Condition
Acute Pain Clinical Trials
Studies of acute pain, matched by condition name and medical subject headings. Start with those open to enrolment.
In numbers
Open to volunteers: recruiting, not yet recruiting or enrolling by invitation. Active adds studies under way that have stopped recruiting.
Open to volunteers
All 451Pain Management, Injection Pain Prevention
Testing the Timing and Application of Virtual Reality Distraction During Knee Injections in a VA Pain Clinic
The goal of this clinical trial is to learn whether virtual reality (VR) can be added to routine knee injection appointments at a VA outpatient pain clinic without slowing down or disrupting clinic operations.
- Conditions
- Pain Management, Injection Pain Prevention, Virtual Reality, Feasibility Studies
- Trial name
- NCT07884851
- Testing
- Immersive Virtual Reality
- Volunteers
- 45 people
- Sponsor
- Atlanta VA Medical Center
Exercise-Induced Muscle Fatigue, Fatigue Recovery
Acute Effects of High-Intensity Laser Therapy on Pain, Muscle Stiffness, and Grip Strength in Healthy Adults
The goal of this clinical trial is to learn whether high-intensity laser therapy applied before exercise reduces the loss of handgrip strength, muscle stiffness, and pain after a tiring forearm exercise in healthy adults.
- Trial name
- HILT (NCT07895862)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Acute Pain
Human Experimental Models of Pain (HEMP)
This pilot study will test an innovative way to establish how pain medicines provide analgesia in healthy adults. The study uses a group of short, controlled pain tests to look at different types of pain responses in the body.
- Trial name
- NCT07549490
- Testing
- Naproxen, Pregabalin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Healthy Volunteers
Investigating the Analgesic Potential of (2R,6R)-HNK in Acute Pain in Healthy Volunteers
Background: Opioid drugs are often prescribed for acute and chronic pain. But these drugs are addictive, and they lead to more than 14,000 overdose deaths in the United States each year.
- Trial name
- NCT07504601
- Testing
- (2R,6R)-Hydroxynorketamine
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Traumatic Rib Fracture(s), Traumatic Rib Fracture
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures
Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid…
- Trial name
- NCT07756047
- Testing
- Erector spinae plane catheter, Serratus plane catheter
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Sunnybrook Health Sciences Centre
Healthy Volunteers
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Intravenous Doses of NH302 Injection in Healthy Participants
This is a first-in-human study of NH302 injection in healthy participants. The study will test single intravenous doses of NH302 to evaluate its safety and tolerability, how the body processes NH302, and its effects on selected…
- Trial name
- NCT07892469
- Testing
- NH302 injection
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- The Third Xiangya Hospital of Central South University
Pain
An Open-Label, Safety and Efficacy Study of Cebranopadol in Participants With Acute Pain With Surgical or Non-Surgical Origin
The purpose of this study is to evaluate the safety and effectiveness of cebranopadol in treating acute pain.
- Trial name
- NCT07845071
- Testing
- Cebranopadol 400 ug
- Where
- 15 sites in United States
- Volunteers
- 160 people
- Sponsor
- Adneuris Therapeutics, Inc.
Back Pain Lower Back Chronic
Evaluation of the Short-term Effectiveness of Spinal Manipulation to Treat Acute and Subacute Low Back Pain.
Low back pain is the second most common reason for medical consultation in France and affects 60 to 80% of the working population.
- Trial name
- MeLoPe (NCT07403500)
- Testing
- Spinal or peripheral manipulation of the lower back to treat lower back pain
- Where
- France
- Volunteers
- 416 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Exercise Induced Muscle Damage, Cryotherapy
Acute Cryotherapy on Musculoskeletal Function and Biomarkers
In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more…
- Trial name
- NCT07211412
- Testing
- Cryotherapy, Eccentric exercise-induced muscle damage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas, El Paso
Completed, with results posted
All 352Pain, Pain, Postoperative
Biofeedback Based Virtual Reality Intervention to Manage Postoperative Pain
To develop and refine a technology based treatment protocol for preoperative education and training and postoperative care in children and adolescents undergoing surgery.
- Conditions
- Pain, Pain, Postoperative, Pain, Acute, Surgery
- Trial name
- NCT04943874
- Testing
- Technology Based Intervention Group 1, Technology Based Intervention Group 2
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Vanessa Olbrecht
Pain, Acute Postoperative, Renal Stone
Continuous Erector Spinae Plane Blocks to Treat Pain Following Percutaneous Nephrolithotomy
This is a randomized, triple-masked, placebo-controlled parallel-arm human subjects clinical trial investigating the addition of a continuous erector spinae plane nerve block to a single-injection erector spinae plane block to…
- Trial name
- NCT05121168
- Testing
- Active bupivacaine 0.25% via an erector spinae plane perineural catheter
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Diego
Juvenile; Scoliosis, Scoliosis Idiopathic
Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery
This is a randomized controlled trial to test effectiveness of the SurgeryPal intervention vs. education control to improve acute and chronic pain and health outcomes in youth undergoing major musculoskeletal surgery.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgeryPal (NCT04637802)
- Testing
- CBT (SurgeryPal), Education
- Where
- United States
- Volunteers
- 433 people
- Sponsor
- Seattle Children's Hospital
Opioid Use
Opioid Analgesic Reduction Study
The goal is to provide health care professionals, including dentists, with the best possible evidence for clinical decision making when deciding upon analgesics for acute post-surgical pain management, a double-blind, stratified…
- Trial name
- OARS (NCT04452344)
- Testing
- opioid-containing analgesic, two over-the-counter analgesics
- Where
- 5 sites in United States
- Volunteers
- 1,815 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Moderate to Severe Acute Lower Back Pain
Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain
This is a Phase 2, randomized, double-blind, placebo-controlled, parallel group, multicenter study to evaluate the safety and efficacy of SP-103 in subjects with moderate to severe acute lower back pain.
- Trial name
- NCT05096494
- Testing
- SP-103
- Where
- 10 sites in United States
- Volunteers
- 76 people
- Sponsor
- Scilex Pharmaceuticals, Inc.