Drug or intervention
Hydrocortisone Clinical Trials
Studies that test Hydrocortisone, alone, with other treatments or as the comparison.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 263Survivors of Childhood Cancer, Acute Lymphoblastic Leukemia, Childhood
Feasibility and Acceptability of Remote Saliva Collection
The purpose of this study is to evaluate the practicality and acceptability of collecting biological samples and health information from childhood survivors of acute lymphoblastic leukemia (ALL) and their siblings.
- Trial name
- NCT07884474
- Testing
- Salivary Cortisol Collection, Blood Biomarker Collection, Hair Cortisol Collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Psychological Distress, Insomnia
Clinical Trial for Acupuncture in Adolescents With Psychological Distress and Insomnia
This is an assessor-blinded, randomized, MAS-controlled trial. A total of 148 adolescents aged 15-22 years experiencing mild to moderate anxiety or depressive symptoms will be recruited.
- Trial name
- NCT06638450
- Testing
- Dense Cranial Electroacupuncture Stimulation plus Body Acupuncture (DCEAS+BA), Minimal Acupuncture Stimulation (MAS)
- Where
- Hong Kong
- Volunteers
- 148 people
- Sponsor
- The University of Hong Kong
Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8
A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab
This phase III trial compares the effect of adding immunotherapy (brentuximab vedotin and nivolumab) to standard treatment (chemotherapy with or without radiation) to the standard treatment alone in improving survival in patients…
- Trial name
- NCT05675410
- Testing
- Biospecimen Collection, Bleomycin Sulfate, Brentuximab Vedotin
- Where
- 419 sites in United States, Canada and 1 more
- Volunteers
- 1,875 people
- Sponsor
- National Cancer Institute (NCI)
Prostate Cancer Metastatic
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall…
- Trial name
- OMAHA-003 (NCT06136624)
- Testing
- Opevesostat, Abiraterone acetate, Enzalutamide
- Where
- 288 sites in United States, Argentina and 34 more
- Volunteers
- 1,310 people
- Sponsor
- Merck Sharp & Dohme LLC
Pain, Anxiety
The Effect of ShotBlocker on Symptoms of Pain, Anxiety, and Cortisol Hormone Levels
The aim of this study is to evaluate the effect of Shotblocker, administered during lumbar puncture, on patients' pain levels, anxiety levels, and cortisol levels (a physiological stress indicator).
- Trial name
- NCT07880496
- Testing
- Intervention Group, Control
- Volunteers
- 68 people
- Sponsor
- Ataturk University
Chronic Pain, Neuropathic Pain
Transcranial Direct Current Stimulation for Chemotherapy-Related Chronic Pain in Cancer Survivors
The goal of this clinical trial is to learn if transcranial direct current stimulation (tDCS) combined with a working-memory task can treat chronic pain and related emotional and cognitive problems after chemotherapy in adult…
- Conditions
- Chronic Pain, Neuropathic Pain, Cancer Survivors, Anxiety
- Trial name
- ONCOSTIM (NCT07912775)
- Testing
- Active tDCS with Sternberg task
- Where
- 2 sites in Spain
- Volunteers
- 60 people
- Sponsor
- Instituto de investigación e innovación biomédica de Cádiz
Chronic Insomnia
Effects of Connective Tissue Massage in Patients With Chronic Insomnia
This randomized controlled trial will investigate the effects of connective tissue massage on insomnia severity, objective and subjective sleep outcomes, and stress- and autonomic-related biomarkers in adults with chronic…
- Trial name
- NCT07770945
- Testing
- Connective Tissue Massage, Sleep Hygiene Education
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Saglik Bilimleri Universitesi
CNS Embryonal Tumor, CNS, Medulloblastoma
Pilot Study of IT Topotecan and Maintenance Chemotherapy for HR-EBTs in Children < 6 Years, Post Consolidation
Pilot study to determine feasibility of adding intrathecal chemotherapy and maintenance therapy after high dose chemotherapy for treatment of newly diagnosed HR-EBTs in patients less than 6 years of age.
- Conditions
- CNS Embryonal Tumor, CNS, Medulloblastoma, Atypical Teratoid Rhabdoid Tumor, Medulloblastoma, Childhood
- Trial name
- NCT06942039
- Testing
- Cytarabine IT, hydrocortisone, Cisplatin
- Where
- 13 sites in Canada
- Volunteers
- 15 people
- Sponsor
- C17 Council
Hemorrhoidal Disease
A Three-Arm, Randomized, Placebo-Controlled, Double-Blind Phase 2 Study to Evaluate the Safety and Efficacy of Two Dosage Regimens of a Novel Hydrocortisone Acetate Suppository Formulation Administered With a Proprietary Suppository Applicator in Subjects With Hemorrhoidal Disease
The goal of this clinical trial is to evaluate the efficacy of two dosage regimens of hydrocortisone acetate suppository administered with a proprietary suppository applicator (Study Drug) compared to placebo in the treatment of…
- Trial name
- NCT07909291
- Testing
- hydrocortisone acetate 50 mg, hydrocortisone acetate 75 mg, proprietary suppository applicator
- Volunteers
- 78 people
- Sponsor
- Cristcot LLC
Stress, Anxiety
Psychological and Physiological Effects of Three-Minute Breathing Space Meditation in UPM Postgraduate Students
Postgraduate students often experience psychological distress linked to academic demands, deadlines, research uncertainty, and financial or social pressures, and international students may face additional adjustment challenges.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT07911020
- Testing
- Three-Minute Breathing Space Meditation, Neutral Audio Attention-Control Activity
- Where
- Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- ZIRUI LIU
Completed, with results posted
All 171Congenital Adrenal Hyperplasia
Comparison of Chronocort Versus Standard Hydrocortisone Replacement Therapy in Participants Aged 16 Years and Over With Congenital Adrenal Hyperplasia
This study is a randomized, double-blind, active-controlled, phase III study of Chronocort® compared with immediate-release hydrocortisone replacement therapy in participants aged 16 years and over with Congenital Adrenal…
- Trial name
- CONnECT (NCT05063994)
- Testing
- Chronocort, Cortef
- Where
- 21 sites in United States, France and 1 more
- Volunteers
- 55 people
- Sponsor
- Neurocrine UK Limited
Healthy Subjects
Comparison of Pharmacokinetics of Infacort® Versus Immediate-release Hydrocortisone
This was a single centre, open-label, randomised, 5-way crossover study.
- Trial name
- NCT02777268
- Testing
- Infacort, Hydrocortisone
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Congenital Adrenal Hyperplasia
A Study of the Efficacy, Safety and Tolerability of Chronocort in Treating CAH
Subjects completing study DIUR-005 and those who have already completed study DIUR-003 will be offered the opportunity either to continue Chronocort® therapy or to switch from their current glucocorticoid therapy to Chronocort®…
- Trial name
- NCT03062280
- Testing
- Hydrocortisone
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Neurocrine UK Limited
Endocrine Disease, Adrenal Insufficiency
Pilot Study to Characterize and Examine the Pharmacokinetics and Efficacy of Chronocort® in Adults With CAH
The purpose of this study is to gather safety and effectiveness information about a new formulation of Hydrocortisone (Chronocort®) used to treat patients with a disease called congenital adrenal hyperplasia (CAH).
- Conditions
- Endocrine Disease, Adrenal Insufficiency, Congenital Adrenal Hyperplasia
- Trial name
- NCT01735617
- Testing
- Hydrocortisone Modified Release Capsules
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Neurocrine UK Limited
Adrenal Insufficiency
Treatment of Adrenal Insufficiency in Children
The study will be conducted in a total of 24 subjects before their 6th birthday, requiring replacement therapy for adrenal insufficiency due to either CAH, primary adrenal failure or hypopituitarism.
- Trial name
- NCT02720952
- Testing
- Infacort®
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Neurocrine UK Limited