Condition
Pain, Postoperative Clinical Trials
Studies of pain, postoperative, matched by condition name and medical subject headings. Start with those open to enrolment.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 1,413Pain, Postoperative
Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children
The primary objective of this study is to determine if the peri and post operative use of gabapentin in children reduces the need for narcotics after thoracic surgery.
- Trial name
- NCT04724252
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Davis
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction
The goal of this clinical trial is to learn whether taking oral tranexamic acid (TXA) for one week after anterior cruciate ligament (ACL) reconstruction improves recovery in adolescents and young adults aged 14 to 25 years.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Pain, Postoperative
- Trial name
- NCT07880743
- Testing
- Tranexamic Acid
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- Dave Bernholt
Postoperative Pain
ESP Blocks for Posterior Spinal Fusion
This prospective randomized double-blind study evaluates the efficacy of erector spinae plane (ESP) blocks on postoperative pain in patients undergoing cervical or lumbar posterior spinal fusion.
- Trial name
- NCT07228039
- Testing
- ESP Block with Bupivacaine, ESP Block with Bupivacaine + Liposomal Bupivacaine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Wound Healing, Alveolitis of Jaw
Effect of Curcumin Topical Spray on Wound Healing After Tooth Extraction
This randomized, single-blind, controlled clinical trial aims to evaluate the effects of a topical curcumin spray on post-extraction wound healing and postoperative symptoms in adults undergoing first molar extraction.
- Conditions
- Wound Healing, Alveolitis of Jaw, Tooth Extraction, Curcumin
- Trial name
- NCT07874789
- Testing
- Curcumin Topical Spray, Chlorhexidine Topical Spray
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Breast Cancer, Postoperative Pain
Comparison of Postoperative Analgesic Efficacy of Two Different Blocks in Modified Radical Mastectomy Surgery
Postoperative pain following modified radical mastectomy remains a significant clinical challenge and may delay recovery, impair patient comfort, and increase opioid consumption.
- Trial name
- mastectomy (NCT07737132)
- Testing
- Ultrasound-Guided Serratus Posterior Superior Intercostal Plane Block (SPSIPB), Ultrasound-Guided Serratus Anterior Plane Block (SAPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Cleft Lip, Cleft Palate +/- Lip
Comparative Study of Regional Nerve Blocks in Primary Cleft Palate Repair
This study will evaluate whether adding a suprazygomatic maxillary nerve block to the standard palatal nerve block improves pain control after cleft palate repair surgery in children.
- Conditions
- Cleft Lip, Cleft Palate +/- Lip, Pain Management, Wound Dehiscence, Surgical
- Trial name
- NCT07892963
- Testing
- Palatal Nerve Block, Suprazygomatic Maxillary Nerve Block
- Volunteers
- 144 people
- Sponsor
- Children's National Research Institute
Pain, Postoperative
Posterior Pericapsular Deep-gluteal Block
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after…
- Trial name
- NCT07891013
- Testing
- PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block, PPD (Posterior pericapsular deep gluteal) block
- Volunteers
- 60 people
- Sponsor
- Ankara Etlik City Hospital
Postoperative Pain After Total Knee Arthroplasty
Agreement Between Patient-Reported Pain, Observer-Rated Pain Behavior, and Analgesic Request After Total Knee Arthroplasty
The goal of this observational study is to learn how well patients' own pain ratings match what an observer sees and whether the patient asks for extra pain medicine after total knee replacement surgery.
- Trial name
- NCT07891221
- Volunteers
- 120 people
- Sponsor
- Gamze Kübra Zelyurt
Periapical Healing
Evaluation of Three Different Intra-canal Medicaments
Periapical lesions are the commonly occurring pathologic lesions that affect the periradicular tissues of the tooth . This lesion can be classified as granuloma, cystic, or abscess .The pathologic changes seen in some…
- Trial name
- NCT07892703
- Testing
- Metapaste Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Minia University
Completed, with results posted
All 753Knee Osteoarthritis
Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT
Each year, approximately 75,000 Canadians undergo knee replacement surgery, and up to 25% develop persistent post-surgical pain.
- Trial name
- NCT03825965
- Testing
- MPL-001 (CBD: THC 25:1)
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Pain, Pain, Postoperative
Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain
To develop and refine a technology based treatment protocol for preoperative education and training and postoperative care in children and adolescents undergoing surgery.
- Conditions
- Pain, Pain, Postoperative, Pain, Acute, Surgery
- Trial name
- NCT04943874
- Testing
- Technology Based Intervention Group 1, Technology Based Intervention Group 2
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Vanessa Olbrecht
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.
Pain, Postoperative, Narcotic Use
Bupivacaine for Post-operative Pain in Mohs
Mohs micrographic surgery (MMS) is regarded as the gold standard for the treatment of high-risk nonmelanoma skin cancer (NMSC). Pain after MMS peaks on the day of surgery and slowly decreases thereafter.
- Trial name
- NCT04362566
- Testing
- Bupivacaine
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Low Level Laser Therapy, Healthy
Effect of GaAlAs 940 Laser on Pain and Wound Healing After Free Gingival Graft
This randomized controlled clinical trial aims to evaluate the biomodulatory effects of a 940-nm GaAlAs diode laser on postoperative pain control and wound healing at the palatal donor site following free gingival graft…
- Conditions
- Low Level Laser Therapy, Healthy, Postoperative Pain Management, Wound Healing
- Trial name
- NCT07308912
- Testing
- 940 nm GaAlAs diode laser, palatal stent
- Where
- Vietnam
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City