Condition
Spinal Cord Injuries Clinical Trials
Studies of spinal cord injuries, matched by condition name and medical subject headings. Start with those open to enrolment.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 523Cerebral Palsy, Muscular Dystrophy
Evaluating Long-term Use of a Pediatric Robotic Exoskeleton (P.REX/Agilik) to Improve Gait in Children With Movement Disorders
Background: People with cerebral palsy, spina bifida, muscular dystrophy, or spinal cord injury often have muscle weakness and problems controlling how their legs move. This can affect how they walk.
- Conditions
- Cerebral Palsy, Muscular Dystrophy, Spina Bifida, Incomplete Spinal Cord Injury
- Trial name
- NCT05726591
- Testing
- EA-KAFO
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Spinal Cord Injury, Pressure Injury
Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic
Spinal cord injury (SCI) is a permanent condition affecting every aspect of life including health, daily activities, and participation and quality of life.
- Trial name
- CAPP-FIT (NCT06529094)
- Testing
- Provider training, CAPP-FIT intervention with RA facilitation, CAPP-FIT implementation during maintenance phase
- Where
- 8 sites in United States
- Volunteers
- 808 people
- Sponsor
- VA Office of Research and Development
Brainstem Stroke, ALS
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Tablet-01)
People with brainstem stroke, advanced amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), or other disorders can become unable to move or speak despite being awake and alert.
- Conditions
- Brainstem Stroke, ALS, Tetraplegia, Spinal Cord Injuries
- Trial name
- BG-Tablet-01 (NCT06511934)
- Testing
- BrainGate Neural Interface System
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Leigh R. Hochberg, MD, PhD.
Spinal Cord Injury, Paralysis
A Neuroprosthesis for Seated Posture and Balance
The purpose of this study is to evaluate a surgically implanted functional electrical stimulation (FES) system to facilitate stability of the trunk and hips.
- Conditions
- Spinal Cord Injury, Paralysis, Tetraplegia, Paraplegia
- Trial name
- Trunk Protocol (NCT01474148)
- Testing
- IRS-8 (8-Channel implanted stimulator-telemeter)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Tetraplegia/Tetraparesis
Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia
The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities…
- Trial name
- SCIMS Main (NCT05423600)
- Testing
- BES + TS
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University
Spinal Cord Injuries (SCI)
AI-Guided Multi-Electrode Transcutaneous Spinal Cord Stimulation for Gait Rehabilitation in People With Spinal Cord Injury or Stroke
The goal of this clinical trial is to investigate whether personalized multi-electrode transcutaneous spinal cord stimulation (tSCS), guided by machine learning (ML) and combined with gait training, can improve walking function…
- Trial name
- NCT07895888
- Testing
- Single-Electrode Tonic tSCS, Multi-Electrode Spatiotemporal tSCS
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo General Hospital
Spinal Cord Injury, Spasticity
Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury
Spasticity is a common consequence of spinal cord injury and can have a profound impact on quality of life. The goal of this study is to learn if an intervention called focused extracorporeal shockwave therapy can enhance the…
- Trial name
- NCT07894991
- Testing
- Focused extracorporeal shockwave therapy, Botulinum toxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries (SCI)
Functional Electrical Stimulation Plus High Intensity Interval Training at Home
People living with SCI may experience loss of sensation, movement and regular body function. One way to address these impairments is activity-based therapy (ABT), which includes movement-based activities that promote the…
- Trial name
- NCT07773974
- Testing
- FES+HIIT@Home
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University Health Network, Toronto
Spinal Cord Injuries, Cervical Spinal Cord Injury
Augmenting Upper Limb Function and Functional Neuroplasticity Using Epidural Stimulation of the Cervical Spinal Cord
This study will test whether spinal stimulation combined with rehabilitation can improve arm and hand function in people with tetraplegia after spinal cord injury. Tetraplegia causes weakness or paralysis in the arms and legs.
- Conditions
- Spinal Cord Injuries, Cervical Spinal Cord Injury, Spinal Cord Injury
- Trial name
- NCT06225245
- Testing
- Epidural Spinal Stimulation (ESS), Upper extremity rehabilitation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The Methodist Hospital Research Institute
Spinal Cord Injury
Transcutaneous Spinal Cord Stimulation for Neurorehabilitation After Spinal Cord Injury
This pilot controlled study aims to evaluate the clinical and instrumental effects and feasibility of transcutaneous cervical spinal cord stimulation (tSCS) combined with conventional rehabilitation in adults with spinal cord…
- Trial name
- NEUROSTIM-SCI (NCT07893470)
- Testing
- ExaStim® Transcutaneous Spinal Cord Stimulation, Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ernesto Losavio
Completed, with results posted
All 242Spine Disease, Spinal Stenosis
CEUS For Intraoperative Spinal Cord Injury
Spinal cord injury following posterior decompression in patients suffering from chronic, cervicothoracic spinal cord compression is a known complication with multiple etiologies.
- Conditions
- Spine Disease, Spinal Stenosis, Spinal Injury, Spinal Cord Diseases
- Trial name
- NCT05530798
- Testing
- Definity Perflutren Lipid Microsphere Ultrasound Contrast
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical University of South Carolina
Pressure Ulcer
CMAP Refinement for Pressure Injury Prevention
For Veterans with spinal cord injury who use a wheelchair, pressure injuries related to sitting are a significant daily threat to well-being.
- Trial name
- NCT04309864
- Testing
- Use of CMAP app for education (in-hospital), Use of CMAP app (in-home)
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Spinal Cord Injury Cervical
Neuromodulation After Spinal Cord Injury to Improve Limb Function
The University at Buffalo (UB) Department of Rehabilitation Sciences is looking for adult volunteers with and without spinal cord injuries for a study on hand movement.
- Trial name
- NCT06815601
- Testing
- rTMS, Motor training
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Spinal Cord Injury
The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury
This study will examine the relationship between circulating irisin and bone health individuals with spinal cord injury. Additionally, this study seeks to examine the influence of muscle fiber type on circulating irisin and…
- Trial name
- IBSCI (NCT05319522)
- Testing
- Acute Exercise
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Neurogenic Bladder Dysfunction
Chronic Electrical Stimulation to Reduce Bladder Hyperreflexia
Bladder spasms after spinal cord injury (SCI) can result in incontinence, urinary tract infections, kidney damage, trigger dangerous increases in blood pressure and decrease independence and quality of life.
- Trial name
- NCT03472599
- Testing
- Genital Nerve Stimulation
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- VA Office of Research and Development