Drug or intervention
Oxytocin Clinical Trials
Studies that test Oxytocin, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 120Arginine Vasopressin Deficiency, Oxytocin Deficiency
Identifying Oxytocin Deficiency in Pediatric Patients With Pituitary Disease
An open-labeled, interventional pilot trial, 10 youth with AVP-D and 10 PD matched for age, sex, and BMI will be recruited from Pediatric Endocrinology and Neuroendocrinology at Massachusetts General Hospital and in the…
- Conditions
- Arginine Vasopressin Deficiency, Oxytocin Deficiency, Pediatric Disease, Hypopituitarism
- Trial name
- Pedi-EVOLVE (NCT07568509)
- Testing
- Norethindrone Acetate-Ethinyl Estradiol
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Vasopressin Deficiency
Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency
This is a randomized, double-blind, placebo-controlled crossover pilot study of single-dose intranasal oxytocin (6 IU and 24 IU) vs.
- Trial name
- NCT04789148
- Testing
- Intranasal Oxytocin (IN-OXT) 6 IU single dose, Intranasal Oxytocin (IN-OXT) 6 IU repeat dose, Intranasal Oxytocin (IN-OXT) 24 IU single dose
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Elizabeth Austen Lawson
Total Hip Arthroplasty
Efficacy of Intravenous Oxytocin to Speed Recovery After THA
The purpose of this study is to test whether perioperative intravenous (IV) oxytocin compared to placebo results in faster recovery in disability as measured by daily steps over 56 days after Total Hip Arthroplasty (THA).
- Trial name
- NCT07430228
- Testing
- intravenous administration of oxytocin
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Pituitary Surgery
Evaluating Intranasal Oxytocin (TNX-1900) for Pain Relief and Recovery After Pituitary Surgery
This study is testing whether oxytocin can help lessen pain by changing how people process emotions and social experiences. The goal is to better understand how the brain links emotions, relationships, and pain, and whether this…
- Trial name
- NCT07730294
- Testing
- Oxytocin (Low dose), Oxytocin (High dose)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Yale University
Labor Analgesia, Labor Pain
Effect of Dural Puncture Epidural Analgesia on Oxytocin in Early vs Late Labor
Oxytocin is a key hormone that regulates uterine contractions during labor. Dural Puncture Epidural Analgesia (DPEA) is a modern technique for labor pain relief that provides faster onset and more reliable analgesia than standard…
- Conditions
- Labor Analgesia, Labor Pain, Oxytocin
- Trial name
- DPEA-OXY (NCT07873814)
- Testing
- Dural Puncture Epidural Analgesia (DPEA)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Spine, Low Back Pain
Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain
The goal of this randomized cross-over mechanistic trial is to compare pre- and post-level cortisol and oxytocin changes in patients with chronic spine pain who receive either a hand's on (massage) or a hand's off (talk-based)…
- Conditions
- Spine, Low Back Pain, Neck Pain
- Trial name
- COTHA (NCT06987786)
- Testing
- Massage, Talk-based therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Autism
Interactive Massage Intervention in Toddlers With Autism Spectrum Disorder
This randomized controlled trial aims to evaluate the efficacy of a 3-month maternal interactive massage intervention in toddlers aged 18-24 months with autism spectrum disorder (ASD).
- Trial name
- IMI-ASD (NCT07876245)
- Testing
- Maternal Interactive Massage, Behavioral
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Breastfeeding, Mother-Infant Bonding
Effects of Maternal and Infant Massage on Breastfeeding and Mother-Infant Bonding
This study aims to evaluate the effects of different massage techniques applied to mothers and infants on breastfeeding parameters and mother-infant bonding during the postpartum period.
- Conditions
- Breastfeeding, Mother-Infant Bonding, Lactation
- Trial name
- MIM-BOND (NCT07867054)
- Testing
- Infant Massage, Oxytocin Massage, Infant Massage and Oxytocin Massage
- Volunteers
- 136 people
- Sponsor
- Istanbul University - Cerrahpasa
Labor and Delivery
Effect of a Vertical Birthing Chair on Labor
The goal of this randomized clinical trial is to evaluate whether the use of a vertical birthing chair during the active second stage of labor improves fetal head descent and rotation.
- Trial name
- NCT07874243
- Testing
- Using a vertical birthing chair during the active second stage of labor
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Kartal City Hospital
Postpartum Hemorrhage, Uterine Atony
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Background: Carbetocin is an established single-dose uterotonic agent for postpartum hemorrhage prophylaxis at elective cesarean delivery.
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Cesarean Section, Blood Loss, Surgical
- Trial name
- CARBOXY-RCT (NCT07636421)
- Testing
- Carbetocin, Oxytocin
- Where
- Saudi Arabia
- Volunteers
- 332 people
- Sponsor
- Mansoura University
Completed, with results posted
All 141Social Phobia
Social Safety Learning in the Brain Oxytocin System
The investigators are conducting this research study to examine whether oxytocin enhances social safety learning (learning safety through the experience of another individual) in people with social anxiety disorder (SAD) compared…
- Trial name
- NCT05968651
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Washington
PTSD
Oxytocin to Treat PTSD
Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition that disproportionately affects Veterans. Prolonged Exposure (PE) therapy is a "gold standard" treatment for PTSD.
- Trial name
- NCT04228289
- Testing
- Oxytocin
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- VA Office of Research and Development
Knee Osteoarthritis, Osteoarthritis
Understanding Cognition, Oxytocin & Pain in Elders
Osteoarthritis (OA) represents a significant cause of disability worldwide and the knee is the most commonly affected joint. Oxytocin (OT) is a mediator of endogenous analgesia in animal and human studies.
- Trial name
- UCOPE (NCT03878589)
- Testing
- Oxytocin (OT)
- Where
- 2 sites in United States
- Volunteers
- 83 people
- Sponsor
- University of Florida
Pregnancy Complications
Carbetocin Myocardium Trial 2014 Part 2
Carbetocin has been in clinical use in EU for some years and the efficacy is documented in several RCTs. Circulatory adverse events leading to death has been reported after intravenous injection of oxytocin.
- Trial name
- CMT2014/2 (NCT03899961)
- Testing
- Oxytocin, Carbetocin
- Where
- 2 sites in Norway
- Volunteers
- 240 people
- Sponsor
- Oslo University Hospital
Labor Long
Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor
The goal of this clinical trial is to compare oxytocin infusion rates for induction and augmentation of labor in nulliparous women.
- Trial name
- NCT05782816
- Testing
- Oxytocin (Low dose), Oxytocin (High dose)
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- The University of Texas Medical Branch, Galveston