Drug or intervention
Misoprostol Clinical Trials
Studies that test Misoprostol, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 42Postmenopausal Women, Intrauterine Diseases
Office Hysteroscopy in Postmenopausal Women: A Randomized Trial of Cervical Preparation Strategies
The goal of this randomized controlled trial is to evaluate the effectiveness of different cervical preparation strategies before office hysteroscopy in postmenopausal women undergoing evaluation for intrauterine pathology.
- Conditions
- Postmenopausal Women, Intrauterine Diseases, Endometrial Pathology, Postmenopausal Bleeding
- Trial name
- NCT07697781
- Testing
- No Cervical Preparation, Misoprostol ( Cytotec) 200 microgram a tablet, Vaginal Estrogen (7-Day Regimen)
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Faculty of Medicine of Tunis
Medical Abortion
'No-test' Tele-abortion: a Multi-centre Randomised Controlled Trial
Brief Summary The goal of this clinical trial is to learn whether a no-test telemedicine medical abortion model can provide abortion care that is as effective and safe as standard clinic-based medical abortion care among women…
- Trial name
- OPTIMISE (NCT07868991)
- Testing
- no-test medical abortion, Standard Care (in control arm)
- Where
- 10 sites in Sweden
- Volunteers
- 978 people
- Sponsor
- Karolinska Institutet
Early Pregnancy Loss
Optimal Time Interval Between Mifepristone and Misoprostol Administration for Early Pregnancy Loss
A prospective cohort study to explore the optimal time interval between mifepristone and misoprostol administration for medical management of early pregnancy loss.
- Trial name
- TIME (NCT07506512)
- Testing
- 200mg mifepristone and 800mg misoprostol
- Volunteers
- 1,000 people
- Sponsor
- University of Pennsylvania
Pregnancy, Cervical Ripening
Improving the Childbirth Experience for Women Who Have Undergone Cervical Ripening by Involving Them in the Choice of Ripening Technique
This is a prospective, single-centre, quasi-experimental before-and-after study. Women due to give birth at the participating centre will be informed about the study during their 9th-month antenatal appointment.
- Conditions
- Pregnancy, Cervical Ripening, Childbirth
- Trial name
- AVAPAM (NCT07855146)
- Testing
- The patient will be offered the various possible methods of inducing cervical ripening, and the choice of method will be left to her, Standard Care (in control arm)
- Where
- France
- Volunteers
- 204 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Menstrual Regulation, Menstrual Health Intervention
Period Pills for Menstrual Regulation: A New Reproductive Health Option
The Period Pills Study is a prospective observational study among people who decide to use a combination of mifepristone and misoprostol for menstrual regulation.
- Trial name
- Period Pills (NCT07671989)
- Testing
- Mifepristone + Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cervical Cancers
Use Misoprostol to Optimize Prevention of Cervical Cancer
This is a double-blind randomized controlled trial of 420 non-pregnant women undergoing cancer screening by visual inspection with acetic acid (VIA) who have Type 3 transformation zone (TZ) and randomized to receive either…
- Trial name
- MISOPCx (NCT06669533)
- Testing
- Misoprostol
- Where
- Cameroon
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Nulliparous Women Who Scheduled for Labor Induction, Pregnancy
Ripening Approaches for Prompt Induction and Delivery - Sequential Versus Concurrent Dilapan-S and Misoprostol to Achieve Vaginal Delivery (RAPID-DS)
The purpose of this study is to compare the effectiveness of sequential versus combined multimodal cervical ripening strategies to achieve vaginal delivery within 24 hours among nulliparous patients with singleton, vertex…
- Trial name
- RAPID-DS (NCT07717502)
- Testing
- Sequential Cervical Ripening, Inpatient Combined Cervical Ripening
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- Ochsner Health System
Abortion Induced Complicated, Abortion
Second Trimester Abortion With Letrozole and Misoprostol Compared to Misoprostol Alone
Termination of Second trimester Abortion with Letrozole and Misoprostol Compared to Misoprostol Alone
- Trial name
- NCT07767435
- Testing
- · Misoprostol + letrozole, misoprostol alone
- Volunteers
- 80 people
- Sponsor
- Sohag University
Letrozole
The Value of Pretreatment With Letrozole on Induction Time of Medical Evacuation With Misoprostol in Cases of Missed Abortion
The aim is to evaluate the effect of letrozole pretreatment on the induction time during medical evacuation using misoprostol in women diagnosed with missed abortion, and to compare its efficacy and safety to misoprostol alone.
- Trial name
- NCT07753655
- Testing
- Intervention Group: letrozole followed by misoprostol, Control Group: misoprostol only
- Volunteers
- 74 people
- Sponsor
- Cairo University
Postpartum Hemorrhage, Uterine Atony
Oxytocin Bolus Versus Infusion in High-Risk Patients Undergoing Elective Cesarean Section (INBOX-HR)
The goal of this randomized, double-blind clinical trial is to learn if Oxytocin is most effective at achieving adequate uterine tone (important for preventing postpartum hemorrhage) when administered as a bolus or an infusion in…
- Conditions
- Postpartum Hemorrhage, Uterine Atony, Uterine Atony With Hemorrhage, Elective Cesarean Section
- Trial name
- INBOX-HR (NCT07688512)
- Testing
- Oxytocin Bolus or Oxytocin Infusion
- Volunteers
- 180 people
- Sponsor
- Stony Brook University
Completed, with results posted
All 48Abortion, Second Trimester, PPROM
Simultaneous Mifepristone and Misoprostol Versus Misoprostol Alone for Induction of Labor of Nonviable Second Trimester Pregnancy: a Pilot Randomized Controlled Trial
When time allows, administration of mifepristone prior to second trimester induction of labor decreases total labor time. However, in the setting of many pregnancy complications, decreasing time from diagnosis of nonviable…
- Conditions
- Abortion, Second Trimester, PPROM, Rupture, Spontaneous, Fetal Demise
- Trial name
- MIST (NCT05322252)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Myomectomy; Surgical Blood Loss
Rectal Misoprostol as a Hemostatic Agent During Abdominal Myomectomy
Purpose is to identify if misoprostol in addition to local vasopressin decreases blood loss when compared to vasopressin alone, which is our current practice at this time.
- Trial name
- NCT03064568
- Testing
- Misoprostol 200Mcg Tab
- Where
- 3 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Abortion Early, Pregnancy Related
Mail Order Mifepristone Study
This study aims to evaluate the feasibility, acceptability, and effectiveness of dispensing mifepristone via a mail-order pharmacy.
- Trial name
- NCT03913104
- Testing
- Mifepristone
- Where
- 11 sites in United States
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Daniel Grossman, MD
Induced Vaginal Delivery
Mifepristone for Labor Induction
The purpose of this trial is to explore mifepristone as an option for induction of labor at term by evaluating the efficacy of mifepristone use for cervical preparation.
- Trial name
- MiLI (NCT05097326)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Labor Onset and Length Abnormalities, Induced; Birth
Comparison of Misoprostol Ripening Efficacy With Dilapan
The purpose of this study is to find out if Dilapan works as well as Misoprostol for preparing the mouth of the uterus (cervix) for inducing labor in women who need to undergo this procedure.
- Trial name
- COMRED (NCT03670836)
- Testing
- Dilapan, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Columbia University