Drug or intervention
Paracetamol Clinical Trials
Studies that test Paracetamol, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 422Labor Pain
Analgesic Efficacy and Obstetric Effects of Tramadol, Paracetamol and Placebo in Active Labor
This randomized, double-blind, placebo-controlled trial aims to compare the analgesic efficacy and obstetric effects of tramadol (100 mg IV) versus paracetamol (1 g IV) versus placebo (saline solution) in nulliparous women during…
- Trial name
- TRAMPA (NCT07440069)
- Testing
- Tramadol Hydrochloride, Paracetamol (acetaminophen)
- Where
- 2 sites in Honduras
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Honduras
Hematologic Test, Agranulocytosis
Hematological Safety of Dipyrone Versus Paracetamol After Dental Extractions
The goal of this clinical trial is to compare the safety of dipyrone and paracetamol when used for pain relief after dental extractions in adults.
- Conditions
- Hematologic Test, Agranulocytosis, Side Effects, Blood Pressure Monitoring
- Trial name
- NCT07918040
- Testing
- Dipyrone administration, Paracetamol (drug), blood sampling
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Matheus Furtado de Carvalho
Cancer Pain, Orofacial Pain
Effectiveness of Phenotype-based Pain Management Guidelines for Head and Neck Cancer Related Pain: a Pilot Study
The goal of this clinical trial is to find out whether phenotype-based pain management guidelines can effectively and safely reduce head and neck cancer-related pain in adults with head and neck cancer who have not yet started…
- Conditions
- Cancer Pain, Orofacial Pain, Head and Neck Cancer, Head and Neck (HNSCC)
- Trial name
- NCT07919444
- Testing
- myofascial pain, Orofacial bone pain, Orofacial Mucosal Pain
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Triple-Negative Breast Cancer
Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)
This is a randomized, open-label study comparing the efficacy and safety of adjuvant sacituzumab tirumotecan (MK-2870) in combination with pembrolizumab compared to treatment of physician's choice (TPC) in participants with…
- Trial name
- NCT06393374
- Testing
- Pembrolizumab, Sacituzumab tirumotecan, Capecitabine
- Where
- 314 sites in United States, Argentina and 29 more
- Volunteers
- 1,530 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Postsurgical Pain, Chronic Post Cancer Surgery Pain
Phenotype-based Model for Managing Chronic Post-treatment Pain Among Head and Neck Cancer Survivors: a Pilot Study
The goal of this clinical trial is to find out whether a phenotype-based pain management approach can reduce chronic pain in adults (18 years and older) who have completed curative treatment for head and neck cancer and continue…
- Conditions
- Chronic Postsurgical Pain, Chronic Post Cancer Surgery Pain, Chronic Post Operative Pain, Radiation Effects
- Trial name
- NCT07919457
- Testing
- Myofascial Pain, Orofacial Bone Pain, Neuralgia Pain
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Lymphoma, Large B-Cell, Diffuse, Diffuse Large B-Cell Lymphoma
A Clinical Trial of MK-1045 With Zilovertamab Vedotin in Participants With Diffuse Large B-cell Lymphoma (MK-1045-010)
Researchers are looking for new ways to treat relapsed or refractory, diffuse large B-cell lymphoma (R/R DLBCL). Relapsed means the cancer came back after treatment.
- Trial name
- WaveSpan-010 (NCT07917754)
- Testing
- MK-1045, Zilovertamab vedotin, Rituximab
- Volunteers
- 470 people
- Sponsor
- Merck Sharp & Dohme LLC
Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma
A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)
Researchers are looking for new ways to treat people with B-cell cancers. In this trial, researchers will look at chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL).
- Conditions
- Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma, Hematologic Malignancies
- Trial name
- NCT07709000
- Testing
- MK-1045, Acetaminophen (or similar antipyretic), Diphenhydramine (or similar antihistamine)
- Where
- 7 sites in Colombia, Israel
- Volunteers
- 60 people
- Sponsor
- Merck Sharp & Dohme LLC
Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
This phase III trial tests if gabapentin can prevent the need for opiate pain medication for mouth sores (oral mucositis) in patients undergoing treatment with chemotherapy and radiation for squamous cell carcinoma of the head…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Stage I Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8, Stage II Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8, Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Trial name
- HOPE (NCT06992427)
- Testing
- Gabapentin, Chemotheraphy, Radiation Therapy
- Where
- 216 sites in United States
- Volunteers
- 228 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Inguinal Hernia, Postoperative Pain
Lumbar ESP Block Versus TAP Block for Postoperative Pain Control in Children Undergoing Open Inguinal Hernia Repair
This study evaluates two ultrasound-guided nerve block techniques-Erector Spinae Plane Block (ESPB) and Transversus Abdominis Plane (TAP) block-for pain relief in children undergoing elective open inguinal hernia repair.
- Trial name
- NCT07916233
- Testing
- Ultrasound-guided Lumbar Erector Spinae Plane Block (ESPB), Ultrasound-guided Transversus Abdominis Plane (TAP) Block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Beni-Suef University
Multimodal Analgesia, Tramadol
Tramadol Versus Morphine for Postoperative Pain Relief Following Laparoscopic Abdominal Surgery
Tramadol is commonly used postoperatively due to its ease of administration, but it carries several risks, including interindividual variability, drug interactions, neuropsychiatric risks in elderly patients, and long-term…
- Conditions
- Multimodal Analgesia, Tramadol, Enhanced Recovery After Surgery, Opioid and Postoperative Pain
- Trial name
- TRAMORNOT (NCT07914335)
- Testing
- Anesthesia induction, Anesthesia maintenance, Multimodal analgesia
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Completed, with results posted
All 434Pain
A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy
The purpose of this study is to evaluate effectiveness of a fixed combination of acetaminophen/naproxen sodium compared with placebo for reduction of pain when administered as multiple doses over a 48-hour period.
- Trial name
- NCT05868122
- Testing
- Acetaminophen/Naproxen Sodium Fixed Combination
- Where
- 4 sites in United States
- Volunteers
- 143 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Pain
A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental Pain
The purpose of this study is to evaluate how well a fixed combination of acetaminophen/naproxen sodium relieves postoperative dental pain compared with acetaminophen, naproxen sodium and placebo.
- Trial name
- NCT05761574
- Testing
- Acetaminophen/Naproxen Sodium Fixed Combination, Naproxen Sodium, Acetaminophen
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Postoperative Pain, Abdominoplasty Surgery
Cohort 2 (Abdominoplasty) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)
Cohort 2 (subjects undergoing abdominoplasty) of a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing different surgical procedures See also…
- Conditions
- Postoperative Pain, Abdominoplasty Surgery, Multimodal Analgesia
- Trial name
- AMAZE (NCT06109428)
- Testing
- MMA regimen, ZYNRELEF kit components for administration, HTX-011
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Heron Therapeutics
Postoperative Pain
PK and Safety After C-Section
The main goal of the study was to measure the amount of the active ingredients and other components of HTX-011 in plasma and expressed breast milk over time following postpartum administration in women undergoing a planned…
- Trial name
- NCT03955211
- Testing
- HTX-011, ZYNRELEF kit components for administration, MMA regimen
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Heron Therapeutics
Postoperative Pain, Total Shoulder Arthroplasty
Cohort 1 (TSA) of: A Multi-surgery Assessment of ZYNRELEF (HTX-011)
Cohort 1 (subjects undergoing total shoulder arthroplasty, TSA) of a Phase 4, randomized, blinded, active-controlled, multicohort study to evaluate HTX-011 compared with bupivacaine HCl in subjects undergoing different surgical…
- Conditions
- Postoperative Pain, Total Shoulder Arthroplasty, Multimodal Analgesia
- Trial name
- AMAZE (NCT06109415)
- Testing
- HTX-011, Bupivacaine Hydrochloride, MMA regimen
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Heron Therapeutics