, Standard Care
- Where
- China
- Volunteers
- 116 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome
Early Initiation of Tafolecimab for Patients With Acute Coronary Syndromeundergoing Percutaneous Coronary Intervention in Chinese Population
For patients with ACS undergoing PCI, intensive lipid-lowering including PCSK9 monoclonal antibody should be started as soon as possible, that is, lower LDL-C level should be achieved as soon as possible.
- Conditions
- Acute Coronary Syndrome, Non ST Segment Elevation Acute Coronary Syndrome, Lipid Lowering, Vascular Inflammation
- Trial name
- NCT06096909
- Testing
- Tafolecimab, Cholesterol Absorption Inhibitor, Statin
- Where
- 2 sites in China
- Volunteers
- 3,684 people
- Sponsor
- China National Center for Cardiovascular Diseases
Paroxysmal Atrial Fibrillation
Conscious Sedation Versus General Anesthesia for Pulsed Field Ablation in Paroxysmal Atrial Fibrillation
This prospective, multicenter, randomized, controlled, noninferiority trial will compare local anesthesia with conscious sedation and general anesthesia in patients undergoing pulsed field ablation for paroxysmal atrial…
- Trial name
- PULSE-SED (NCT07877519)
- Testing
- Local Anesthesia With Conscious Sedation, General Anesthesia, VARIPULSE Pulsed Field Ablation System
- Where
- China
- Volunteers
- 390 people
- Sponsor
- China National Center for Cardiovascular Diseases
Completed, with results posted
All 1Ventricular Mural Thrombosis
An Exploratory stuDy of effectIveneSs and Safety of rivarOxaban in Patients With Left VEntricular Thrombus (R-DISSOLVE)
To study the effect of rivaroxaban anticoagulant therapy for 12 weeks in patients with left ventricular mural thrombus by contrast echocardiography before and after treatment, so as to provide basis and foundation for further…
- Trial name
- R-DISSOLVE (NCT04970381)
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 75 people
- Sponsor
- China National Center for Cardiovascular Diseases